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Volumn 141, Issue 7, 2013, Pages 887-894

Hepcidin as a central mediator of anemia of chronic diseases associated with obesity;Anemia de las enfermedades crónicas asociada a obesidad: Papel de la hepcidina como mediador central

Author keywords

Anemia; Antimicrobial cationic peptides; Chronic disease; Obesity; Refractory

Indexed keywords

HEPCIDIN;

EID: 84889636489     PISSN: 00349887     EISSN: 07176163     Source Type: Journal    
DOI: 10.4067/S0034-98872013000700008     Document Type: Review
Times cited : (10)

References (65)
  • 2
    • 77949879761 scopus 로고    scopus 로고
    • Iron in obesity. An ancient micronutrient for a modern disease
    • Zafon C, Lecube A, Simó R. Iron in obesity. An ancient micronutrient for a modern disease. Obes Rev 2010; 11: 322-8.
    • (2010) Obes Rev , vol.11 , pp. 322-328
    • Zafon, C.1    Lecube, A.2    Simó, R.3
  • 3
    • 84855167863 scopus 로고    scopus 로고
    • Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
    • Sanad M, Osman M, Gharib A. Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study. Ital J Pediatr 2011; 37: 34.
    • (2011) Ital J Pediatr , vol.37 , pp. 34
    • Sanad, M.1    Osman, M.2    Gharib, A.3
  • 4
    • 3042821673 scopus 로고
    • Hypoferraemia in obese adolescents
    • Wenzel BJ, Stults HB, Mayer J. Hypoferraemia in obese adolescents. Lancet 1962; 2: 327-8.
    • (1962) Lancet , vol.2 , pp. 327-328
    • Wenzel, B.J.1    Stults, H.B.2    Mayer, J.3
  • 5
    • 37349102255 scopus 로고    scopus 로고
    • Obesity related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption
    • Menzie CM, Yanoff LB, Denkinger BI, Mchugh T, Sebring NG, Calis KA, et al. Obesity related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. J Am Diet Assoc 2008; 108: 145-8.
    • (2008) J Am Diet Assoc , vol.108 , pp. 145-148
    • Menzie, C.M.1    Yanoff, L.B.2    Denkinger, B.I.3    McHugh, T.4    Sebring, N.G.5    Calis, K.A.6
  • 6
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003; 102: 783-8.
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 7
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun, M, Devaux I, Beaumont C, Grandchamp B, Kahn A, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci 2001; 98: 8780-5.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3    Beaumont, C.4    Grandchamp, B.5    Kahn, A.6
  • 8
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2011; 276: 7806-10.
    • (2011) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 9
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfidebonded human peptide, exhibits antimicrobial activity
    • Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, et al. LEAP-1, a novel highly disulfidebonded human peptide, exhibits antimicrobial activity. FEBS 2000; 480: 147-50.
    • (2000) FEBS , vol.480 , pp. 147-150
    • Krause, A.1    Neitz, S.2    Magert, H.J.3    Schulz, A.4    Forssmann, W.G.5    Schulz-Knappe, P.6
  • 10
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and Disorders of Iron Metabolism
    • Ganz T, Nemeth E. Hepcidin and Disorders of Iron Metabolism. Annu Rev Med 2011; 62: 347-60.
    • (2011) Annu Rev Med , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 12
    • 33748265283 scopus 로고    scopus 로고
    • Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH
    • Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 2006; 131: 788-96.
    • (2006) Gastroenterology , vol.131 , pp. 788-796
    • Bekri, S.1    Gual, P.2    Anty, R.3    Luciani, N.4    Dahman, M.5    Ramesh, B.6
  • 13
    • 2342421100 scopus 로고    scopus 로고
    • Hepcidin and its role in iron absorption
    • Robson KJ. Hepcidin and its role in iron absorption. Gut 2004; 53: 617-9.
    • (2004) Gut , vol.53 , pp. 617-619
    • Robson, K.J.1
  • 14
    • 36549034762 scopus 로고    scopus 로고
    • Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin
    • Valore E, Ganz T. Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis 2008; 40: 132-8.
    • (2008) Blood Cells Mol Dis , vol.40 , pp. 132-138
    • Valore, E.1    Ganz, T.2
  • 15
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001; 276: 7811-9.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6
  • 17
    • 73149083742 scopus 로고    scopus 로고
    • Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
    • Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology 2009; 50: 1992-2000.
    • (2009) Hepatology , vol.50 , pp. 1992-2000
    • Wallace, D.F.1    Summerville, L.2    Crampton, E.M.3    Frazer, D.M.4    Anderson, G.J.5    Subramaniam, V.N.6
  • 18
    • 60249095353 scopus 로고    scopus 로고
    • Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness
    • Truksa J, Lee P, Beutler E. Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness. Blood 2009, 113: 688-95.
    • (2009) Blood , vol.113 , pp. 688-695
    • Truksa, J.1    Lee, P.2    Beutler, E.3
  • 19
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 2006; 38: 531-9.
    • (2006) Nat Genet , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3    Xia, Y.4    Sidis, Y.5    Samad, T.A.6
  • 20
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute phase protein
    • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute phase protein. Blood 2003; 101: 2461-3.
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 24
    • 77953372800 scopus 로고    scopus 로고
    • Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias
    • Nemeth, E. Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias. Adv Hematol 2010; 2010: 750643.
    • (2010) Adv Hematol , vol.2010 , pp. 750643
    • Nemeth, E.1
  • 25
    • 77955005442 scopus 로고    scopus 로고
    • Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
    • De Domenico I, Zhang TY, Koening CL, Branch RW, London N, Lo E, et al. Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest 2010; 120: 2395-405.
    • (2010) J Clin Invest , vol.120 , pp. 2395-2405
    • De Domenico, I.1    Zhang, T.Y.2    Koening, C.L.3    Branch, R.W.4    London, N.5    Lo, E.6
  • 26
    • 33645314044 scopus 로고    scopus 로고
    • Molecular pathogenesis of anemia of chronic disease
    • Ganz T. Molecular pathogenesis of anemia of chronic disease. Pediatr Blood Cancer 2006; 46: 554-7.
    • (2006) Pediatr Blood Cancer , vol.46 , pp. 554-557
    • Ganz, T.1
  • 29
    • 53849091664 scopus 로고    scopus 로고
    • Is obesity associated with anemia of chronic disease? A population-based study
    • Ausk KJ, Ioannou GN. Is obesity associated with anemia of chronic disease? A population-based study. Obesity 2008; 16: 2356-61.
    • (2008) Obesity , vol.16 , pp. 2356-2361
    • Ausk, K.J.1    Ioannou, G.N.2
  • 31
    • 0348222671 scopus 로고    scopus 로고
    • Inflammation: The link between insulin resistance, obesity and diabetes
    • Dandona P, Aljada A, Bandyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes, Trends Immunol 2004; 25: 4-7.
    • (2004) Trends Immunol , vol.25 , pp. 4-7
    • Dandona, P.1    Aljada, A.2    Bandyopadhyay, A.3
  • 33
    • 22844437863 scopus 로고    scopus 로고
    • Endocrine and signalling role of adipose tissue: New perspectives on fat
    • Trayhurn P. Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand 2005; 184: 285-93.
    • (2005) Acta Physiol Scand , vol.184 , pp. 285-293
    • Trayhurn, P.1
  • 34
  • 36
    • 0033545342 scopus 로고    scopus 로고
    • Acute-phase proteins and other systemic responses to inflammation
    • Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340: 448-54.
    • (1999) N Engl J Med , vol.340 , pp. 448-454
    • Gabay, C.1    Kushner, I.2
  • 37
    • 0032943709 scopus 로고    scopus 로고
    • C-reactive protein in healthy subjects: Associations with obesity, insulin resistance, and endothelial dysfunction: A potential role for cytokines originating from adipose tissue?
    • Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999; 19: 972-8.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 972-978
    • Yudkin, J.S.1    Stehouwer, C.D.2    Emeis, J.J.3    Coppack, S.W.4
  • 39
    • 25644451315 scopus 로고    scopus 로고
    • Serum ferritin is associated with visceral fat area and subcutaneous fat area
    • Iwasaki T, Nakajima A, Yoneda M, Yamada Y, Mukasa K, Fujita K, et al. Serum ferritin is associated with visceral fat area and subcutaneous fat area. Diabetes Care 2005; 28: 2486-91.
    • (2005) Diabetes Care , vol.28 , pp. 2486-2491
    • Iwasaki, T.1    Nakajima, A.2    Yoneda, M.3    Yamada, Y.4    Mukasa, K.5    Fujita, K.6
  • 40
    • 37549022688 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • de Luca C, Olefsky JM. Inflammation and insulin resistance. FEBS Lett 2008; 582: 97-105.
    • (2008) FEBS Lett , vol.582 , pp. 97-105
    • de Luca, C.1    Olefsky, J.M.2
  • 41
    • 0022970902 scopus 로고
    • Insulin stimulates cellular iron uptake and causes the redistribution of intracellular transferrin receptors to the plasma membrane
    • Davis RJ, Corvera S, Czech MP. Insulin stimulates cellular iron uptake and causes the redistribution of intracellular transferrin receptors to the plasma membrane. J Biol Chem 1986; 261: 8708-11.
    • (1986) J Biol Chem , vol.261 , pp. 8708-8711
    • Davis, R.J.1    Corvera, S.2    Czech, M.P.3
  • 43
    • 0242635837 scopus 로고    scopus 로고
    • Hyperinsulinemia may boost both hematocrit and iron absorption by up-regulating activity of hypoxia-inducible factor-1α
    • McCarty MF. Hyperinsulinemia may boost both hematocrit and iron absorption by up-regulating activity of hypoxia-inducible factor-1α. Med Hypotheses 2003; 61: 567-73.
    • (2003) Med Hypotheses , vol.61 , pp. 567-573
    • McCarty, M.F.1
  • 44
    • 25144459980 scopus 로고    scopus 로고
    • IDF Epidemiology Task Force Consensus Group The metabolic syndrome-a new worldwide definition
    • Alberti KG, Zimmet P, Shaw J. IDF Epidemiology Task Force Consensus Group The metabolic syndrome-a new worldwide definition. Lancet 2005; 366: 1059-62.
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 45
    • 4644243396 scopus 로고    scopus 로고
    • Serum ferritin and risk of the metabolic syndrome in U.S. adults
    • Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care 2004; 27: 2422-8.
    • (2004) Diabetes Care , vol.27 , pp. 2422-2428
    • Jehn, M.1    Clark, J.M.2    Guallar, E.3
  • 47
    • 0029776030 scopus 로고    scopus 로고
    • The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
    • Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 1996; 93: 8374-8.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8374-8378
    • Baumann, H.1    Morella, K.K.2    White, D.W.3    Dembski, M.4    Bailon, P.S.5    Kim, H.6
  • 48
    • 35848934560 scopus 로고    scopus 로고
    • Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells
    • Chung B, Matak P, McKie AT, Sharp P. Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J Nutr 2007; 137: 2366-70.
    • (2007) J Nutr , vol.137 , pp. 2366-2370
    • Chung, B.1    Matak, P.2    McKie, A.T.3    Sharp, P.4
  • 51
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Lung Cell Mol Physiol 2007; 293: E1118-E1128.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 52
    • 14744278436 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352: 1011-23.
    • (2005) N Engl J Med , vol.352 , pp. 1011-1023
    • Weiss, G.1    Goodnough, L.T.2
  • 53
    • 77953438962 scopus 로고    scopus 로고
    • Unexplained aspects of anemia of inflammation
    • Price EA, Schrier SL. Unexplained aspects of anemia of inflammation. Adv Hematol 2010; 2010: 508739.
    • (2010) Adv Hematol , vol.2010 , pp. 508739
    • Price, E.A.1    Schrier, S.L.2
  • 54
    • 55549127206 scopus 로고    scopus 로고
    • Serum transferrin receptor
    • Skikne BS. Serum transferrin receptor. Am J Hematol 2008; 83: 872-5.
    • (2008) Am J Hematol , vol.83 , pp. 872-875
    • Skikne, B.S.1
  • 55
    • 67149084949 scopus 로고    scopus 로고
    • Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: Diagnostic and therapeutic implications
    • Theurl I, Aigner E, Theurl M, Nairz M, Seifert M, Schroll A, et al. Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood 2009; 113: 5277-8.
    • (2009) Blood , vol.113 , pp. 5277-5278
    • Theurl, I.1    Aigner, E.2    Theurl, M.3    Nairz, M.4    Seifert, M.5    Schroll, A.6
  • 56
    • 80955180940 scopus 로고    scopus 로고
    • Diagnosis and management of anaemia of chronic disease: Current status
    • Cullis JO. Diagnosis and management of anaemia of chronic disease: current status. Br J Haematol 2011; 154: 289-300.
    • (2011) Br J Haematol , vol.154 , pp. 289-300
    • Cullis, J.O.1
  • 57
    • 14544274508 scopus 로고    scopus 로고
    • Diagnosis and management of iron-deficiency anaemia
    • Cook JD. Diagnosis and management of iron-deficiency anaemia. Best Pract Res Clin Haematol 2008; 18: 319-32.
    • (2008) Best Pract Res Clin Haematol , vol.18 , pp. 319-332
    • Cook, J.D.1
  • 58
    • 46649105890 scopus 로고    scopus 로고
    • Methods to assess iron and iodine status
    • Zimmermann MB. Methods to assess iron and iodine status. Br J Nutr 2008; 99: S2-S9.
    • (2008) Br J Nutr , vol.99
    • Zimmermann, M.B.1
  • 59
    • 43049132128 scopus 로고    scopus 로고
    • A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells
    • Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU. A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med 2008; 86: 531-40.
    • (2008) J Mol Med , vol.86 , pp. 531-540
    • Verga Falzacappa, M.V.1    Casanovas, G.2    Hentze, M.W.3    Muckenthaler, M.U.4
  • 61
    • 33645295541 scopus 로고    scopus 로고
    • Hepcidin: An important new regulator of iron homeostasis
    • Hugman A. Hepcidin: an important new regulator of iron homeostasis. Clin Lab Haematol 2006; 28: 75-83.
    • (2006) Clin Lab Haematol , vol.28 , pp. 75-83
    • Hugman, A.1
  • 62
    • 84859417866 scopus 로고    scopus 로고
    • The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders
    • Ganz T, Nemeth E. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology Am Soc Hematol Educ Program 2011; 2011: 538-42.
    • (2011) Hematology Am Soc Hematol Educ Program , vol.2011 , pp. 538-542
    • Ganz, T.1    Nemeth, E.2
  • 63
    • 67349115201 scopus 로고    scopus 로고
    • Iron metabolism in the anemia of chronic disease
    • Weiss, G. Iron metabolism in the anemia of chronic disease. Biochim Biophys Acta 2009; 1790: 682-93.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 682-693
    • Weiss, G.1
  • 64
    • 34247366783 scopus 로고    scopus 로고
    • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation
    • Roy CN, Mak HH, Akpan I, Losyev G, Zurakowski D, Andrews NC. Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation Blood 2007; 109: 4038-44.
    • (2007) Blood , vol.109 , pp. 4038-4044
    • Roy, C.N.1    Mak, H.H.2    Akpan, I.3    Losyev, G.4    Zurakowski, D.5    Andrews, N.C.6
  • 65
    • 84862792124 scopus 로고    scopus 로고
    • Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation
    • Sun CC, Vaja V, Babitt JL, Lin HY. Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation. Am J Hematol 2012; 87: 392-400.
    • (2012) Am J Hematol , vol.87 , pp. 392-400
    • Sun, C.C.1    Vaja, V.2    Babitt, J.L.3    Lin, H.Y.4


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