Thrombocytopenia in septic shock patients - A prospective observational study of incidence, risk factors and correlation with clinical outcome

Anaesthesia and Intensive Care

Volumn 35, Issue 6, 2007, Pages 874-880

  Sharma, B ^a   Sharma, M ^a   Majumder, M ^a   Steier, W ^a,b   Sangal, A ^a   Kalawar, M ^a  

^a BROOKDALE UNIVERSITY HOSPITAL AND MEDICAL CENTER   (United States)

^b Hematology and Oncology Fellowship Program

Author keywords

Critically ill; Mortality; Platelet count; Prognosis; Sepsis; Septic shock; Thrombocytopenia

Indexed keywords

CREATININE; HYPERTENSIVE AGENT;

ADULT; AGED; ARTICLE; BLOOD CELL COUNT; CONTROLLED STUDY; CORRELATIONAL STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HUMAN; INCIDENCE; INTENSIVE CARE PSYCHOSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SCORING SYSTEM; SEPTIC SHOCK; THROMBOCYTOPENIA;

EID: 37049009297     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x0703500604     Document Type: Article

References (22)

1. Stephan F, Hollande J, Richard O, Heffi A, Maier-Redelsperger M, Flahault A. Thrombocytopenia in a surgical ICU. Chest 1999; 115:1363-1370.
2. Corrigan JJ Jr, Ray WL, May N. Changes in the blood coagulation system associated with septicemia. N Engl J Med 1968; 279:851-856.
3. Neame PB, Kelton JG, Walker IR, Stewart IO, Nossel HL, Hirsh J. Thrombocytopenia in septicemia: the role of disseminated intravascular coagulation. Blood 1980; 56:88-92.
4. Stephan F, Thioliere B, Verdy E, Tulliez M. Role of hemophagocytic histiocytosis in the etiology of thrombocytopenia in patients with sepsis syndrome or septic shock. Clin Infect Dis 1997; 25:1159-1164.
5. Francois B, Trimoreau F, Vignon P, Fixe P, Praloran V, Gastinne H. Thrombocytopenia in the sepsis syndrome: role of hemophagocytosis and macrophage colony-stimulating factor. Am J Med 1997; 103:114-120.
6. Poskitt TR, Poskitt PK. Thrombocytopenia of sepsis. The role of circulating IgG-containing immune complexes. Arch Intern Med 1985; 145:891-894.
7. Baughman RP, Lower EE, Flessa HC, Tollerud DJ. Thrombocytopenia in the intensive care unit. Chest 1993; 104:1243-1247.
8. Kim YL, Richman KA, Marshall BE. Thrombocytopenia associated with Swan-Ganz catheterization in patients. Anesthesiology 1980; 53:261-262.
9. Strauss R, Wehler M, Mehler K, Kreutzer D, Koebnick C, Hahn EG. Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome. Crit Care Med 2002; 30:1765-1771.
10. Vanderschueren S, De Weerdt A, Malbrain M, Vankersschaever D, Frans E, Wilmer A et al. Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000; 28:1871-1876.
11. Sprung CL, Peduzzi PN, Shatney CH, Schein RM, Wilson MF, Sheagren JN et al. Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. Crit Care Med 1990; 18:801-806.
12. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874.
13. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985; 13:818-829.
14. Le Gall JR, Klar J, Lemeshow S, Saulnier F, Alberti C, Artigas A et al. Logistic Organ Dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group. JAMA 1996; 276:802-810.
15. Vincent JL, de Mendonca A, Cantraine F, Moreno R, Takala J, Suter PM et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med 1998; 26:1793-1800.
16. Bonfiglio MF, Traeger SM, Kier KL, Martin BR, Hulisz DT, Verbeck SR. Thrombocytopenia in intensive care patients: a comprehensive analysis of risk factors in 314 patients. Ann Pharmacother 1995; 29:835-842.
17. Hanes SD, Quarles DA, Boucher BA. Incidence and risk factors of thrombocytopenia in critically ill trauma patients. Ann Pharmacother 1997; 31:285-289.
18. Riedler GF, Straub PW, Frick PG. Thrombocytopenia in septicemia. A clinical study for the evaluation of its incidence and diagnostic value. Helv Med Acta 1971; 36:23-28.
19. Brun-Buisson C, Doyon F, Carlet J, Dellamonica P, Gouin F, Lepoutre A et al. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. JAMA 1995; 274:968-974.
20. Shalansky SJ, Verma AK, Levine M, Spinelli JJ, Dodek PM. Risk markers for thrombocytopenia in critically ill patients: a prospective analysis. Pharmacotherapy 2002; 22:803-813.
21. Drews RE. Critical issues in hematology: anemia, thrombocytopenia, coagulopathy, and blood product transfusions in critically ill patients. Clin Chest Med 2003; 24:607-622.
22. Kitchens CS. Disseminated intravascular coagulation. Curr Opin Hematol 1995; 2:402-406.