A prostaglandin E2 receptor subtype EP4 agonist attenuates cardiovascular depression in endotoxin shock by inhibiting inflammatory cytokines and nitric oxide production

Shock

Volumn 22, Issue 1, 2004, Pages 76-81

  Sakamoto, Atsuhiro ^a   Matsumura, Junya ^a   Mii, Seiji ^a   Gotoh, Yoshitugu ^a   Ogawa, Ryo ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Interleukin; Lipopolysaccharide; Nitrosyl hemoglobin; Reverse transcription polymerase chain reaction; Tumor necrosis factor

Indexed keywords

CYTOKINE; HEMOGLOBIN DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITROSYLHEMOGLOBIN; NORADRENALIN; ONO AE1 329; PENTOBARBITAL; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR AFFECTING AGENT; RECEPTOR SUBTYPE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; EP4 RECEPTOR; ETHER DERIVATIVE; ONO-AE1-329;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD LEVEL; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR DEPRESSION; CARDIOVASCULAR FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESCENDING AORTA; DOSE RESPONSE; ELECTRON SPIN RESONANCE; GENE EXPRESSION; HEART LEFT VENTRICLE; HEMODYNAMICS; HYPOTENSION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MALE; MEAN ARTERIAL PRESSURE; NEUTROPHIL; NONHUMAN; PRESSOR RESPONSE; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPTIC SHOCK; ANIMAL; BLOOD; CARDIOVASCULAR SYSTEM; CHO CELL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; HAMSTER; IMMUNOLOGY; METABOLISM; MOUSE; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CARDIOVASCULAR SYSTEM; CHO CELLS; CRICETINAE; CYTOKINES; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; METHYL ETHERS; MICE; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E; SHOCK, SEPTIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 11444252313     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000129338.99410.5d     Document Type: Article

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