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Volumn , Issue , 2008, Pages 1-16

Exploring the Potential of Natural Products in Cancer Treatment

Author keywords

Anticancer drugs teniposide and etoposide; Bioactive natural products search; Combinatorial biosynthesis modifying biosynthetic pathways; Marine organisms and nuclear factor (NF) B inhibitors; Medicinal chemists and 'drug like' features; Natural product potential novel anticancer drugs; Natural products in cancer treatment; Podophyllum peltatum linnaeus and podophyllum emodii; Traditional holistic medicinal systems

Indexed keywords


EID: 84889317963     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470697047.ch1     Document Type: Chapter
Times cited : (5)

References (46)
  • 1
    • 27844474247 scopus 로고    scopus 로고
    • Drug discovery from medicinal plants
    • Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci 2005, 78(5), 431-41.
    • (2005) Life Sci , vol.78 , Issue.5 , pp. 431-441
    • Balunas, M.J.1    Kinghorn, A.D.2
  • 3
    • 19644393308 scopus 로고    scopus 로고
    • Bioactive microbial metabolites: a personal view
    • Berdy J. Bioactive microbial metabolites: a personal view. J Antibiot 2005, 58, 1-26.
    • (2005) J Antibiot , vol.58 , pp. 1-26
    • Berdy, J.1
  • 4
    • 2942590399 scopus 로고    scopus 로고
    • Libraries from natural product-like scaffolds
    • Boldi AM. Libraries from natural product-like scaffolds. Curr Opin Chem Biol 2004, 8, 281-286.
    • (2004) Curr Opin Chem Biol , vol.8 , pp. 281-286
    • Boldi, A.M.1
  • 5
    • 33745801367 scopus 로고    scopus 로고
    • Cluster analysis as selection and dereplication tool for the identification of new natural compounds from large sample sets
    • Böröczky K, Laatsch H, Wagner-Döbler I, Stritzke K, Schulz S. Cluster analysis as selection and dereplication tool for the identification of new natural compounds from large sample sets. Chem Biodivers 2006, 3(6), 622-34.
    • (2006) Chem Biodivers , vol.3 , Issue.6 , pp. 622-634
    • Böröczky, K.1    Laatsch, H.2    Wagner-Döbler, I.3    Stritzke, K.4    Schulz, S.5
  • 6
    • 0001311261 scopus 로고    scopus 로고
    • Anticancer drug development: the way forward
    • Connors T. Anticancer drug development: the way forward. Oncologist 1996, 1(3), 180-81.
    • (1996) Oncologist , vol.1 , Issue.3 , pp. 180-181
    • Connors, T.1
  • 7
    • 0036048066 scopus 로고    scopus 로고
    • Poisoning the spindle: serendipity and discovery of the anti-tumour properties of the Vinca alkaloids
    • Duffin J. Poisoning the spindle: serendipity and discovery of the anti-tumour properties of the Vinca alkaloids. Pharm Hist 2002, 44(2), 64-76.
    • (2002) Pharm Hist , vol.44 , Issue.2 , pp. 64-76
    • Duffin, J.1
  • 8
    • 33644878571 scopus 로고    scopus 로고
    • SuperNatural: a searchable database of available natural compounds
    • Database issue
    • Dunkel M, Fullbeck M, Neumann S, Preissner R. SuperNatural: a searchable database of available natural compounds. Nucleic Acids Res 2006, 34(Database issue): D678-83.
    • (2006) Nucleic Acids Res , vol.34
    • Dunkel, M.1    Fullbeck, M.2    Neumann, S.3    Preissner, R.4
  • 9
    • 33847638137 scopus 로고    scopus 로고
    • Estimates of the cancer incidence and mortality in Europe in 2006
    • Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007, 18(3), 581-92.
    • (2007) Ann Oncol , vol.18 , Issue.3 , pp. 581-592
    • Ferlay, J.1    Autier, P.2    Boniol, M.3    Heanue, M.4    Colombet, M.5    Boyle, P.6
  • 10
    • 33744537000 scopus 로고    scopus 로고
    • Combinatorial biosynthesis-Potential and problems
    • Floss HG. Combinatorial biosynthesis-Potential and problems. J Biotech 2006, 124, 242-57.
    • (2006) J Biotech , vol.124 , pp. 242-257
    • Floss, H.G.1
  • 11
    • 37849022679 scopus 로고    scopus 로고
    • Marine natural products as targeted modulators of the transcription factor NF-kappaB
    • Folmer F, Jaspars M, Dicato M, Diederich M. Marine natural products as targeted modulators of the transcription factor NF-kappaB. Biochem Pharmacol 2008, 75(3), 603-17.
    • (2008) Biochem Pharmacol , vol.75 , Issue.3 , pp. 603-617
    • Folmer, F.1    Jaspars, M.2    Dicato, M.3    Diederich, M.4
  • 12
    • 17444362637 scopus 로고    scopus 로고
    • An MS/MS library on an ion-trap instrument for efficient dereplication of natural products. Different fragmentation patterns for [M + H]C and [M + Na]C ions
    • Fredenhagen A, Derrien C, Gassmann E. An MS/MS library on an ion-trap instrument for efficient dereplication of natural products. Different fragmentation patterns for [M + H]C and [M + Na]C ions. J Nat Prod 2005, 68(3), 385-91.
    • (2005) J Nat Prod , vol.68 , Issue.3 , pp. 385-391
    • Fredenhagen, A.1    Derrien, C.2    Gassmann, E.3
  • 13
  • 14
    • 0033697116 scopus 로고    scopus 로고
    • Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives
    • Graham JG, Quinn ML, Fabricant DS, Farnsworth NR. Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives. J Ethnopharmacol 2000, 73(3), 347-77.
    • (2000) J Ethnopharmacol , vol.73 , Issue.3 , pp. 347-377
    • Graham, J.G.1    Quinn, M.L.2    Fabricant, D.S.3    Farnsworth, N.R.4
  • 15
    • 35348824837 scopus 로고    scopus 로고
    • Natural products as a screening source
    • Harvey AL. Natural products as a screening source. Curr Opin Chem Biol 2007, 11, 480-484.
    • (2007) Curr Opin Chem Biol , vol.11 , pp. 480-484
    • Harvey, A.L.1
  • 16
    • 33947183424 scopus 로고    scopus 로고
    • Uses and abuses of in vitso tests in ethnopharmacology: visualizing an elephant
    • Houghton PJ, Howes M-J, Lee CC, Steventon G. Uses and abuses of in vitso tests in ethnopharmacology: visualizing an elephant. J Ethnopharmacol 2007, 110, 391-400.
    • (2007) J Ethnopharmacol , vol.110 , pp. 391-400
    • Houghton, P.J.1    Howes, M.-J.2    Lee, C.C.3    Steventon, G.4
  • 17
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinber R. The hallmarks of cancer. Cell 2000, 100(1), 57-70.
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinber, R.2
  • 18
    • 0015081705 scopus 로고
    • Plants used against cancer
    • Hartwell JL. Plants used against cancer. A survey. Lloydia 1971, 34(2), 204-55.
    • (1971) A survey. Lloydia , vol.34 , Issue.2 , pp. 204-255
    • Hartwell, J.L.1
  • 19
    • 0034882210 scopus 로고    scopus 로고
    • Twenty-five years of chemical ecology
    • Harborne JB. Twenty-five years of chemical ecology. Nat Prod Rep 2001, 18(4), 361-79.
    • (2001) Nat Prod Rep , vol.18 , Issue.4 , pp. 361-379
    • Harborne, J.B.1
  • 20
    • 1442285598 scopus 로고    scopus 로고
    • Personal recollections on the early development of taxol
    • Horwitz SB. Personal recollections on the early development of taxol. J Nat Prod 2004, 67(2), 136-8.
    • (2004) J Nat Prod , vol.67 , Issue.2 , pp. 136-138
    • Horwitz, S.B.1
  • 21
    • 0028163714 scopus 로고
    • Strategies for the discovery of secondary metabolites from marine bacteria: ecological perspectives
    • Jensen PR, Fenical W. Strategies for the discovery of secondary metabolites from marine bacteria: ecological perspectives. Annu Rev Microbiol 1994, 48, 559-84.
    • (1994) Annu Rev Microbiol , vol.48 , pp. 559-584
    • Jensen, P.R.1    Fenical, W.2
  • 22
    • 33751245592 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of medicinal plant secondary metabolites
    • Julsing MK, Koulman A, Woerdenbag HJ, Quax WJ, Kayser O. Combinatorial biosynthesis of medicinal plant secondary metabolites. Biomol Eng 2006, 23(6), 265-79.
    • (2006) Biomol Eng , vol.23 , Issue.6 , pp. 265-279
    • Julsing, M.K.1    Koulman, A.2    Woerdenbag, H.J.3    Quax, W.J.4    Kayser, O.5
  • 23
    • 33947714587 scopus 로고    scopus 로고
    • SERMs: meeting the promise of multifunctional medicines
    • Jordan VC. SERMs: meeting the promise of multifunctional medicines. J Natl Cancer Inst 2007, 99(5), 350-6.
    • (2007) J Natl Cancer Inst , vol.99 , Issue.5 , pp. 350-356
    • Jordan, V.C.1
  • 24
    • 33947306802 scopus 로고    scopus 로고
    • Taxoids: cancer-fighting compounds from nature
    • Kingston DG, Newman DJ. Taxoids: cancer-fighting compounds from nature. Curr Opin Drug Discov Devel 2007, 10(2), 130-44.
    • (2007) Curr Opin Drug Discov Devel , vol.10 , Issue.2 , pp. 130-144
    • Kingston, D.G.1    Newman, D.J.2
  • 25
    • 36549043394 scopus 로고    scopus 로고
    • NAPROC-13: a database for the dereplication of natural product mixtures in bioassay-guided protocols
    • López-Pérez JL, Therón R, del Olmo E, Díaz D. NAPROC-13: a database for the dereplication of natural product mixtures in bioassay-guided protocols. Bioinformatics 2007, 23(23), 3256-7.
    • (2007) Bioinformatics , vol.23 , Issue.23 , pp. 3256-3257
    • López-Pérez, J.L.1    Therón, R.2    Del Olmo, E.3    Díaz, D.4
  • 26
    • 0033920537 scopus 로고    scopus 로고
    • Anti-cancer drug discovery and development in Brazil: targeted plant collection as a rational strategy to acquire candidate anti-cancer compounds
    • Mans DR, da Rocha AB, Schwartsmann G. Anti-cancer drug discovery and development in Brazil: targeted plant collection as a rational strategy to acquire candidate anti-cancer compounds. Oncologist 2000, 5(3), 185-98.
    • (2000) Oncologist , vol.5 , Issue.3 , pp. 185-198
    • Mans, D.R.1    Da Rocha, A.B.2    Schwartsmann, G.3
  • 27
    • 84889276803 scopus 로고    scopus 로고
    • Accessing the genomes of uncultivated microbes for novel natural products
    • In: Natural Products: Drug Discovery and Therapeutic Medicine, edited by L Zhang and AL Demain. Humana Press Inc., Totowa, NJ
    • Martinez A, Hopke J, MacNeil IA, Osburne MS. Accessing the genomes of uncultivated microbes for novel natural products. In: Natural Products: Drug Discovery and Therapeutic Medicine, edited by L Zhang and AL Demain. Humana Press Inc., Totowa, NJ, 2000.
    • (2000)
    • Martinez, A.1    Hopke, J.2    MacNeil, I.A.3    Osburne, M.S.4
  • 28
    • 34447096207 scopus 로고    scopus 로고
    • Plant natural products: back to the future or into extinction?
    • McChesney JD, Venkataramans SK, Henri JT. Plant natural products: back to the future or into extinction? Phytochemistry 2007, 68, 2015-22.
    • (2007) Phytochemistry , vol.68 , pp. 2015-2022
    • McChesney, J.D.1    Venkataramans, S.K.2    Henri, J.T.3
  • 30
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007, 70(3), 461-77.
    • (2007) J Nat Prod , vol.70 , Issue.3 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 31
    • 0028012837 scopus 로고
    • Total synthesis of taxol
    • Nicolaou KC, Yang Z, Liu JJ, et al. Total synthesis of taxol. Nature 1994, 367(6464), 630-4.
    • (1994) Nature , vol.367 , Issue.6464 , pp. 630-634
    • Nicolaou, K.C.1    Yang, Z.2    Liu, J.J.3
  • 32
    • 0032788030 scopus 로고    scopus 로고
    • Origins of immunity: transcription factors and homologues of effector genes of the vertebrate immune system expressed in sea urchin coelomocytes
    • Pancer Z, Rast JP, Davidson EH. Origins of immunity: transcription factors and homologues of effector genes of the vertebrate immune system expressed in sea urchin coelomocytes. Immunogenetics 1999, 49, 773-86.
    • (1999) Immunogenetics , vol.49 , pp. 773-786
    • Pancer, Z.1    Rast, J.P.2    Davidson, E.H.3
  • 33
    • 3042726987 scopus 로고    scopus 로고
    • Soil DNA libraries for anticancer drug discovery
    • Pettit RK. Soil DNA libraries for anticancer drug discovery. Cancer Chemother Pharmacol 2004, 54, 1-6
    • (2004) Cancer Chemother Pharmacol , vol.54 , pp. 1-6
    • Pettit, R.K.1
  • 34
    • 23044471389 scopus 로고    scopus 로고
    • Bioguided isolation of pharmacologically active plant components, still a valuable strategy for the finding of new lead compounds?
    • Pieters LA, Vlietinck AJ. Bioguided isolation of pharmacologically active plant components, still a valuable strategy for the finding of new lead compounds? J Ethnopharmacol 2005, 100, 57-60
    • (2005) J Ethnopharmacol , vol.100 , pp. 57-60
    • Pieters, L.A.1    Vlietinck, A.J.2
  • 35
    • 33644826997 scopus 로고    scopus 로고
    • A role for physicians in ethnopharmacology and drug discovery
    • Raza M. A role for physicians in ethnopharmacology and drug discovery. J Ethnopharm 2006, 104, 297-301
    • (2006) J Ethnopharm , vol.104 , pp. 297-301
    • Raza, M.1
  • 36
    • 0037864005 scopus 로고    scopus 로고
    • Natural products for cancer prevention: a global perspective
    • Reddy L, Odhav B, Bhoola KD. Natural products for cancer prevention: a global perspective. Pharmacol Ther 2003, 99(1), 1-13.
    • (2003) Pharmacol Ther , vol.99 , Issue.1 , pp. 1-13
    • Reddy, L.1    Odhav, B.2    Bhoola, K.D.3
  • 37
    • 34447283477 scopus 로고    scopus 로고
    • Ins and outs of dietary phytochemicals in cancer chemoprevention
    • Russo GL. Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem Pharmacol 2007, 74(4), 533-44.
    • (2007) Biochem Pharmacol , vol.74 , Issue.4 , pp. 533-544
    • Russo, G.L.1
  • 38
    • 30344465730 scopus 로고    scopus 로고
    • New natural taxane diterpenoids from Taxus species since 1999
    • Shi QW, Kiyota H. New natural taxane diterpenoids from Taxus species since 1999. Chem Biodivers 2005, 2(12), 1597-623.
    • (2005) Chem Biodivers , vol.2 , Issue.12 , pp. 1597-1623
    • Shi, Q.W.1    Kiyota, H.2
  • 40
    • 19144361907 scopus 로고    scopus 로고
    • Camptothecin and its analogues: a review on their chemotherapeutic potential
    • Sriram D, Yogeeswari P, Thirumurugan R, Bal TR. Camptothecin and its analogues: a review on their chemotherapeutic potential. Nat Prod Res 2005, 19(4), 393-412.
    • (2005) Nat Prod Res , vol.19 , Issue.4 , pp. 393-412
    • Sriram, D.1    Yogeeswari, P.2    Thirumurugan, R.3    Bal, T.R.4
  • 41
    • 25844502482 scopus 로고    scopus 로고
    • Plant-based anticancer molecules: a chemical and biological profile of some important leads
    • Srivastava V, Negi AS, Kumar JK, Gupta MM, Khanuja SP. Plant-based anticancer molecules: a chemical and biological profile of some important leads. Bioorg Med Chem 2005, 13(21), 5892-908.
    • (2005) Bioorg Med Chem , vol.13 , Issue.21 , pp. 5892-5908
    • Srivastava, V.1    Negi, A.S.2    Kumar, J.K.3    Gupta, M.M.4    Khanuja, S.P.5
  • 43
    • 1942453222 scopus 로고    scopus 로고
    • Unconventional natural sources for future drug discovery
    • Tulp M, Bohlin L. Unconventional natural sources for future drug discovery. Drug Discov Today 2004, 9(10), 450-8.
    • (2004) Drug Discov Today , vol.9 , Issue.10 , pp. 450-458
    • Tulp, M.1    Bohlin, L.2
  • 44
    • 34347212125 scopus 로고    scopus 로고
    • Trabectedin-a targeted chemotherapy?
    • von Mehren M. Trabectedin-a targeted chemotherapy? Lancet Oncol 2007, 8(7), 565-7.
    • (2007) Lancet Oncol , vol.8 , Issue.7 , pp. 565-567
    • von Mehren, M.1
  • 45
    • 0028896166 scopus 로고
    • Camptothecin and taxol: discovery to clinic-thirteenth Bruce F. Cain Memorial Award Lecture
    • Wall ME, Wani MC. Camptothecin and taxol: discovery to clinic-thirteenth Bruce F. Cain Memorial Award Lecture. Cancer Res 1995, 55(4), 753-60.
    • (1995) Cancer Res , vol.55 , Issue.4 , pp. 753-760
    • Wall, M.E.1    Wani, M.C.2
  • 46
    • 0037318402 scopus 로고    scopus 로고
    • A genomics-guided approach for discovering and expressing cryptic metabolic pathways
    • Zazopoulos E, Huang K, Staffa A, et al. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat Biotechnol 2003, 21(2), 187-90.
    • (2003) Nat Biotechnol , vol.21 , Issue.2 , pp. 187-190
    • Zazopoulos, E.1    Huang, K.2    Staffa, A.3


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