Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship

Journal of Medicinal Chemistry

Volumn 56, Issue 22, 2013, Pages 9071-9088

  Christensen, Mette K ^a,g   Erichsen, Kamille D ^a,k   Olesen, Uffe H ^a,c   Tjørnelund, Jette ^a   Fristrup, Peter ^e   Thougaard, Annemette ^a,h   Nielsen, Søren Jensby ^a,i   Sehested, Maxwell ^a,c   Jensen, Peter B ^a,j   Loza, Einars ^f   Kalvinsh, Ivars ^f   Garten, Antje ^d   Kiess, Wieland ^d   Björkling, Fredrik ^a,b  

^a BioAlliance Pharma   (France)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c University of Copenhagen   (Denmark)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^f LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^g NOVO NORDISK A S   (Denmark)

^h H LUNDBECK A S   (Denmark)

ⁱ Nuevolotion A S   (Denmark)

^j Medical Prognosis Institute   (Denmark)

^k BioAdvice Aps   (Denmark)

more..

Author keywords

[No Author keywords available]

Indexed keywords

4 {2 [(CYCLOHEXYLAMINO)OXY]ETHYL}MORPHOLINE; 6 (1,3 DIOXO 1,3 DIHYDRO 2H ISOINDOL 2 YL) 1 HEXANESULFONATE; 6 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) HEXANESULFONYL CHLORIDE; 6 [2 CYANO 3 (PYRIDIN 4 YL)GUANIDINO] N CYCLOHEXYL N(2 MORPHOLINOETHOXY)HEXANE 1 SULFONAMIDE; 6 AMINO N CYCLOHEXYL N (2 MORPHOLINOETHOXY) 1 HEXANESULFONAMIDE; ANTINEOPLASTIC AGENT; CYANOGUANIDINE INHIBITOR; CYCLOHEXANONE O (2 MORPHOLIN 4 YLETHYL)OXIME; DAPORINAD; GUANIDINE DERIVATIVE; N CYCLOHEXYL 6 (1,3 DIOXO 1,3 DIHYDRO 2H ISOINDOL 2 YL) N (2 MORPHOLINOETHOXY) 1 HEXANESULFONAMIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; O (2 MORPHOLINOETHYL)HYDROXYLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY CARCINOMA; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; ENZYME INHIBITORS; GUANIDINES; HUMANS; HYDROGEN BONDING; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR DOCKING SIMULATION; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84889261827     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4009949     Document Type: Article

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