Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-cyanoguanidine bioisosteres possessing in vive bladder selectivity

Journal of Medicinal Chemistry

Volumn 43, Issue 6, 2000, Pages 1187-1202

  Butera, John A ^a   Antane, Madelene M ^a   Antane, Schuyler A ^a   Argentieri, Thomas M ^a   Freeden, Chris ^a   Graceffa, Russell F ^a   Hirth, Bradford H ^a   Jenkins, Douglas ^a   Lennox, Joseph R ^a   Matelan, Edward ^a   Norton, N Wesley ^a   Quagliato, Dominick ^a   Sheldon, Jeffrey H ^a   Spinelli, Walter ^a   Warga, Dawn ^a   Wojdan, Alexandra ^a   Woods, Morgan ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [3,4 DIOXO 2 (1,2,2 TRIMETHYLPROPYYLAMINO)CYCLOBUT 1 ENYLAMINO] 3 ETHYL BENZONITRILE; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; CHANNEL GATING; DRUG ACTIVITY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; FEMALE; HYPERPOLARIZATION; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; URGE INCONTINENCE; URINE INCONTINENCE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD PRESSURE; CYCLOBUTANES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FEMALE; HEART RATE; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITRILES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; URINARY BLADDER; URINARY INCONTINENCE;

EID: 17144465234     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9905099     Document Type: Article

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