-
1
-
-
33847711060
-
The power to reduce: pyridine nucleotides-small molecules with a multitude of functions
-
Pollak N, Dolle C, Ziegler M. The power to reduce: pyridine nucleotides-small molecules with a multitude of functions. Biochem J 2007;402:205-18.
-
(2007)
Biochem J
, vol.402
, pp. 205-218
-
-
Pollak, N.1
Dolle, C.2
Ziegler, M.3
-
2
-
-
50349083286
-
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
-
Malavasi F, Deaglio S, Funaro A, Ferrero E, Horenstein AL, Ortolan E, et al. Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. Physiol Rev 2008;88:841-86.
-
(2008)
Physiol Rev
, vol.88
, pp. 841-886
-
-
Malavasi, F.1
Deaglio, S.2
Funaro, A.3
Ferrero, E.4
Horenstein, A.L.5
Ortolan, E.6
-
3
-
-
62649156291
-
Nampt: linking NAD biology, metabolism and cancer
-
Garten A, Petzold S, Korner A, Imai S, Kiess W. Nampt: linking NAD biology, metabolism and cancer. Trends Endocrinol Metab 2009;20:130-8.
-
(2009)
Trends Endocrinol Metab
, vol.20
, pp. 130-138
-
-
Garten, A.1
Petzold, S.2
Korner, A.3
Imai, S.4
Kiess, W.5
-
4
-
-
62149148872
-
Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases
-
Imai S. Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Curr Pharm Des 2009;15:20-8.
-
(2009)
Curr Pharm Des
, vol.15
, pp. 20-28
-
-
Imai, S.1
-
5
-
-
58149316660
-
Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress
-
Rongvaux A, Galli M, Denanglaire S, Van Gool F, Dreze PL, Szpirer C, et al. Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress. J Immunol 2008;181:4685-95.
-
(2008)
J Immunol
, vol.181
, pp. 4685-4695
-
-
Rongvaux, A.1
Galli, M.2
Denanglaire, S.3
Van Gool, F.4
Dreze, P.L.5
Szpirer, C.6
-
6
-
-
34548627517
-
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
-
Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, et al. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 2007;130:1095-107.
-
(2007)
Cell
, vol.130
, pp. 1095-1107
-
-
Yang, H.1
Yang, T.2
Baur, J.A.3
Perez, E.4
Matsui, T.5
Carmona, J.J.6
-
7
-
-
0242526050
-
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis
-
Hasmann M, Schemainda I. FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res 2003;63:7436-42.
-
(2003)
Cancer Res
, vol.63
, pp. 7436-7442
-
-
Hasmann, M.1
Schemainda, I.2
-
8
-
-
0035218022
-
Activity of CHS 828 in primary cultures of human hematological and solid tumors in vitro
-
Aleskog A, Bashir-Hassan S, Hovstadius P, Kristensen J, Hoglund M, Tholander B, et al. Activity of CHS 828 in primary cultures of human hematological and solid tumors in vitro. Anticancer Drugs 2001;12:821-7.
-
(2001)
Anticancer Drugs
, vol.12
, pp. 821-827
-
-
Aleskog, A.1
Bashir-Hassan, S.2
Hovstadius, P.3
Kristensen, J.4
Hoglund, M.5
Tholander, B.6
-
9
-
-
65149084441
-
The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies
-
Nahimana A, Attinger A, Aubry D, Greaney P, Ireson C, Thougaard AV, et al. The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies. Blood 2009;113:3276-86.
-
(2009)
Blood
, vol.113
, pp. 3276-3286
-
-
Nahimana, A.1
Attinger, A.2
Aubry, D.3
Greaney, P.4
Ireson, C.5
Thougaard, A.V.6
-
10
-
-
38649096263
-
Anticancer agent CHS-828 inhibits cellular synthesis of NAD
-
Olesen UH, Christensen MK, Bjorkling F, Jaattela M, Jensen PB, Sehested M, et al. Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun 2008;367:799-804.
-
(2008)
Biochem Biophys Res Commun
, vol.367
, pp. 799-804
-
-
Olesen, U.H.1
Christensen, M.K.2
Bjorkling, F.3
Jaattela, M.4
Jensen, P.B.5
Sehested, M.6
-
11
-
-
70350538957
-
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in NAPRT1-deficient tumors
-
Watson M, Roulston A, Belec L, Billot X, Marcellus R, Bedard D, et al. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in NAPRT1-deficient tumors. Mol Cell Biol 2009;29:5872-88.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5872-5888
-
-
Watson, M.1
Roulston, A.2
Belec, L.3
Billot, X.4
Marcellus, R.5
Bedard, D.6
-
12
-
-
77953408297
-
A preclinical study on the rescue of normal tissue by nicotinic acid in high dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor
-
Olesen UH, Thougaard AV, Jensen PB, Sehested M. A preclinical study on the rescue of normal tissue by nicotinic acid in high dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor. Mol Cancer Ther 2010;9:1609-17.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1609-1617
-
-
Olesen, U.H.1
Thougaard, A.V.2
Jensen, P.B.3
Sehested, M.4
-
13
-
-
78649947146
-
Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase
-
Olesen UH, Petersen JG, Garten A, Kiess W, Yoshino J, Imai SI, et al. Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase. BMC Cancer 2010;10:677.
-
(2010)
BMC Cancer
, vol.10
, pp. 677
-
-
Olesen, U.H.1
Petersen, J.G.2
Garten, A.3
Kiess, W.4
Yoshino, J.5
Imai, S.I.6
-
14
-
-
65349137584
-
Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas
-
Marquard L, Poulsen CB, Gjerdrum LM, de Nully Brown P, Christensen IJ, Jensen PB, et al. Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas. Histopathology 2009;54:688-98.
-
(2009)
Histopathology
, vol.54
, pp. 688-698
-
-
Marquard, L.1
Poulsen, C.B.2
Gjerdrum, L.M.3
de Nully Brown, P.4
Christensen, I.J.5
Jensen, P.B.6
-
15
-
-
0036856578
-
Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis
-
Rongvaux A, Shea RJ, Mulks MH, Gigot D, Urbain J, Leo O, et al. Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur J Immunol 2002;32:3225-34.
-
(2002)
Eur J Immunol
, vol.32
, pp. 3225-3234
-
-
Rongvaux, A.1
Shea, R.J.2
Mulks, M.H.3
Gigot, D.4
Urbain, J.5
Leo, O.6
-
16
-
-
0027958452
-
Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor
-
Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 1994;14:1431-7.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 1431-1437
-
-
Samal, B.1
Sun, Y.2
Stearns, G.3
Xie, C.4
Suggs, S.5
McNiece, I.6
-
17
-
-
0034802541
-
Signatures of the immune response
-
Shaffer AL, Rosenwald A, Hurt EM, Giltnane JM, Lam LT, Pickeral OK, et al. Signatures of the immune response. Immunity 2001;15:375-85.
-
(2001)
Immunity
, vol.15
, pp. 375-385
-
-
Shaffer, A.L.1
Rosenwald, A.2
Hurt, E.M.3
Giltnane, J.M.4
Lam, L.T.5
Pickeral, O.K.6
-
18
-
-
0033607212
-
Activation changes the spectrum but not the diversity of genes expressed by T cells
-
Teague TK, Hildeman D, Kedl RM, Mitchell T, Rees W, Schaefer BC, et al. Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Natl Acad Sci U S A 1999;96:12691-6.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 12691-12696
-
-
Teague, T.K.1
Hildeman, D.2
Kedl, R.M.3
Mitchell, T.4
Rees, W.5
Schaefer, B.C.6
-
19
-
-
0035315793
-
Gene regulation mediated by calcium signals in T lymphocytes
-
Feske S, Giltnane J, Dolmetsch R, Staudt LM, Rao A. Gene regulation mediated by calcium signals in T lymphocytes. Nat Immunol 2001;2:316-24.
-
(2001)
Nat Immunol
, vol.2
, pp. 316-324
-
-
Feske, S.1
Giltnane, J.2
Dolmetsch, R.3
Staudt, L.M.4
Rao, A.5
-
20
-
-
0037022296
-
Human macrophage activation programs induced by bacterial pathogens
-
Nau GJ, Richmond JF, Schlesinger A, Jennings EG, Lander ES, Young RA. Human macrophage activation programs induced by bacterial pathogens. Proc Natl Acad Sci U S A 2002;99:1503-8.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 1503-1508
-
-
Nau, G.J.1
Richmond, J.F.2
Schlesinger, A.3
Jennings, E.G.4
Lander, E.S.5
Young, R.A.6
-
21
-
-
0035955425
-
The plasticity of dendritic cell responses to pathogens and their components
-
Huang Q, Liu D, Majewski P, Schulte LC, Korn JM, Young RA, et al. The plasticity of dendritic cell responses to pathogens and their components. Science 2001;294:870-5.
-
(2001)
Science
, vol.294
, pp. 870-875
-
-
Huang, Q.1
Liu, D.2
Majewski, P.3
Schulte, L.C.4
Korn, J.M.5
Young, R.A.6
-
22
-
-
35848959692
-
Chemotherapy plus involved-field radiation in early-stage Hodgkin's disease
-
Ferme C, Eghbali H, Meerwaldt JH, Rieux C, Bosq J, Berger F, et al. Chemotherapy plus involved-field radiation in early-stage Hodgkin's disease. N Engl J Med 2007;357:1916-27.
-
(2007)
N Engl J Med
, vol.357
, pp. 1916-1927
-
-
Ferme, C.1
Eghbali, H.2
Meerwaldt, J.H.3
Rieux, C.4
Bosq, J.5
Berger, F.6
-
23
-
-
14844291424
-
Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3weeks in solid tumours: an ECSG/EORTC study
-
Ravaud A, Cerny T, Terret C, Wanders J, Bui BN, Hess D, et al. Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3weeks in solid tumours: an ECSG/EORTC study. Eur J Cancer 2005;41:702-7.
-
(2005)
Eur J Cancer
, vol.41
, pp. 702-707
-
-
Ravaud, A.1
Cerny, T.2
Terret, C.3
Wanders, J.4
Bui, B.N.5
Hess, D.6
-
24
-
-
38149105811
-
The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor
-
Holen K, Saltz LB, Hollywood E, Burk K, Hanauske AR. The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest New Drugs 2008;26:45-51.
-
(2008)
Invest New Drugs
, vol.26
, pp. 45-51
-
-
Holen, K.1
Saltz, L.B.2
Hollywood, E.3
Burk, K.4
Hanauske, A.R.5
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