Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis

Nature Communications

Volumn 4, Issue , 2013, Pages

  Annunziata, Ida ^a   Patterson, Annette ^a   Helton, Danielle ^a,b   Hu, Huimin ^a   Moshiach, Simon ^a   Gomero, Elida ^a   Nixon, Ralph ^c   D'Azzo, Alessandra ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; LYSOSOME ENZYME; NEURAMINIDASE 1; SIALIDASE; UNCLASSIFIED DRUG;

ACADEMIC RESEARCH; NEUROLOGY; NUMERICAL MODEL; PROTEIN; RODENT;

AMYLOID PLAQUE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFECT; EXOCYTOSIS; LYSOSOME; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN SECRETION;

MUS;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CALCIMYCIN; CELL LINE; DEPENDOVIRUS; EXOCYTOSIS; HIPPOCAMPUS; HUMANS; LYSOSOMES; MICE; MICE, TRANSGENIC; MUCOLIPIDOSES; NEURAMINIDASE; NEURONS; RISK FACTORS;

EID: 84889260626     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3734     Document Type: Article

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