Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 11, 2012, Pages 1989-2001

  André, Pascal ^a   Saubaméa, Bruno ^a   Cochois Guégan, Véronique ^a   Marie Claire, Cynthia ^a   Cattelotte, Julie ^a   Smirnova, Maria ^a   Schinkel, Alfred H ^b   Scherrmann, Jean Michel ^a,c   Cisternino, Salvatore ^a,c  

^a INSERM   (France)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

blood brain barrier; blood retina barrier; dopamine; neurovascular unit; organic cation transporters; uptake transporters

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; CARRIER PROTEIN; DOPAMINE; DOPAMINE TRANSPORTER; GLUCOSE TRANSPORTER 4; HISTAMINE; MESSENGER RNA; NEUROTRANSMITTER; NORADRENALIN TRANSPORTER; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 2; OCTAMER TRANSCRIPTION FACTOR 4; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; SEROTONIN; SEROTONIN TRANSPORTER; SLC47A1 PROTEIN; UNCLASSIFIED DRUG; UPTAKE1 TRANSPORTER; UPTAKE2 TRANSPORTER; XENOBIOTIC AGENT;

AMINE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD RETINA BARRIER; CATECHOLAMINE UPTAKE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE DELETION; IMMUNODETECTION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALGORITHMS; ANIMALS; BIOGENIC AMINES; BLOOD-BRAIN BARRIER; CAPILLARIES; CARRIER PROTEINS; CEREBRAL CORTEX; DOPAMINE; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICROSCOPY, CONFOCAL; NEURONS; NEUROTRANSMITTER AGENTS; POLYMERASE CHAIN REACTION; RETINA; RNA; SEROTONIN; TISSUE DISTRIBUTION;

EID: 84868545060     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.109     Document Type: Article

References (42)

1. Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ (2010) Structure and function of the blood-brain barrier. Neurobiol Dis 37:13-25
2. Amphoux A, Vialou V, Drescher E, Brü ss M, Mannoury La Cour C, Rochat C, Millan MJ, Giros B, Bönisch H, Gautron S (2006) Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology 50:941-52 (Pubitemid 43810126)
3. Brust P, Friedrich A, Krizbai IA, Bergmann R, Roux F, Ganapathy V, Johannsen B (2000) Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells. J Neurochem 74:1241-8 (Pubitemid 30104322)
4. Buck KJ, Amara SG (1994) Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium. Proc Natl Acad Sci USA 91:12584-8
5. Catravas JD, Gillis CN (1983) Single-pass removal of [14C]-5- hydroxytryptamine and [3H]norepinephrine by rabbit lung, in vivo: kinetics and sites of removal. J Pharmacol Exp Ther 224:28-33 (Pubitemid 13171025)
6. Cattelotte J, André P, Ouellet M, Bourasset F, Scherrmann JM, Cisternino S (2008) In situ mouse carotid perfusion model: glucose and cholesterol transport in the eye and brain. J Cereb Blood Flow Metab 28:1449-59
7. Chemuturi NV, Donovan MD (2007) Role of organic cation transporters in dopamine uptake across olfactory and nasal respiratory tissues. Mol Pharm 4:936-42
8. Dahlin A, Xia L, Kong W, Hevner R, Wang J (2007) Expression and immunolocalization of the plasma membrane monoamine transporter in the brain. Neuroscience 146:1193-211 (Pubitemid 46694120)
9. Daws LC (2009) Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy. Pharmacol Ther 121:89-99
10. Dickens D, Owen A, Alfirevic A, Giannoudis A, Davies A, Weksler B, Romero IA, Couraud PO, Pirmohamed M (2012) Lamotrigine is a substrate for OCT1 in brain endothelial cells. Biochem Pharmacol 83:805-14
11. Duan H, Wang J (2010) Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3. J Pharmacol Exp Ther 335:743-53
12. Eisenhofer G (2001) The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacol Ther 91:35-62 (Pubitemid 33055773)
13. Farag ES, Vinters HV, Bronstein J (2009) Pathologic findings in retinal pigment epithelial cell implantation for Parkinson disease. Neurology 73:1095-102
14. Friedrich A, George RL, Bridges CC, Prasad PD, Ganapathy V (2001) Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4). Biochim Biophys Acta 1512:299-307 (Pubitemid 32530777)
15. Ghersi-Egea JF, Minn A, Siest G (1988) A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels. Life Sci 42:2515-23
16. Koepsell H, Lips K, Volk C (2007) Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 24:1227-51 (Pubitemid 46876495)
17. Kristensen AS, Andersen J, Jørgensen TN, Sørensen L, Eriksen J, Loland CJ, Strømgaard K, Gether U (2011) SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacol Rev 63:585-640
18. Laties AM (1974) Ocular melanin and the adrenergic innervation to the eye. Trans Am Ophthalmol Soc 72: 560-605
19. Leybaert L (2005) Neurobarrier coupling in the brain: a partner of neurovascular and neurometabolic coupling? J Cereb Blood Flow Metab 25:2-16 (Pubitemid 40096893)
20. Lin CJ, Tai Y, Huang MT, Tsai YF, Hsu HJ, Tzen KY, Liou HH (2010) Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents. J Neurochem 114: 717-27
21. Liou HH, Hsu HJ, Tsai YF, Shih CY, Chang YC, Lin CJ (2007) Interaction between nicotine and MPTP/MPP+ in rat brain endothelial cells. Life Sci 81:664-72
22. Lu C, Diehl SA, Noubade R, Ledoux J, Nelson MT, Spach K, Zachary JF, Blankenhorn EP, Teuscher C (2010) Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis. Proc Natl Acad Sci USA 107:18967-72
23. Lyck R, Ruderisch N, Moll AG, Steiner O, Cohen CD, Engelhardt B, Makrides V, Verrey F (2009) Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo. J Cereb Blood Flow Metab 29:1491-502
24. Marie-Claire C, Courtin C, Roques BP, Noble F (2004) Cytoskeletal genes regulation by chronic morphine treatment in rat striatum. Neuropsychopharmacology 29:2208-15 (Pubitemid 39578911)
25. Matthies HJ, Han Q, Shields A, Wright J, Moore JL, Winder DG, Galli A, Blakely RD (2009) Subcellular localization of the antidepressant-sensitive norepinephrine transporter. BMC Neurosci 10:65
26. Ming M, Li X, Fan X, Yang D, Li L, Chen S, Gu Q, Le W (2009) Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease. J Transl Med 7:53-61
27. O'Kane RL, Martínez-López I, DeJoseph MR, Viñ a JR, Hawkins RA (1999) Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal. J Biol Chem 274:31891-5
28. OkuraT, Kato S, Takano Y, SatoT, YamashitaA,MorimotoR, Ohtsuki S, Terasaki T, Deguchi Y (2011) Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers. J Pharm Sci 100:3924-38
29. Oldendorf WH (1971) Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am J Physiol 221:1629-39
30. Pournaras CJ, Rungger-Brändle E, Riva CE, Hardarson SH, Stefansson E (2008) Regulation of retinal blood flow in health and disease. Prog Retin Eye Res 27:284-330
31. Rajan P, Kekuda R, Chancy CD, Huang W, Ganapathy V, Smith SB (2000) Expression of extraneuronal monomaine transporter in RPE and neural retina. Curr Eye Res 20:195-204 (Pubitemid 30209651)
32. Ramamoorthy S, Prasad PD, Kulanthaivel P, Leibach FH, Blakely RD, Ganapathy V (1993) Expression of a cocainesensitive norepinephrine transporter in the human placental syncytiotrophoblast. Biochemistry 32:1346-53 (Pubitemid 23070660)
33. Sager J, Torres G (2011) Proteins interacting with monoamine transporters: current state and future challenges. Biochemistry 50:7295-310
34. Shawahna R, Uchida Y, Decleves X, Ohtsuki S, Yousif S, Dauchy S, Jacob A, Chassoux F, Daumas-Duport C, Couraud PO, Terasaki T, Scherrmann JM (2011) Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm 8: 1332-1341
35. Smith QR (1996) Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system. Pharm Biotechnol 8:285-307
36. Takasato Y, Rapoport SI, Smith QR (1984) An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol 247:H484-93 (Pubitemid 14047362)
37. Ugrumov MV, Saifetyarova JY, Lavrentieva AV, Sapronova AY (2012) Developing brain as an endocrine organ: secretion of dopamine. Mol Cell Endocrinol 348:78-86
38. Urakami Y, Okuda M, Masuda S, Saito H, Inui KI (1998) Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther 287:800-5 (Pubitemid 29133685)
39. Vialou V, Amphoux A, Zwart R, Giros B, Gautron S (2004) Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation. J Neurosci 24:2846-51 (Pubitemid 38380963)
40. Wakayama K, Ohtsuki S, Takanaga H, Hosoya K, Terasaki T (2002) Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells. Neurosci Res 44:173-80 (Pubitemid 38365959)
41. Yousif S, Marie-Claire C, Roux F, Scherrmann JM, Declèves X (2007) Expression of drug transporters at the bloodbrain barrier using an optimized isolated rat brain microvessel strategy. Brain Res 1134:1-11 (Pubitemid 46156932)
42. Zhang T, Xiang CD, Gale D, Carreiro S, Wu EY, Zhang EY (2008) Drug transporter and cytochrome P450 mRNA expression in human ocular barriers: implications for ocular drug disposition. Drug Metab Dispos 36:1300-7 (Pubitemid 351929314)