Interplay of degradation, dissolution and stabilization of clarithromycin and its amorphous solid dispersions

Molecular Pharmaceutics

Volumn 10, Issue 12, 2013, Pages 4640-4653

  Pereira, Junia M ^a   Mejia Ariza, Raquel ^a   Ilevbare, Grace A ^b   McGettigan, Heather E ^a   Sriranganathan, Nammalwar ^a   Taylor, Lynne S ^b   Davis, Richey M ^a   Edgar, Kevin J ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

amorphous solid dispersion; CAAdP; cellulose ester; clarithromycin; CMCAB; flash nanoprecipitation; HPMCAS; multi inlet vortex mixer; nanoparticles; poorly soluble drugs

Indexed keywords

CELLULOSE DERIVATIVE; CLARITHROMYCIN; NANOPARTICLE;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDRODYNAMICS; HYDROPHOBICITY; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SMALL INTESTINE; SPRAY DRYING; STOMACH PH; THERMAL ANALYSIS; X RAY POWDER DIFFRACTION;

BIOLOGICAL AVAILABILITY; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CLARITHROMYCIN; CRYSTALLIZATION; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; NANOPARTICLES; POLYMERS; SOLUBILITY;

EID: 84889245760     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400441d     Document Type: Article

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