Application of ascorbic acid 2-glucoside as a solubilizing agent for clarithromycin: Solubilization and nanoparticle formation

International Journal of Pharmaceutics

Volumn 331, Issue 1, 2007, Pages 38-45

  Inoue, Yutaka ^a   Yoshimura, Sachie ^a   Tozuka, Yuichi ^b   Moribe, Kunikazu ^a   Kumamoto, Takuya ^a   Ishikawa, Tsutomu ^a   Yamamoto, Keiji ^a  

^a CHIBA UNIVERSITY   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Ascorbic acid 2 glucoside; Clarithromycin; Co grinding; Nanoparticle; Poorly water soluble drug; Solubilization

Indexed keywords

ASCORBIC ACID 2 GLUCOSIDE; ASCORBIC ACID DERIVATIVE; CARBON; CLARITHROMYCIN; GLUCOSIDE; KETONE; N,N DIMETHYL CARBON DERIVATIVE; N,N DIMETHYLAMINO DERIVATIVE; NANOPARTICLE; PHOSPHATE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DIET SUPPLEMENTATION; DISPERSION; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; DRUG STABILITY; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; SOLID STATE; ZETA POTENTIAL;

ANTI-BACTERIAL AGENTS; ASCORBIC ACID; CLARITHROMYCIN; DRUG COMPOUNDING; DRUG STABILITY; MAGNETIC RESONANCE SPECTROSCOPY; NANOPARTICLES; PARTICLE SIZE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 33846643594     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.09.014     Document Type: Article

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