Chronic atrial fibrillation alters the functional properties of I f in the human atrium

Journal of Cardiovascular Electrophysiology

Volumn 24, Issue 12, 2013, Pages 1391-1400

  Stillitano, Francesca ^a   Lonardo, Giuseppe ^a   Giunti, Gabriele ^b   Del Lungo, Martina ^a   Coppini, Raffaele ^a   Spinelli, Valentina ^a   Sartiani, Laura ^a   Poggesi, Corrado ^a   Mugelli, Alessandro ^a   Cerbai, Elisabetta ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

adrenergic stimulation; atrial fibrillation; atrial natriuretic peptide; hyperpolarization activated cyclic nucleotide gated channels; If; serotonin; valvular heart disease

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 1; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 2; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 4; MESSENGER RNA; MICRORNA 1; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; ELECTRIC POTENTIAL; FEMALE; GENE EXPRESSION; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE CONDUCTANCE; HEART MUSCLE FIBER MEMBRANE STEADY POTENTIAL; HEART SURGERY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINUS RHYTHM;

ATRIAL FIBRILLATION; ATRIAL NATRIURETIC PEPTIDE; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNELS; IF; SEROTONIN; VALVULAR HEART DISEASE; Β-ADRENERGIC STIMULATION;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ADULT; AGED; AGED, 80 AND OVER; ATRIAL FIBRILLATION; ATRIAL NATRIURETIC FACTOR; CHRONIC DISEASE; FEMALE; HEART ATRIA; HUMANS; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; MALE; MICRORNAS; MIDDLE AGED; MUSCLE PROTEINS; POTASSIUM CHANNELS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; SEROTONIN 5-HT4 RECEPTOR AGONISTS; TRANSCRIPTION, GENETIC;

EID: 84889100680     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/jce.12212     Document Type: Article

References (36)

1. American Heart Association: Guidelines for the management of atrial fibrillation. Eur Heart J 2010; 31: 2369-2429.
2. Belus A, Piroddi N, Ferrantini C, Tesi C, Cazorla O, Toniolo L, Drost M, Mearini G, Carrier L, Rossi A, Mugelli A, Cerbai E, van der Velden J, Poggesi C,: Effects of chronic atrial fibrillation on active and passive force generation in human atrial myofibrils. Circ Res 2010; 107: 144-152.
3. Nattel S, Maguy A, Le Bouter S, Yeh YH,: Arrhythmogenic ion-channel remodeling in the heart: Heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev 2007; 87: 425-456.
4. Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, Escande D, Nattel S, Demolombe S,: Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation 2005; 112: 471-481.
5. Nattel S, Frelin Y, Gaborit N, Louault C, Demolombe S,: Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates. J Mol Cell Cardiol 2010; 48: 96-105.
6. Biel M, Schneider A, Wahl C,: Cardiac HCN channels: Structure, function, and modulation. Trends Cardiovasc Med 2002; 12: 206-213.
7. DiFrancesco D,: Funny channels in the control of cardiac rhythm and mode of action of selective blockers. Pharmacol Res 2006; 53: 399-406.
8. Porciatti F, Pelzmann B, Cerbai E, Schaffer P, Pino R, Bernhart E, Koidl B, Mugelli A,: The pacemaker current If in single human atrial myocytes and the effect of beta-adrenoceptor and A1-adenosine receptor stimulation. Br J Pharmacol 1997; 122: 963-969.
9. Pino R, Cerbai E, Calamai G, Alajmo F, Borgioli A, Braconi L, Cassai M, Montesi GF, Mugelli A,: Effect of 5-HT4 receptor stimulation on the pacemaker current I(f) in human isolated atrial myocytes. Cardiovasc Res 1998; 40: 516-522.
10. Opthof T,: The membrane current If in human atrial cells: Implication for atrial arrhythmias. Cardiovasc Res 1998; 38: 537-540.
11. Lonardo G, Cerbai E, Casini S, Giunti G, Bonacchi M, Battaglia F, Fiorani B, Stefano PL, Sani G, Mugelli A,: Atrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytes. Cardiovasc Res 2004; 63: 528-536.
12. Lonardo G, Cerbai E, Casini S, Giunti G, Bonacchi M, Battaglia F, Fiorani B, Stefano PL, Sani G, Mugelli A,: Pharmacological modulation of the hyperpolarization-activated current (If) in human atrial myocytes: Focus on G protein-coupled receptors. J Mol Cell Cardiol 2005; 38: 453-460.
13. Lai LP, Su MJ, Lin JL, Tsai CH, Lin FY, Chen YS, Hwang JJ, Huang SK, Tseng YZ, Lien WP,: Measurement of funny current (I(f)) channel mRNA in human atrial tissue: Correlation with left atrial filling pressure and atrial fibrillation. J Cardiovasc Electrophysiol 1999; 10: 947-953.
14. Lezoualc'h F, Steplewski K, Sartiani L, Mugelli A, Fischmeister R, Bril A,: Quantitative mRNA analysis of serotonin 5-HT4 receptor isoforms, calcium handling proteins and ion channels in human atrial fibrillation. Biochem Biophys Res Commun 2007; 357: 218-224.
15. Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL, Wang DZ,: The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet 2006; 38: 228-233.
16. K1 up-regulation in human atrial fibrillation. Heart Rhythm 2009; 6: 1802-1809.
17. Stillitano F, Lonardo G, Zicha S, Varro A, Cerbai E, Mugelli A, Nattel S,: Molecular basis of funny current (If) in normal and failing human heart. J Mol Cell Cardiol 2008; 45: 289-299.
18. World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA 2000; 284: 3043-3045.
19. Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S, Ludwig A, Biel M,: Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem 2003; 278: 43781-43786.
20. 2-adrenergic receptor modulation of rate in sinoatrial myocytes. J Mol Cell Cardiol 2007; 42: 71-78.
21. Ye B, Balijepalli RC, Foell JD, Kroboth S, Ye Q, Luo YH, Shi NQ,: Caveolin-3 associates with and affects the function of hyperpolarization- activated cyclic nucleotide-gated channel 4. Biochemistry 2008; 47: 12312-12318.
22. Bosman A, Sartiani L, Spinelli V, Del Lungo M, Stillitano F, Nosi D, Mugelli A, Cerbai E, Jaconi M,: Molecular and functional evidence of hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) and caveolin-3 interaction during cardiomyocyte differentiation from human embryonic stem cells. Stem Cells Dev 2013; 22: 1717-1727.
23. Wang Z, Lu Y, Yang B,: MicroRNAs and atrial fibrillation: New fundamentals. Cardiovasc Res 2011; 89: 710-721.
24. DiFrancesco D,: Dual allosteric modulation of pacemaker (f) channels by cAMP and voltage in rabbit SA node. J Physiol 1999; 515: 367-376.
25. Ratajczak P, Damy T, Heymes C, Oliviéro P, Marotte F, Robidel E, Sercombe R, Boczkowski J, Rappaport L, Samuel JL,: Caveolin-1 and -3 dissociations from caveolae to cytosol in the heart during aging and after myocardial infarction in rat. Cardiovasc Res 2003; 57: 358-369.
26. Kim GH,: MicroRNA regulation of cardiac conduction and arrhythmias. Transl Res 2012; 161: 381-392.
27. f to cardiac arrhythmias. Circulation 2005; 111: 399-404.
28. f in human ventricular myocytes are modulated by cardiac disease. J Mol Cell Cardiol 2001; 33: 441-448.
29. Zhang Q, Huang A, Lin YC, Yu HG,: Associated changes in HCN2 and HCN4 transcripts and If pacemaker current in myocytes. Biochim Biophys Acta 2009; 1788: 1138-1147.
30. Musialek P, Rigg L, Terrar DA, Paterson DJ, Casadei B,: Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors. J Mol Cell Cardiol 2000; 32: 1831-1840.
31. Rozmaritsa N, Voigt N, Christ T, Wettwer E, Dobrev D, Ravens U,: Impaired nitric oxide regulation of L-type calcium current in patients with atrial fibrillation. Cardiovasc Res 2010; 87 (Suppl. 1): S51 (Abstract).
32. Kinoshita H, Kuwahara K, Nishida M, Jian Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose H, Inoue R, Mori Y, Li Y, Nakagawa Y, Usami S, Fujiwara M, Yamada Y, Minami T, Ueshima K, Nakao K,: Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. Circ Res 2010; 106: 1849-1860.
33. Wozakowska-Kaplon B, Opolski G, Herman Z, Kosior D,: Natriuretic peptides in patients with atrial fibrillation. Cardiol J 2008; 15: 525-529.
34. Cody RJ, Atlas SA, Laragh JH, Kubo SH, Covit AB, Ryman KS, Shaknovich A, Pondolfino K, Clark M, Camargo MJ,: Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion. J Clin Invest 1986; 78: 1362-1374.
35. Workman A,: Cardiac adrenergic control and atrial fibrillation. Naunyn-Schmiedeberg's Archiv Pharmacol 2010; 381: 235-249.
36. Yeh YH, Burstein B, Qi XY, Sakabe M, Chartier D, Comtois P, Wang Z, Kuo CT, Nattel S,: Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: A molecular basis for tachycardia-bradycardia syndrome. Circulation 2009; 119: 1576-1585.