Understanding the in vivo performance of enteric coated tablets using an in vitro-in silico-in vivo approach: Case example diclofenac

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART B, 2013, Pages 1337-1347

  Kambayashi, Atsushi ^a,c   Blume, Henning ^b   Dressman, Jennifer ^a  

^a GOETHE UNIVERSITY   (Germany)

^b SocraTec R and D GmbH   (Germany)

^c ASTELLAS PHARMA INC   (Japan)

Author keywords

Biorelevant media; Diclofenac; Modeling and simulation; Monolithic enteric coated tablet; Oral administration; Pharmacokinetics

Indexed keywords

DICLOFENAC;

ARTICLE; BIOEQUIVALENCE; COMPUTER MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; DISSOLUTION; DRUG BLOOD LEVEL; DRUG DOSAGE FORM; DRUG SOLUBILITY; ENTERIC COATED TABLET; GASTROINTESTINAL TRANSIT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INGESTION; STOMACH EMPTYING;

BIORELEVANT MEDIA; DICLOFENAC; MODELING AND SIMULATION; MONOLITHIC ENTERIC COATED TABLET; ORAL ADMINISTRATION; PHARMACOKINETICS;

BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; DICLOFENAC; DOSAGE FORMS; FASTING; FEMALE; FOOD-DRUG INTERACTIONS; GASTRIC EMPTYING; GASTROINTESTINAL TRANSIT; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; KINETICS; MALE; PHARMACEUTICAL PREPARATIONS; SOFTWARE; SOLUBILITY; TABLETS; TABLETS, ENTERIC-COATED; TECHNOLOGY, PHARMACEUTICAL;

EID: 84889100589     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.09.009     Document Type: Article

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