Mechanistic understanding of time-dependent oral absorption based on gastric motor activity in humans

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 1, 2008, Pages 313-325

  Higaki, Kazutaka ^a   Choe, Sally Y ^a   Löbenberg, Raimar ^a   Welage, Lynda S ^a,b   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN HOSPITALS   (United States)

Author keywords

Absorption rate; Absorption rate constant; Caffeine; Fed state; Gastric emptying; Gastric motor activity; Plasma concentration time profile; Time dependent absorption

Indexed keywords

CAFFEINE; HYDROXYPROPYLMETHYLCELLULOSE;

ADULT; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG PELLET; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; STOMACH EMPTYING; STOMACH MOTILITY; TIME;

ADMINISTRATION, ORAL; ADULT; CAFFEINE; FEMALE; GASTRIC EMPTYING; GASTROINTESTINAL MOTILITY; HUMANS; INTESTINAL ABSORPTION; MALE; MODELS, BIOLOGICAL; MYOELECTRIC COMPLEX, MIGRATING; POSTPRANDIAL PERIOD; PYLORIC ANTRUM; TABLETS, ENTERIC-COATED;

EID: 50149090855     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.02.022     Document Type: Article

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