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Volumn 13, Issue 10, 2013, Pages 1506-1522

Tumor-receptor imaging in breast cancer: A tool for patient selection and response monitoring

Author keywords

Breast cancer; Molecular imaging; Patient selection; Pet; Response monitoring; Spect

Indexed keywords

4 (3 BROMOANILINO) 6, 7 DIMETHOXYQUINAZOLINE; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANASTROZOLE; ANTHRACYCLINE; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CHEMOKINE RECEPTOR CXCR4; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; ESTROGEN RECEPTOR; FIBRONECTIN RECEPTOR; FULVESTRANT; GEFITINIB; LAPATINIB; LETROZOLE; N (3 CHLOROPHENYL) 3 [3, 5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2, 3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; N (3 CHLOROPHENYL) 3 [3,5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2,3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; PACLITAXEL; PANITUMUMAB; PERTUZUMAB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROGESTERONE RECEPTOR; SOMATOMEDIN C RECEPTOR; SORAFENIB; TAMOXIFEN; TRACER; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN RECEPTOR 1; VITRONECTIN RECEPTOR;

EID: 84889076059     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524013666131111120638     Document Type: Review
Times cited : (8)

References (166)
  • 1
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for earlybreast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Effects of chemotherapy and hormonal therapy for earlybreast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 365: 1687-717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 2
    • 34547661993 scopus 로고    scopus 로고
    • Triple-negative breastcancer: Clinical features and patterns of recurrence
    • Dent R, Trudeau M, Pritchard KI, et al. Triple-negative breastcancer: clinical features and patterns of recurrence. Clin Cancer Res 2007; 13: 4429-34.
    • (2007) Clin Cancer Res , vol.13 , pp. 4429-4434
    • Dent, R.1    Trudeau, M.2    Pritchard, K.I.3
  • 3
    • 84855410318 scopus 로고    scopus 로고
    • Imaging ofInsulinlike Growth Factor Type 1 Receptor in Prostate Cancer Xenografts Using the Affibody Molecule 111In-DOTA-ZIGF1R:4551
    • Tolmachev V, Malmberg J, Hofstrom C, et al. Imaging ofInsulinlike Growth Factor Type 1 Receptor in Prostate Cancer Xenografts Using the Affibody Molecule 111In-DOTA-ZIGF1R:4551. J Nucl Med 2012; 53: 90-7.
    • (2012) J Nucl Med , vol.53 , pp. 90-97
    • Tolmachev, V.1    Malmberg, J.2    Hofstrom, C.3
  • 4
    • 63849193777 scopus 로고    scopus 로고
    • The role of radiotracerimaging in the diagnosis and management of patients with breast cancer: Part 1-overview, detection, and staging
    • Lee JH, Rosen EL, Mankoff DA. The role of radiotracerimaging in the diagnosis and management of patients with breast cancer: part 1-overview, detection, and staging. J Nucl Med 2009; 50: 569-81.
    • (2009) J Nucl Med , vol.50 , pp. 569-581
    • Lee, J.H.1    Rosen, E.L.2    Mankoff, D.A.3
  • 5
    • 66149144397 scopus 로고    scopus 로고
    • The role of radiotracerimaging in the diagnosis and management of patients withbreast cancer: Part 2-response to therapy, other indications, and future directions
    • Lee JH, Rosen EL, Mankoff DA. The role of radiotracerimaging in the diagnosis and management of patients withbreast cancer: part 2-response to therapy, other indications, and future directions. J Nucl Med 2009; 50: 738-48.
    • (2009) J Nucl Med , vol.50 , pp. 738-748
    • Lee, J.H.1    Rosen, E.L.2    Mankoff, D.A.3
  • 6
    • 4944266313 scopus 로고    scopus 로고
    • High interstitialfluid pressure-an obstacle in cancer therapy
    • Heldin CH, Rubin K, Pietras K, Ostman A. High interstitialfluid pressure-an obstacle in cancer therapy. Nat Rev Cancer 2004; 4: 806-13.
    • (2004) Nat Rev Cancer , vol.4 , pp. 806-813
    • Heldin, C.H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 7
    • 0033302303 scopus 로고    scopus 로고
    • Transport of molecules, particles, and cells in solidtumors
    • Jain RK. Transport of molecules, particles, and cells in solidtumors. Annu Rev Biomed Eng 1999; 1: 241-63.
    • (1999) Annu Rev Biomed Eng , vol.1 , pp. 241-263
    • Jain, R.K.1
  • 8
    • 0037089544 scopus 로고    scopus 로고
    • Antihuman epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab enhances cytolytic activity of class I-restricted HER2-specific T lymphocytes against HER2-overexpressing tumor cells
    • zum Buschenfelde CM, Hermann C, Schmidt B, Peschel C, Bernhard H. Antihuman epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab enhances cytolytic activity of class I-restricted HER2-specific T lymphocytes against HER2-overexpressing tumor cells. Cancer Res 2002; 62: 2244-7.
    • (2002) Cancer Res , vol.62 , pp. 2244-2247
    • Zum, B.C.M.1    Hermann, C.2    Schmidt, B.3    Peschel, C.4    Bernhard, H.5
  • 9
    • 1842684035 scopus 로고    scopus 로고
    • Fulvestrant: Anoestrogen receptor antagonist with a novel mechanism of action
    • Osborne CK, Wakeling A, Nicholson RI. Fulvestrant: anoestrogen receptor antagonist with a novel mechanism of action. Br J Cancer 2004; 90 Suppl 1: S2-6.
    • (2004) Br J Cancer , vol.90 , Issue.SUPPL. 1
    • Osborne, C.K.1    Wakeling, A.2    Nicholson, R.I.3
  • 10
    • 84859377878 scopus 로고    scopus 로고
    • Potentialof PET to Predict the Response to Trastuzumab Treatment in an ErbB2-Positive Human Xenograft Tumor Model
    • Kramer-Marek G, Gijsen M, Kiesewetter DO, et al. Potentialof PET to Predict the Response to Trastuzumab Treatment in an ErbB2-Positive Human Xenograft Tumor Model. J Nucl Med 2012.
    • (2012) J Nucl Med
    • Kramer-Marek, G.1    Gijsen, M.2    Kiesewetter, D.O.3
  • 12
    • 0036838070 scopus 로고    scopus 로고
    • Estrogen receptor breast cancer phenotypes in the Surveillance, Epidemiology, and End Results database
    • Anderson WF, Chatterjee N, Ershler WB, Brawley OW. Estrogen receptor breast cancer phenotypes in the Surveillance, Epidemiology, and End Results database. Breast Cancer ResTreat 2002; 76: 27-36.
    • (2002) Breast Cancer ResTreat , vol.76 , pp. 27-36
    • Anderson, W.F.1    Chatterjee, N.2    Ershler, W.B.3    Brawley, O.W.4
  • 13
    • 79960832381 scopus 로고    scopus 로고
    • The different roles of ERsubtypes in cancer biology and therapy
    • Thomas C, Gustafsson JA. The different roles of ERsubtypes in cancer biology and therapy. Nat Rev Cancer 2011; 11: 597-608.
    • (2011) Nat Rev Cancer , vol.11 , pp. 597-608
    • Thomas, C.1    Gustafsson, J.A.2
  • 14
    • 77954526150 scopus 로고    scopus 로고
    • AmericanSociety of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer
    • Hammond ME, Hayes DF, Dowsett M, et al. AmericanSociety of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Clin Oncol 2010; 28: 2784-95.
    • (2010) J Clin Oncol , vol.28 , pp. 2784-2795
    • Hammond, M.E.1    Hayes, D.F.2    Dowsett, M.3
  • 16
    • 0029781863 scopus 로고    scopus 로고
    • Loss ofestrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy
    • Kuukasjarvi T, Kononen J, Helin H, Holli K, Isola J. Loss ofestrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy. J Clin Oncol 1996; 14: 2584-9.
    • (1996) J Clin Oncol , vol.14 , pp. 2584-2589
    • Kuukasjarvi, T.1    Kononen, J.2    Helin, H.3    Holli, K.4    Isola, J.5
  • 17
    • 0026487215 scopus 로고
    • Sequential estrogenreceptor determinations from primary breast cancer and at relapse: Prognostic and therapeutic relevance
    • The International Breast Cancer Study Group (formerly Ludwig Group)
    • Spataro V, Price K, Goldhirsch A, et al. Sequential estrogenreceptor determinations from primary breast cancer and at relapse: prognostic and therapeutic relevance. The International Breast Cancer Study Group (formerly Ludwig Group). Ann Oncol 1992; 3: 733-40.
    • (1992) Ann Oncol , vol.3 , pp. 733-740
    • Spataro, V.1    Price, K.2    Goldhirsch, A.3
  • 19
    • 0028799039 scopus 로고
    • Positrontomographic assessment of estrogen receptors in breast cancer: Comparison with FDG-PET and in vitro receptor assays
    • Dehdashti F, Mortimer JE, Siegel BA, et al. Positrontomographic assessment of estrogen receptors in breast cancer: comparison with FDG-PET and in vitro receptor assays. J Nucl Med 1995; 36: 1766-74.
    • (1995) J Nucl Med , vol.36 , pp. 1766-1774
    • Dehdashti, F.1    Mortimer, J.E.2    Siegel, B.A.3
  • 20
    • 40449093680 scopus 로고    scopus 로고
    • Quantitativeimaging of estrogen receptor expression in breast cancer with PET and 18F-fluoroestradiol
    • Peterson LM, Mankoff DA, Lawton T, et al. Quantitativeimaging of estrogen receptor expression in breast cancer with PET and 18F-fluoroestradiol. J Nucl Med 2008; 49: 367-74.
    • (2008) J Nucl Med , vol.49 , pp. 367-374
    • Peterson, L.M.1    Mankoff, D.A.2    Lawton, T.3
  • 21
    • 0029979129 scopus 로고    scopus 로고
    • Positron emission tomography with 2-[18F]Fluoro-2-deoxy-D-glucose and 16alpha-[18F]fluoro-17beta-estradiol in breast cancer: Correlation with estrogen receptor status and response to systemic therapy
    • Mortimer JE, Dehdashti F, Siegel BA, Katzenellenbogen JA, Fracasso P, Welch MJ. Positron emission tomography with 2-[18F]Fluoro-2-deoxy-D-glucose and 16alpha-[18F]fluoro-17beta-estradiol in breast cancer: correlation with estrogen receptor status and response to systemic therapy. Clin Cancer Res 1996; 2: 933-9.
    • (1996) Clin Cancer Res , vol.2 , pp. 933-939
    • Mortimer, J.E.1    Dehdashti, F.2    Siegel, B.A.3    Katzenellenbogen, J.A.4    Fracasso, P.5    Welch, M.J.6
  • 22
    • 0025938256 scopus 로고
    • Positrontomographic assessment of 16 alpha-[18F] fluoro-17 betaestradiol uptake in metastatic breast carcinoma
    • McGuire AH, Dehdashti F, Siegel BA, et al. Positrontomographic assessment of 16 alpha-[18F] fluoro-17 betaestradiol uptake in metastatic breast carcinoma. J Nucl Med 1991; 32: 1526-31.
    • (1991) J Nucl Med , vol.32 , pp. 1526-1531
    • McGuire, A.H.1    Dehdashti, F.2    Siegel, B.A.3
  • 23
    • 33745545477 scopus 로고    scopus 로고
    • Quantitativefluoroestradiol positron emission tomography imaging predicts response to endocrine treatment in breast cancer
    • Linden HM, Stekhova SA, Link JM, et al. Quantitativefluoroestradiol positron emission tomography imaging predicts response to endocrine treatment in breast cancer. J Clin Oncol 2006; 24: 2793-9.
    • (2006) J Clin Oncol , vol.24 , pp. 2793-2799
    • Linden, H.M.1    Stekhova, S.A.2    Link, J.M.3
  • 25
    • 0033024916 scopus 로고    scopus 로고
    • Positron emission tomographic assessment of metabolic flare to predict response of metastatic breast cancer to antiestrogen therapy
    • Dehdashti F, Flanagan FL, Mortimer JE, Katzenellenbogen JA, Welch MJ, Siegel BA. Positron emission tomographic assessment of metabolic flare to predict response of metastatic breast cancer to antiestrogen therapy. Eur J Nucl Med 1999; 26: 51-6.
    • (1999) Eur J Nucl Med , vol.26 , pp. 51-56
    • Dehdashti, F.1    Flanagan, F.L.2    Mortimer, J.E.3    Katzenellenbogen, J.A.4    Welch, M.J.5    Siegel, B.A.6
  • 26
    • 58549097114 scopus 로고    scopus 로고
    • PET-basedestradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer
    • Dehdashti F, Mortimer JE, Trinkaus K, et al. PET-basedestradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer. Breast Cancer Res Treat 2009; 113: 509-17.
    • (2009) Breast Cancer Res Treat , vol.113 , pp. 509-517
    • Dehdashti, F.1    Mortimer, J.E.2    Trinkaus, K.3
  • 27
    • 79960428275 scopus 로고    scopus 로고
    • Fluoroestradiolpositron emission tomography reveals differences in pharmacodynamics of aromatase inhibitors, tamoxifen, and fulvestrant in patients with metastatic breast cancer
    • Linden HM, Kurland BF, Peterson LM, et al. Fluoroestradiolpositron emission tomography reveals differences in pharmacodynamics of aromatase inhibitors, tamoxifen, and fulvestrant in patients with metastatic breast cancer. Clin Cancer Res 2011; 17: 4799-805.
    • (2011) Clin Cancer Res , vol.17 , pp. 4799-4805
    • Linden, H.M.1    Kurland, B.F.2    Peterson, L.M.3
  • 28
    • 84856790756 scopus 로고    scopus 로고
    • PETImaging of Estrogen Receptors as a Diagnostic Tool for Breast Cancer Patients Presenting with a Clinical Dilemma
    • van Kruchten M, Glaudemans AW, de Vries EF, et al. PETImaging of Estrogen Receptors as a Diagnostic Tool for Breast Cancer Patients Presenting with a Clinical Dilemma. J Nucl Med 2012.
    • (2012) J Nucl Med
    • van Kruchten, M.1    Glaudemans, A.W.2    de Vries, E.F.3
  • 29
    • 0030790124 scopus 로고    scopus 로고
    • Imaging ofestrogen receptors in primary and metastatic breast cancer patients with iodine-123-labeled Z-MIVE
    • Rijks LJ, Bakker PJ, van Tienhoven G, et al. Imaging ofestrogen receptors in primary and metastatic breast cancer patients with iodine-123-labeled Z-MIVE. J Clin Oncol 1997; 15: 2536-45.
    • (1997) J Clin Oncol , vol.15 , pp. 2536-2545
    • Rijks, L.J.1    Bakker, P.J.2    van Tienhoven, G.3
  • 30
    • 0030907782 scopus 로고    scopus 로고
    • The Z-isomer of 11 beta-methoxy-17 alpha-[123I]iodovinylestradiol is a promising radioligand for estrogen receptor imaging in human breast cancer
    • Rijks LJ, Boer GJ, Endert E, de Bruin K, Janssen AG, vanRoyen EA. The Z-isomer of 11 beta-methoxy-17 alpha-[123I]iodovinylestradiol is a promising radioligand for estrogen receptor imaging in human breast cancer. Nucl Med Biol 1997; 24: 65-75.
    • (1997) Nucl Med Biol , vol.24 , pp. 65-75
    • Rijks, L.J.1    Boer, G.J.2    Endert, E.3    de Bruin, K.4    Janssen, A.G.5    Vanroyen, E.A.6
  • 31
    • 0034877612 scopus 로고    scopus 로고
    • Estrogen receptor status in primary breast cancer: Iodine 123-labeled cis-11beta-methoxy-17alpha-iodovinyl estradiol scintigraphy
    • Bennink RJ, Rijks LJ, van Tienhoven G, Noorduyn LA, Janssen AG, Sloof GW. Estrogen receptor status in primary breast cancer: iodine 123-labeled cis-11beta-methoxy-17alpha-iodovinyl estradiol scintigraphy. Radiology 2001; 220: 774-9.
    • (2001) Radiology , vol.220 , pp. 774-779
    • Bennink, R.J.1    Rijks, L.J.2    van Tienhoven, G.3    Noorduyn, L.A.4    Janssen, A.G.5    Sloof, G.W.6
  • 33
    • 80053509282 scopus 로고    scopus 로고
    • Between-patient andwithin-patient (site-to-site) variability in estrogen receptor binding, measured in vivo by 18F-fluoroestradiol PET
    • Kurland BF, Peterson LM, Lee JH, et al. Between-patient andwithin-patient (site-to-site) variability in estrogen receptor binding, measured in vivo by 18F-fluoroestradiol PET. J Nucl Med 2011; 52: 1541-9.
    • (2011) J Nucl Med , vol.52 , pp. 1541-1549
    • Kurland, B.F.1    Peterson, L.M.2    Lee, J.H.3
  • 34
    • 0018175970 scopus 로고
    • Estrogen control ofprogesterone receptor in human breast cancer: Role of estradiol and antiestrogen
    • Horwitz KB, Koseki Y, McGuire WL. Estrogen control ofprogesterone receptor in human breast cancer: role of estradiol and antiestrogen. Endocrinology 1978; 103: 1742-51.
    • (1978) Endocrinology , vol.103 , pp. 1742-1751
    • Horwitz, K.B.1    Koseki, Y.2    McGuire, W.L.3
  • 35
    • 0036838070 scopus 로고    scopus 로고
    • Estrogen receptor breast cancer phenotypes in the Surveillance, Epidemiology, and End Results database
    • Anderson WF, Chatterjee N, Ershler WB, Brawley OW. Estrogen receptor breast cancer phenotypes in the Surveillance, Epidemiology, and End Results database. Breast Cancer Res Treat 2002; 76: 27-36.
    • (2002) Breast Cancer Res Treat , vol.76 , pp. 27-36
    • Anderson, W.F.1    Chatterjee, N.2    Ershler, W.B.3    Brawley, O.W.4
  • 36
    • 36048980544 scopus 로고    scopus 로고
    • Biologic andclinical characteristics of breast cancer with single hormone receptor positive phenotype
    • Rakha EA, El-Sayed ME, Green AR, et al. Biologic andclinical characteristics of breast cancer with single hormone receptor positive phenotype. J Clin Oncol 2007; 25: 4772-8.
    • (2007) J Clin Oncol , vol.25 , pp. 4772-4778
    • Rakha, E.A.1    El-Sayed, M.E.2    Green, A.R.3
  • 37
    • 0038688478 scopus 로고    scopus 로고
    • Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases
    • Bardou VJ, Arpino G, Elledge RM, Osborne CK, Clark GM. Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases. J Clin Oncol 2003; 21: 1973-9.
    • (2003) J Clin Oncol , vol.21 , pp. 1973-1979
    • Bardou, V.J.1    Arpino, G.2    Elledge, R.M.3    Osborne, C.K.4    Clark, G.M.5
  • 38
    • 0028171496 scopus 로고
    • Metabolism of a [18F]fluorine labeled progestin (21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone) in humans: A clue for future investigations
    • Verhagen A, Studeny M, Luurtsema G, et al. Metabolism of a [18F]fluorine labeled progestin (21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone) in humans: a clue for future investigations. Nucl Med Biol 1994; 21: 941-52.
    • (1994) Nucl Med Biol , vol.21 , pp. 941-952
    • Verhagen, A.1    Studeny, M.2    Luurtsema, G.3
  • 39
    • 0025925231 scopus 로고
    • Assessment of 21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone as a positron-emitting radiopharmaceutical for the detection of progestin receptors in human breast carcinomas
    • Dehdashti F, McGuire AH, Van Brocklin HF, et al. Assessment of 21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone as a positron-emitting radiopharmaceutical for the detection of progestin receptors in human breast carcinomas. J Nucl Med 1991; 32: 1532-7.
    • (1991) J Nucl Med , vol.32 , pp. 1532-1537
    • Dehdashti, F.1    McGuire, A.H.2    van Brocklin, H.F.3
  • 40
    • 77953642584 scopus 로고    scopus 로고
    • Development of [F-18]fluorine-substituted Tanaproget as a progesterone receptor imaging agent for positron emission tomography
    • Lee JH, Zhou HB, Dence CS, Carlson KE, Welch MJ, Katzenellenbogen JA. Development of [F-18]fluorine-substituted Tanaproget as a progesterone receptor imaging agent for positron emission tomography. Bioconjug Chem 2010; 21: 1096-104.
    • (2010) Bioconjug Chem , vol.21 , pp. 1096-1104
    • Lee, J.H.1    Zhou, H.B.2    Dence, C.S.3    Carlson, K.E.4    Welch, M.J.5    Katzenellenbogen, J.A.6
  • 41
    • 33746684273 scopus 로고    scopus 로고
    • Bromine-and iodine-substituted 16alpha,17alpha-dioxolane progestins for breast tumor imaging and radiotherapy: Synthesis and receptor binding affinity
    • Zhou D, Carlson KE, Katzenellenbogen JA, Welch MJ. Bromine-and iodine-substituted 16alpha,17alpha-dioxolane progestins for breast tumor imaging and radiotherapy: synthesis and receptor binding affinity. J Med Chem 2006; 49: 4737-44.
    • (2006) J Med Chem , vol.49 , pp. 4737-4744
    • Zhou, D.1    Carlson, K.E.2    Katzenellenbogen, J.A.3    Welch, M.J.4
  • 42
    • 84858588947 scopus 로고    scopus 로고
    • Assessment ofProgesterone Receptors in Breast Carcinoma by PET with 21-18F-Fluoro-16alpha,17alpha-[(R)-(1'-alpha-furylmethylidene)Dioxy]-19-Norpregn-4-Ene-3,20-Dione
    • Dehdashti F, Laforest R, Gao F, et al. Assessment ofProgesterone Receptors in Breast Carcinoma by PET with 21-18F-Fluoro-16alpha,17alpha-[(R)-(1'-alpha-furylmethylidene)Dioxy]-19-Norpregn-4-Ene-3,20-Dione. J Nucl Med 2012; 53: 363-70.
    • (2012) J Nucl Med , vol.53 , pp. 363-370
    • Dehdashti, F.1    Laforest, R.2    Gao, F.3
  • 43
    • 67649472398 scopus 로고    scopus 로고
    • Novel anticancer targets: RevisitingERBB2 and discovering ERBB3
    • Baselga J, Swain SM. Novel anticancer targets: revisitingERBB2 and discovering ERBB3. Nat Rev Cancer 2009; 9: 463-75.
    • (2009) Nat Rev Cancer , vol.9 , pp. 463-475
    • Baselga, J.1    Swain, S.M.2
  • 44
    • 33751295869 scopus 로고    scopus 로고
    • Advances in targeting humanepidermal growth factor receptor-2 signaling for cancer therapy
    • Meric-Bernstam F, Hung MC. Advances in targeting humanepidermal growth factor receptor-2 signaling for cancer therapy. Clin Cancer Res 2006; 12: 6326-30.
    • (2006) Clin Cancer Res , vol.12 , pp. 6326-6330
    • Meric-Bernstam, F.1    Hung, M.C.2
  • 45
    • 26844457534 scopus 로고    scopus 로고
    • The distinctive nature of HER2-positive breastcancers
    • Burstein HJ. The distinctive nature of HER2-positive breastcancers. N Engl J Med 2005; 353: 1652-4.
    • (2005) N Engl J Med , vol.353 , pp. 1652-1654
    • Burstein, H.J.1
  • 46
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab incombination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • Bang YJ, Van CE, Feyereislova A, et al. Trastuzumab incombination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010; 376: 687-97.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van, C.E.2    Feyereislova, A.3
  • 47
    • 22344446208 scopus 로고    scopus 로고
    • Randomized phaseII trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
    • Marty M, Cognetti F, Maraninchi D, et al. Randomized phaseII trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol 2005; 23: 4265-74.
    • (2005) J Clin Oncol , vol.23 , pp. 4265-4274
    • Marty, M.1    Cognetti, F.2    Maraninchi, D.3
  • 48
    • 0035869407 scopus 로고    scopus 로고
    • Use ofchemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use ofchemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001; 344: 783-92.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 49
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib pluscapecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib pluscapecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006; 355: 2733-43.
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 50
    • 36849069347 scopus 로고    scopus 로고
    • American Society ofClinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
    • Harris L, Fritsche H, Mennel R, et al. American Society ofClinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol 2007; 25: 5287-312.
    • (2007) J Clin Oncol , vol.25 , pp. 5287-5512
    • Harris, L.1    Fritsche, H.2    Mennel, R.3
  • 51
    • 34548017672 scopus 로고    scopus 로고
    • Inconsistency of HER2 test raises questions
    • Tuma RS. Inconsistency of HER2 test raises questions. JNatl Cancer Inst 2007; 99: 1064-5.
    • (2007) JNatl Cancer Inst , vol.99 , pp. 1064-1065
    • Tuma, R.S.1
  • 52
    • 33847147313 scopus 로고    scopus 로고
    • AmericanSociety of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • Wolff AC, Hammond ME, Schwartz JN, et al. AmericanSociety of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 2007; 25: 118-45.
    • (2007) J Clin Oncol , vol.25 , pp. 118-145
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3
  • 53
    • 58149237085 scopus 로고    scopus 로고
    • HER-2/neuexpression in primary and metastatic breast cancer
    • Lower EE, Glass E, Blau R, Harman S. HER-2/neuexpression in primary and metastatic breast cancer. Breast Cancer Res Treat 2009; 113: 301-6.
    • (2009) Breast Cancer Res Treat , vol.113 , pp. 301-306
    • Lower, E.E.1    Glass, E.2    Blau, R.3    Harman, S.4
  • 54
    • 26944465031 scopus 로고    scopus 로고
    • Comparison of HER-2 overexpression in primary breast cancer and metastatic sites and its effect on biological targeting therapy of metastatic disease
    • Zidan J, Dashkovsky I, Stayerman C, Basher W, Cozacov C, Hadary A. Comparison of HER-2 overexpression in primary breast cancer and metastatic sites and its effect on biological targeting therapy of metastatic disease. Br J Cancer 2005; 93: 552-6.
    • (2005) Br J Cancer , vol.93 , pp. 552-556
    • Zidan, J.1    Dashkovsky, I.2    Stayerman, C.3    Basher, W.4    Cozacov, C.5    Hadary, A.6
  • 55
    • 33744831505 scopus 로고    scopus 로고
    • Indium-111-labeled trastuzumab scintigraphy in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
    • Perik PJ, Lub-De Hooge MN, Gietema JA, et al. Indium-111-labeled trastuzumab scintigraphy in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 2006; 24: 2276-82.
    • (2006) J Clin Oncol , vol.24 , pp. 2276-2282
    • Perik, P.J.1    Lub-De, H.M.N.2    Gietema, J.A.3
  • 56
    • 77951474500 scopus 로고    scopus 로고
    • Biodistribution of 89Zr-trastuzumab and PET imaging of HER2-positive lesions in patients with metastatic breast cancer
    • Dijkers EC, Oude Munnink TH, Kosterink JG, et al. Biodistribution of 89Zr-trastuzumab and PET imaging of HER2-positive lesions in patients with metastatic breast cancer. Clin Pharmacol Ther 2010; 87: 586-92.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 586-592
    • Dijkers, E.C.1    Oude, M.T.H.2    Kosterink, J.G.3
  • 57
    • 34548481766 scopus 로고    scopus 로고
    • 111Indium-trastuzumab visualises myocardial human epidermal growth factor receptor 2 expression shortly after anthracycline treatment but not during heart failure: A clue to uncover the mechanisms of trastuzumab-related cardiotoxicity
    • de Korte MA, de Vries EG, Lub-de Hooge MN, et al. 111Indium-trastuzumab visualises myocardial human epidermal growth factor receptor 2 expression shortly after anthracycline treatment but not during heart failure: a clue to uncover the mechanisms of trastuzumab-related cardiotoxicity. Eur J Cancer 2007; 43: 2046-51.
    • (2007) Eur J Cancer , vol.43 , pp. 2046-2051
    • de Korte, M.A.1    de Vries, E.G.2    Lub-De, H.M.N.3
  • 60
    • 68249157963 scopus 로고    scopus 로고
    • Micro-SPECT/CT with111In-DTPA-pertuzumab sensitively detects trastuzumabmediated HER2 downregulation and tumor response in athymic mice bearing MDA-MB-361 human breast cancer xenografts
    • McLarty K, Cornelissen B, Cai Z, et al. Micro-SPECT/CT with111In-DTPA-pertuzumab sensitively detects trastuzumabmediated HER2 downregulation and tumor response in athymic mice bearing MDA-MB-361 human breast cancer xenografts. J Nucl Med 2009; 50: 1340-8.
    • (2009) J Nucl Med , vol.50 , pp. 1340-1348
    • McLarty, K.1    Cornelissen, B.2    Cai, Z.3
  • 62
    • 77957300462 scopus 로고    scopus 로고
    • Positron emissiontomography (PET) with radiolabeled F(ab')2-trastuzumab fragments in patients (pts) with HER2-positive metastatic breast cancer (MBC): Initial feasibility results
    • Akhurst T, Morris PG, Modi S, et al. Positron emissiontomography (PET) with radiolabeled F(ab')2-trastuzumab fragments in patients (pts) with HER2-positive metastatic breast cancer (MBC): Initial feasibility results. Breast Cancer Symposium 2008.
    • (2008) Breast Cancer Symposium
    • Akhurst, T.1    Morris, P.G.2    Modi, S.3
  • 63
    • 77953130101 scopus 로고    scopus 로고
    • Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications
    • Lofblom J, Feldwisch J, Tolmachev V, Carlsson J, Stahl S, Frejd FY. Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications. FEBS Lett 2010; 584: 2670-80.
    • (2010) FEBS Lett , vol.584 , pp. 2670-2680
    • Lofblom, J.1    Feldwisch, J.2    Tolmachev, V.3    Carlsson, J.4    Stahl, S.5    Frejd, F.Y.6
  • 64
    • 43549101411 scopus 로고    scopus 로고
    • Alternative binding proteins: Affibody bindingproteins developed from a small three-helix bundle scaffold
    • Nygren PA. Alternative binding proteins: affibody bindingproteins developed from a small three-helix bundle scaffold. FEBS J 2008; 275: 2668-76.
    • (2008) FEBS J , vol.275 , pp. 2668-2676
    • Nygren, P.A.1
  • 65
    • 84855390257 scopus 로고    scopus 로고
    • Imaging of HumanEpidermal Growth Factor Receptor Type 2 Expression with 18F-Labeled Affibody Molecule ZHER2:2395 in a Mouse Model for Ovarian Cancer
    • Heskamp S, Laverman P, Rosik D, et al. Imaging of HumanEpidermal Growth Factor Receptor Type 2 Expression with 18F-Labeled Affibody Molecule ZHER2:2395 in a Mouse Model for Ovarian Cancer. J Nucl Med 2012; 53: 146-53.
    • (2012) J Nucl Med , vol.53 , pp. 146-153
    • Heskamp, S.1    Laverman, P.2    Rosik, D.3
  • 66
    • 79953766951 scopus 로고    scopus 로고
    • Optimal specific radioactivity of antiHER2 Affibody molecules enables discrimination between xenografts with high and low HER2 expression levels
    • Tolmachev V, Wallberg H, Sandstrom M, Hansson M, Wennborg A, Orlova A. Optimal specific radioactivity of antiHER2 Affibody molecules enables discrimination between xenografts with high and low HER2 expression levels. Eur J Nucl Med Mol Imaging 2011; 38: 531-9.
    • (2011) Eur J Nucl Med Mol Imaging , vol.38 , pp. 531-539
    • Tolmachev, V.1    Wallberg, H.2    Sandstrom, M.3    Hansson, M.4    Wennborg, A.5    Orlova, A.6
  • 67
    • 77953927395 scopus 로고    scopus 로고
    • Molecular imaging ofHER2-expressing malignant tumors in breast cancer patients using synthetic 111In-or 68Ga-labeled affibody molecules
    • Baum RP, Prasad V, Muller D, et al. Molecular imaging ofHER2-expressing malignant tumors in breast cancer patients using synthetic 111In-or 68Ga-labeled affibody molecules. J Nucl Med 2010; 51: 892-7.
    • (2010) J Nucl Med , vol.51 , pp. 892-897
    • Baum, R.P.1    Prasad, V.2    Muller, D.3
  • 68
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: Thecomplexity of targeted inhibitors
    • Hynes NE, Lane HA. ERBB receptors and cancer: thecomplexity of targeted inhibitors. Nat Rev Cancer 2005; 5: 341-54.
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 69
    • 4143150688 scopus 로고    scopus 로고
    • Immunohistochemicaland clinical characterization of the basal-like subtype of invasive breast carcinoma
    • Nielsen TO, Hsu FD, Jensen K, et al. Immunohistochemicaland clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 2004; 10: 5367-74.
    • (2004) Clin Cancer Res , vol.10 , pp. 5367-5374
    • Nielsen, T.O.1    Hsu, F.D.2    Jensen, K.3
  • 70
    • 0028330743 scopus 로고
    • The epidermal growth factor receptor as a prognostic marker: Results of 370 patients and review of 3009 patients
    • Fox SB, Smith K, Hollyer J, Greenall M, Hastrich D, Harris AL. The epidermal growth factor receptor as a prognostic marker: results of 370 patients and review of 3009 patients. Breast Cancer Res Treat 1994; 29: 41-9.
    • (1994) Breast Cancer Res Treat , vol.29 , pp. 41-49
    • Fox, S.B.1    Smith, K.2    Hollyer, J.3    Greenall, M.4    Hastrich, D.5    Harris, A.L.6
  • 71
    • 0026571910 scopus 로고
    • The clinicalsignificance of epidermal growth factor receptor (EGF-R) in human breast cancer: A review on 5232 patients
    • Klijn JG, Berns PM, Schmitz PI, Foekens JA. The clinicalsignificance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Endocr Rev 1992; 13: 3-17.
    • (1992) Endocr Rev , vol.13 , pp. 3-17
    • Klijn, J.G.1    Berns, P.M.2    Schmitz, P.I.3    Foekens, J.A.4
  • 72
    • 84864101306 scopus 로고    scopus 로고
    • TBCRC 001:Randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer
    • Carey LA, Rugo HS, Marcom PK, et al. TBCRC 001:randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer. J Clin Oncol 2012; 30: 2615-23.
    • (2012) J Clin Oncol , vol.30 , pp. 2615-2623
    • Carey, L.A.1    Rugo, H.S.2    Marcom, P.K.3
  • 73
    • 33749011681 scopus 로고    scopus 로고
    • A phase I study ofcetuximab/paclitaxel in patients with advanced-stage breast cancer
    • Modi S, D'Andrea G, Norton L, et al. A phase I study ofcetuximab/paclitaxel in patients with advanced-stage breast cancer. Clin Breast Cancer 2006; 7: 270-7.
    • (2006) Clin Breast Cancer , vol.7 , pp. 270-277
    • Modi, S.1    D'Andrea, G.2    Norton, L.3
  • 74
    • 0024425936 scopus 로고
    • Imaging of human tumor xenografts with an indium-111-labeled anti-epidermal growth factor receptor monoclonal antibody
    • Goldenberg A, Masui H, Divgi C, Kamrath H, Pentlow K, Mendelsohn J. Imaging of human tumor xenografts with an indium-111-labeled anti-epidermal growth factor receptor monoclonal antibody. J Natl Cancer Inst 1989; 81: 1616-25.
    • (1989) J Natl Cancer Inst , vol.81 , pp. 1616-1625
    • Goldenberg, A.1    Masui, H.2    Divgi, C.3    Kamrath, H.4    Pentlow, K.5    Mendelsohn, J.6
  • 75
    • 0028032152 scopus 로고
    • Indium-111-labeled anti-EGFr-425 scintigraphy in the detection of malignant gliomas
    • Dadparvar S, Krishna L, Miyamoto C, et al. Indium-111-labeled anti-EGFr-425 scintigraphy in the detection of malignant gliomas. Cancer 1994; 73: 884-9.
    • (1994) Cancer , vol.73 , pp. 884-889
    • Dadparvar, S.1    Krishna, L.2    Miyamoto, C.3
  • 76
    • 33748146468 scopus 로고    scopus 로고
    • Lack of usefulnessof epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer
    • Hebbar M, Wacrenier A, Desauw C, et al. Lack of usefulnessof epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer. Anticancer Drugs 2006; 17: 855-7.
    • (2006) Anticancer Drugs , vol.17 , pp. 855-857
    • Hebbar, M.1    Wacrenier, A.2    Desauw, C.3
  • 77
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab showsactivity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung KY, Shia J, Kemeny NE, et al. Cetuximab showsactivity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005; 23: 1803-10.
    • (2005) J Clin Oncol , vol.23 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3
  • 78
    • 58249105735 scopus 로고    scopus 로고
    • Disparity between in vivoEGFR expression and 89Zr-labeled cetuximab uptake assessed with PET
    • Aerts HJ, Dubois L, Perk L, et al. Disparity between in vivoEGFR expression and 89Zr-labeled cetuximab uptake assessed with PET. J Nucl Med 2009; 50: 123-31.
    • (2009) J Nucl Med , vol.50 , pp. 123-131
    • Aerts, H.J.1    Dubois, L.2    Perk, L.3
  • 80
    • 84859699116 scopus 로고    scopus 로고
    • Predictingcetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using 64Cu-labeled cetuximab positron emission tomography
    • Achmad A, Hanaoka H, Yoshioka H, et al. Predictingcetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using 64Cu-labeled cetuximab positron emission tomography. Cancer Sci 2012; 103: 600-5.
    • (2012) Cancer Sci , vol.103 , pp. 600-605
    • Achmad, A.1    Hanaoka, H.2    Yoshioka, H.3
  • 81
    • 68249160667 scopus 로고    scopus 로고
    • Strategies for molecular imaging ofepidermal growth factor receptor tyrosine kinase in cancer
    • Mishani E, Hagooly A. Strategies for molecular imaging ofepidermal growth factor receptor tyrosine kinase in cancer. J Nucl Med 2009; 50: 1199-202.
    • (2009) J Nucl Med , vol.50 , pp. 1199-1202
    • Mishani, E.1    Hagooly, A.2
  • 82
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lungcancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lungcancer: correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497-500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 83
    • 79952126083 scopus 로고    scopus 로고
    • Molecular imaging ofactive mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT
    • Yeh HH, Ogawa K, Balatoni J, et al. Molecular imaging ofactive mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT. Proc Natl Acad Sci U S A 2011; 108: 1603-8.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 1603-1608
    • Yeh, H.H.1    Ogawa, K.2    Balatoni, J.3
  • 84
    • 84856053461 scopus 로고    scopus 로고
    • PET imaging ofpatients with non-small cell lung cancer employing an EGF receptor targeting drug as tracer
    • Memon AA, Weber B, Winterdahl M, et al. PET imaging ofpatients with non-small cell lung cancer employing an EGF receptor targeting drug as tracer. Br J Cancer 2011; 105: 1850-5.
    • (2011) Br J Cancer , vol.105 , pp. 1850-1855
    • Memon, A.A.1    Weber, B.2    Winterdahl, M.3
  • 85
    • 79959914514 scopus 로고    scopus 로고
    • Erlotinibaccumulation in brain metastases from non-small cell lung cancer: Visualization by positron emission tomography in a patient harboring a mutation in the epidermal growth factor receptor
    • Weber B, Winterdahl M, Memon A, et al. Erlotinibaccumulation in brain metastases from non-small cell lung cancer: visualization by positron emission tomography in a patient harboring a mutation in the epidermal growth factor receptor. J Thorac Oncol 2011; 6: 1287-9.
    • (2011) J Thorac Oncol , vol.6 , pp. 1287-1289
    • Weber, B.1    Winterdahl, M.2    Memon, A.3
  • 86
    • 80053530037 scopus 로고    scopus 로고
    • Molecular imaging with 11C-PD153035 PET/CT predicts survival in non-small cell lung cancer treated with EGFR-TKI: A pilot study
    • Meng X, Loo BW, Jr., Ma L, Murphy JD, Sun X, Yu J. Molecular imaging with 11C-PD153035 PET/CT predicts survival in non-small cell lung cancer treated with EGFR-TKI: a pilot study. J Nucl Med 2011; 52: 1573-9.
    • (2011) J Nucl Med , vol.52 , pp. 1573-1579
    • Meng, X.1    Loo Jr., B.W.2    Ma, L.3    Murphy, J.D.4    Sun, X.5    Yu, J.6
  • 87
    • 73349120007 scopus 로고    scopus 로고
    • Independent review of E2100: A phase III trial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancer
    • Gray R, Bhattacharya S, Bowden C, Miller K, Comis RL. Independent review of E2100: a phase III trial of bevacizumab plus paclitaxel versus paclitaxel in women with metastatic breast cancer. J Clin Oncol 2009; 27: 4966-72.
    • (2009) J Clin Oncol , vol.27 , pp. 4966-4972
    • Gray, R.1    Bhattacharya, S.2    Bowden, C.3    Miller, K.4    Comis, R.L.5
  • 88
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plusbevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plusbevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357: 2666-76.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 89
    • 79960241809 scopus 로고    scopus 로고
    • Changing end points in breast-cancerdrug approval-the Avastin story
    • D'Agostino RB, Sr. Changing end points in breast-cancerdrug approval-the Avastin story. N Engl J Med 2011; 365: e2.
    • (2011) N Engl J Med , vol.365
    • D'Agostino Sr., R.B.1
  • 90
    • 84856291930 scopus 로고    scopus 로고
    • Neoadjuvantchemotherapy and bevacizumab for HER2-negative breast cancer
    • von Minckwitz G, Eidtmann H, Rezai M, et al. Neoadjuvantchemotherapy and bevacizumab for HER2-negative breast cancer. N Engl J Med 2012; 366: 299-309.
    • (2012) N Engl J Med , vol.366 , pp. 299-309
    • von Minckwitz, G.1    Eidtmann, H.2    Rezai, M.3
  • 91
    • 0028116528 scopus 로고
    • The fibronectinisoform containing the ED-B oncofetal domain: A marker of angiogenesis
    • Castellani P, Viale G, Dorcaratto A, et al. The fibronectinisoform containing the ED-B oncofetal domain: a marker of angiogenesis. Int J Cancer 1994; 59: 612-8.
    • (1994) Int J Cancer , vol.59 , pp. 612-618
    • Castellani, P.1    Viale, G.2    Dorcaratto, A.3
  • 92
    • 0032555478 scopus 로고    scopus 로고
    • Design and use of a phagedisplay library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel
    • Pini A, Viti F, Santucci A, et al. Design and use of a phagedisplay library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. J Biol Chem 1998; 273: 21769-76.
    • (1998) J Biol Chem , vol.273 , pp. 21769-31776
    • Pini, A.1    Viti, F.2    Santucci, A.3
  • 93
    • 0037314650 scopus 로고    scopus 로고
    • Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer
    • Santimaria M, Moscatelli G, Viale GL, et al. Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer. Clin Cancer Res 2003; 9: 571-9.
    • (2003) Clin Cancer Res , vol.9 , pp. 571-579
    • Santimaria, M.1    Moscatelli, G.2    Viale, G.L.3
  • 94
    • 18244376347 scopus 로고    scopus 로고
    • Noninvasivevisualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    • Haubner R, Weber WA, Beer AJ, et al. Noninvasivevisualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD. PLoS Med 2005; 2: e70.
    • (2005) PLoS Med , vol.2
    • Haubner, R.1    Weber, W.A.2    Beer, A.J.3
  • 95
    • 33750598987 scopus 로고    scopus 로고
    • Integrinreceptor imaging of breast cancer: A proof-of-concept study to evaluate 99mTc-NC100692
    • Bach-Gansmo T, Danielsson R, Saracco A, et al. Integrinreceptor imaging of breast cancer: a proof-of-concept study to evaluate 99mTc-NC100692. J Nucl Med 2006; 47: 1434-9.
    • (2006) J Nucl Med , vol.47 , pp. 1434-1439
    • Bach-Gansmo, T.1    Danielsson, R.2    Saracco, A.3
  • 96
    • 44849137859 scopus 로고    scopus 로고
    • Phase I trial of thepositron-emitting Arg-Gly-Asp (RGD) peptide radioligand 18F-AH111585 in breast cancer patients
    • Kenny LM, Coombes RC, Oulie I, et al. Phase I trial of thepositron-emitting Arg-Gly-Asp (RGD) peptide radioligand 18F-AH111585 in breast cancer patients. J Nucl Med 2008; 49: 879-86.
    • (2008) J Nucl Med , vol.49 , pp. 879-886
    • Kenny, L.M.1    Coombes, R.C.2    Oulie, I.3
  • 97
    • 84856209326 scopus 로고    scopus 로고
    • Differential diagnosis of solitarypulmonary nodules using mTc-3P-RGD scintigraphy
    • Ma Q, Ji B, Jia B, et al. Differential diagnosis of solitarypulmonary nodules using mTc-3P-RGD scintigraphy. Eur J Nucl Med Mol Imaging 2011; 38: 2145-52.
    • (2011) Eur J Nucl Med Mol Imaging , vol.38 , pp. 2145-2152
    • Ma, Q.1    Ji, B.2    Jia, B.3
  • 98
    • 84863116379 scopus 로고    scopus 로고
    • Whole-Body Distributionand Radiation Dosimetry of (68)Ga-NOTA-RGD, a Positron Emission Tomography Agent for Angiogenesis Imaging
    • Kim JH, Lee JS, Kang KW, et al. Whole-Body Distributionand Radiation Dosimetry of (68)Ga-NOTA-RGD, a Positron Emission Tomography Agent for Angiogenesis Imaging. Cancer Biother Radiopharm 2012; 27: 65-71.
    • (2012) Cancer Biother Radiopharm , vol.27 , pp. 65-71
    • Kim, J.H.1    Lee, J.S.2    Kang, K.W.3
  • 99
    • 25444503494 scopus 로고    scopus 로고
    • Biodistribution andpharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients
    • Beer AJ, Haubner R, Goebel M, et al. Biodistribution andpharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients. J Nucl Med 2005; 46: 1333-41.
    • (2005) J Nucl Med , vol.46 , pp. 1333-1341
    • Beer, A.J.1    Haubner, R.2    Goebel, M.3
  • 100
    • 33746032220 scopus 로고    scopus 로고
    • Positron emissiontomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man
    • Beer AJ, Haubner R, Sarbia M, et al. Positron emissiontomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man. Clin Cancer Res 2006; 12: 3942-9.
    • (2006) Clin Cancer Res , vol.12 , pp. 3942-3949
    • Beer, A.J.1    Haubner, R.2    Sarbia, M.3
  • 101
    • 33745548133 scopus 로고    scopus 로고
    • PET-based humandosimetry of 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression
    • Beer AJ, Haubner R, Wolf I, et al. PET-based humandosimetry of 18F-galacto-RGD, a new radiotracer for imaging alpha v beta3 expression. J Nucl Med 2006; 47: 763-9.
    • (2006) J Nucl Med , vol.47 , pp. 763-769
    • Beer, A.J.1    Haubner, R.2    Wolf, I.3
  • 102
    • 36749053493 scopus 로고    scopus 로고
    • 18F galacto-RGDpositron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck
    • Beer AJ, Grosu AL, Carlsen J, et al. 18F galacto-RGDpositron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res 2007; 13: 6610-6.
    • (2007) Clin Cancer Res , vol.13 , pp. 6610-6616
    • Beer, A.J.1    Grosu, A.L.2    Carlsen, J.3
  • 103
    • 38949212117 scopus 로고    scopus 로고
    • Patterns ofalphavbeta3 expression in primary and metastatic human breast cancer as shown by 18F-Galacto-RGD PET
    • Beer AJ, Niemeyer M, Carlsen J, et al. Patterns ofalphavbeta3 expression in primary and metastatic human breast cancer as shown by 18F-Galacto-RGD PET. J Nucl Med 2008; 49: 255-9.
    • (2008) J Nucl Med , vol.49 , pp. 255-259
    • Beer, A.J.1    Niemeyer, M.2    Carlsen, J.3
  • 104
    • 72449174017 scopus 로고    scopus 로고
    • Imaging of integrinalpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography
    • Schnell O, Krebs B, Carlsen J, et al. Imaging of integrinalpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography. Neuro Oncol 2009; 11: 861-70.
    • (2009) Neuro Oncol , vol.11 , pp. 861-870
    • Schnell, O.1    Krebs, B.2    Carlsen, J.3
  • 105
    • 0037278885 scopus 로고    scopus 로고
    • Integrin adhesion receptors in tumormetastasis
    • Felding-Habermann B. Integrin adhesion receptors in tumormetastasis. Clin Exp Metastasis 2003; 20: 203-13.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 203-213
    • Felding-Habermann, B.1
  • 107
    • 0031724191 scopus 로고    scopus 로고
    • Vascular integrinalpha(v)beta3: A new prognostic indicator in breast cancer
    • Gasparini G, Brooks PC, Biganzoli E, et al. Vascular integrinalpha(v)beta3: a new prognostic indicator in breast cancer. Clin Cancer Res 1998; 4: 2625-34.
    • (1998) Clin Cancer Res , vol.4 , pp. 2625-2634
    • Gasparini, G.1    Brooks, P.C.2    Biganzoli, E.3
  • 108
    • 75649102481 scopus 로고    scopus 로고
    • An open-label, multicenter, phase 2a study to assess the feasibility of imaging metastases in late-stage cancer patients with the alpha v beta 3-selective angiogenesis imaging agent 99mTc-NC100692
    • Axelsson R, Bach-Gansmo T, Castell-Conesa J, McParland BJ. An open-label, multicenter, phase 2a study to assess the feasibility of imaging metastases in late-stage cancer patients with the alpha v beta 3-selective angiogenesis imaging agent 99mTc-NC100692. Acta Radiol 2010; 51: 40-6.
    • (2010) Acta Radiol , vol.51 , pp. 40-46
    • Axelsson, R.1    Bach-Gansmo, T.2    Castell-Conesa, J.3    McParland, B.J.4
  • 109
    • 33846885522 scopus 로고    scopus 로고
    • PET of vascularendothelial growth factor receptor expression
    • Cai W, Chen K, Mohamedali KA, et al. PET of vascularendothelial growth factor receptor expression. J Nucl Med 2006; 47: 2048-56.
    • (2006) J Nucl Med , vol.47 , pp. 2048-2056
    • Cai, W.1    Chen, K.2    Mohamedali, K.A.3
  • 110
    • 0042510474 scopus 로고    scopus 로고
    • Imaginggastrointestinal tumours using vascular endothelial growth factor-165 (VEGF165) receptor scintigraphy
    • Li S, Peck-Radosavljevic M, Kienast O, et al. Imaginggastrointestinal tumours using vascular endothelial growth factor-165 (VEGF165) receptor scintigraphy. Ann Oncol 2003; 14: 1274-7.
    • (2003) Ann Oncol , vol.14 , pp. 1274-1277
    • Li, S.1    Peck-Radosavljevic, M.2    Kienast, O.3
  • 111
    • 42149169958 scopus 로고    scopus 로고
    • Specificimaging of VEGF-A expression with radiolabeled anti-VEGF monoclonal antibody
    • Stollman TH, Scheer MG, Leenders WP, et al. Specificimaging of VEGF-A expression with radiolabeled anti-VEGF monoclonal antibody. Int J Cancer 2008; 122: 2310-4.
    • (2008) Int J Cancer , vol.122 , pp. 2310-2314
    • Stollman, T.H.1    Scheer, M.G.2    Leenders, W.P.3
  • 112
    • 34547736456 scopus 로고    scopus 로고
    • In vivoVEGF imaging with radiolabeled bevacizumab in a human ovarian tumor xenograft
    • Nagengast WB, de Vries EG, Hospers GA, et al. In vivoVEGF imaging with radiolabeled bevacizumab in a human ovarian tumor xenograft. J Nucl Med 2007; 48: 1313-9.
    • (2007) J Nucl Med , vol.48 , pp. 1313-1319
    • Nagengast, W.B.1    de Vries, E.G.2    Hospers, G.A.3
  • 113
    • 49549090861 scopus 로고    scopus 로고
    • Imaging livermetastases of colorectal cancer patients with radiolabelled bevacizumab: Lack of correlation with VEGF-A expression
    • Scheer MG, Stollman TH, Boerman OC, et al. Imaging livermetastases of colorectal cancer patients with radiolabelled bevacizumab: Lack of correlation with VEGF-A expression. Eur J Cancer 2008; 44: 1835-40.
    • (2008) Eur J Cancer , vol.44 , pp. 1835-1840
    • Scheer, M.G.1    Stollman, T.H.2    Boerman, O.C.3
  • 114
    • 79851500109 scopus 로고    scopus 로고
    • 111In-bevacizumab imaging of renal cell cancer and evaluation of neoadjuvant treatment with the vascular endothelial growth factor receptor inhibitor sorafenib
    • Desar IM, Stillebroer AB, Oosterwijk E, et al. 111In-bevacizumab imaging of renal cell cancer and evaluation of neoadjuvant treatment with the vascular endothelial growth factor receptor inhibitor sorafenib. J Nucl Med 2010; 51: 1707-15.
    • (2010) J Nucl Med , vol.51 , pp. 1707-1715
    • Desar, I.M.1    Stillebroer, A.B.2    Oosterwijk, E.3
  • 115
    • 79958812484 scopus 로고    scopus 로고
    • VEGF-SPECT with 111In-bevacizumab in stage III/IV melanoma patients
    • Nagengast WB, Hooge MN, van Straten EM, et al. VEGF-SPECT with 111In-bevacizumab in stage III/IV melanoma patients. Eur J Cancer 2011; 47: 1595-602.
    • (2011) Eur J Cancer , vol.47 , pp. 1595-1602
    • Nagengast, W.B.1    Hooge, M.N.2    van Straten, E.M.3
  • 116
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGFsystem in cancer growth and metastasis: Overview and recent insights
    • Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGFsystem in cancer growth and metastasis: overview and recent insights. Endocr Rev 2007; 28: 20-47.
    • (2007) Endocr Rev , vol.28 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    Leroith, D.3    Brodt, P.4
  • 117
  • 118
    • 0028233617 scopus 로고
    • The prognostic value ofinsulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients
    • Railo MJ, von SK, Pekonen F. The prognostic value ofinsulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients. Eur J Cancer 1994; 30A: 307-11.
    • (1994) Eur J Cancer , vol.30 A , pp. 307-311
    • Railo, M.J.1    Von, S.K.2    Pekonen, F.3
  • 119
    • 62449205665 scopus 로고    scopus 로고
    • Chemoresistant colorectalcancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
    • Dallas NA, Xia L, Fan F, et al. Chemoresistant colorectalcancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res 2009; 69: 1951-7.
    • (2009) Cancer Res , vol.69 , pp. 1951-1957
    • Dallas, N.A.1    Xia, L.2    Fan, F.3
  • 120
    • 66149092327 scopus 로고    scopus 로고
    • Hyperactivation ofthe insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells
    • Eckstein N, Servan K, Hildebrandt B, et al. Hyperactivation ofthe insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res 2009; 69: 2996-3003.
    • (2009) Cancer Res , vol.69 , pp. 2996-3003
    • Eckstein, N.1    Servan, K.2    Hildebrandt, B.3
  • 121
    • 0034724886 scopus 로고    scopus 로고
    • Insulin receptor substrate-1expression is regulated by estrogen in the MCF-7 human breast cancer cell line
    • Molloy CA, May FE, Westley BR. Insulin receptor substrate-1expression is regulated by estrogen in the MCF-7 human breast cancer cell line. J Biol Chem 2000; 275: 12565-71.
    • (2000) J Biol Chem , vol.275 , pp. 12565-12571
    • Molloy, C.A.1    May, F.E.2    Westley, B.R.3
  • 122
    • 34249049000 scopus 로고    scopus 로고
    • Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib
    • Morgillo F, Kim WY, Kim ES, Ciardiello F, Hong WK, Lee HY. Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res 2007; 13: 2795-803.
    • (2007) Clin Cancer Res , vol.13 , pp. 2795-2803
    • Morgillo, F.1    Kim, W.Y.2    Kim, E.S.3    Ciardiello, F.4    Hong, W.K.5    Lee, H.Y.6
  • 123
    • 69449097339 scopus 로고    scopus 로고
    • Emerging role of insulin-like growthfactor receptor inhibitors in oncology: Early clinical trial results and future directions
    • Gualberto A, Pollak M. Emerging role of insulin-like growthfactor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene 2009; 28: 3009-21.
    • (2009) Oncogene , vol.28 , pp. 3009-3021
    • Gualberto, A.1    Pollak, M.2
  • 124
    • 54249157471 scopus 로고    scopus 로고
    • Addiction to elevated insulin-likegrowth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody
    • Cao L, Yu Y, Darko I, et al. Addiction to elevated insulin-likegrowth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody. Cancer Res 2008; 68: 8039-48.
    • (2008) Cancer Res , vol.68 , pp. 8039-8048
    • Cao, L.1    Yu, Y.2    Darko, I.3
  • 125
    • 68849128275 scopus 로고    scopus 로고
    • Molecular predictors ofresponse to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer
    • Zha J, O'Brien C, Savage H, et al. Molecular predictors ofresponse to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer. Mol Cancer Ther 2009; 8: 2110-21.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2110-2121
    • Zha, J.1    O'Brien, C.2    Savage, H.3
  • 126
    • 48249128676 scopus 로고    scopus 로고
    • Thelevel of insulin growth factor-1 receptor expression is directly correlated with the tumor uptake of (111)In-IGF-1(E3R) in vivo and the clonogenic survival of breast cancer cells exposed in vitro to trastuzumab (Herceptin)
    • Cornelissen B, McLarty K, Kersemans V, Reilly RM. Thelevel of insulin growth factor-1 receptor expression is directly correlated with the tumor uptake of (111)In-IGF-1(E3R) in vivo and the clonogenic survival of breast cancer cells exposed in vitro to trastuzumab (Herceptin). Nucl Med Biol 2008; 35: 645-53.
    • (2008) Nucl Med Biol , vol.35 , pp. 645-653
    • Cornelissen, B.1    McLarty, K.2    Kersemans, V.3    Reilly, R.M.4
  • 127
    • 0030612291 scopus 로고    scopus 로고
    • Biodistribution of 125I-labeled des(1-3) insulin-like growth factor I in tumor-bearing nude mice and its in vitro catabolism
    • Sun BF, Kobayashi H, Le N, et al. Biodistribution of 125I-labeled des(1-3) insulin-like growth factor I in tumor-bearing nude mice and its in vitro catabolism. Cancer Res 1997; 57: 2754-9.
    • (1997) Cancer Res , vol.57 , pp. 2754-2759
    • Sun, B.F.1    Kobayashi, H.2    Le, N.3
  • 128
    • 0033973809 scopus 로고    scopus 로고
    • Effects of insulinlikegrowth factor binding proteins on insulinlike growth factor-I biodistribution in tumor-bearing nude mice
    • Sun BF, Kobayashi H, Le N, et al. Effects of insulinlikegrowth factor binding proteins on insulinlike growth factor-I biodistribution in tumor-bearing nude mice. J Nucl Med 2000; 41: 318-26.
    • (2000) J Nucl Med , vol.41 , pp. 318-326
    • Sun, B.F.1    Kobayashi, H.2    Le, N.3
  • 129
    • 79851482773 scopus 로고    scopus 로고
    • ImmunoSPECT and immunoPET of IGF-1R expression with the radiolabeled antibody R1507 in a triple-negative breast cancer model
    • Heskamp S, van Laarhoven HW, Molkenboer-Kuenen JD, et al. ImmunoSPECT and immunoPET of IGF-1R expression with the radiolabeled antibody R1507 in a triple-negative breast cancer model. J Nucl Med 2010; 51: 1565-72.
    • (2010) J Nucl Med , vol.51 , pp. 1565-1572
    • Heskamp, S.1    van Laarhoven, H.W.2    Molkenboer-Kuenen, J.D.3
  • 131
    • 65249122512 scopus 로고    scopus 로고
    • Novel therapeutic inhibitors of the c-Met signaling pathway in cancer
    • Eder JP, Vande Woude GF, Boerner SA, LoRusso PM. Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin Cancer Res 2009; 15: 2207-14.
    • (2009) Clin Cancer Res , vol.15 , pp. 2207-2214
    • Eder, J.P.1    Vande, W.G.F.2    Boerner, S.A.3    Lorusso, P.M.4
  • 132
    • 0033404948 scopus 로고    scopus 로고
    • Met expression is associatedwith poor outcome in patients with axillary lymph node negative breast carcinoma
    • Camp RL, Rimm EB, Rimm DL. Met expression is associatedwith poor outcome in patients with axillary lymph node negative breast carcinoma. Cancer 1999; 86: 2259-65.
    • (1999) Cancer , vol.86 , pp. 2259-2265
    • Camp, R.L.1    Rimm, E.B.2    Rimm, D.L.3
  • 133
  • 134
    • 16844363750 scopus 로고    scopus 로고
    • Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients
    • Lee WY, Chen HH, Chow NH, Su WC, Lin PW, Guo HR. Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients. Clin Cancer Res 2005; 11: 2222-8.
    • (2005) Clin Cancer Res , vol.11 , pp. 2222-2228
    • Lee, W.Y.1    Chen, H.H.2    Chow, N.H.3    Su, W.C.4    Lin, P.W.5    Guo, H.R.6
  • 135
    • 40449113978 scopus 로고    scopus 로고
    • Metreceptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells
    • Shattuck DL, Miller JK, Carraway KL, 3rd, Sweeney C. Metreceptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells. Cancer Res 2008; 68: 1471-7.
    • (2008) Cancer Res , vol.68 , pp. 1471-1477
    • Shattuck, D.L.1    Miller, J.K.2    Carraway III, K.L.3    Sweeney, C.4
  • 137
    • 12444339058 scopus 로고    scopus 로고
    • Radioimmunoscintigraphyof human met-expressing tumor xenografts using met3, a new monoclonal antibody
    • Hay RV, Cao B, Skinner RS, et al. Radioimmunoscintigraphyof human met-expressing tumor xenografts using met3, a new monoclonal antibody. Clin Cancer Res 2003; 9: 3839S-44S.
    • (2003) Clin Cancer Res , vol.9
    • Hay, R.V.1    Cao, B.2    Skinner, R.S.3
  • 138
    • 52449133141 scopus 로고    scopus 로고
    • Quantitative PET imaging of Met-expressing human cancer xenografts with 89Zr-labelled monoclonal antibody DN30
    • Perk LR, Stigter-van Walsum M, Visser GW, et al. Quantitative PET imaging of Met-expressing human cancer xenografts with 89Zr-labelled monoclonal antibody DN30. Eur J Nucl Med Mol Imaging 2008; 35: 1857-67.
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , pp. 1857-1867
    • Perk, L.R.1    Stigter-Van, W.M.2    Visser, G.W.3
  • 139
    • 74849102049 scopus 로고    scopus 로고
    • In vivo positron emissiontomography (PET) imaging of mesenchymal-epithelial transition (MET) receptor
    • Wu C, Tang Z, Fan W, et al. In vivo positron emissiontomography (PET) imaging of mesenchymal-epithelial transition (MET) receptor. J Med Chem 2010; 53: 139-46.
    • (2010) J Med Chem , vol.53 , pp. 139-146
    • Wu, C.1    Tang, Z.2    Fan, W.3
  • 141
    • 77950216941 scopus 로고    scopus 로고
    • An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation
    • Schoeberl B, Faber AC, Li D, et al. An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation. Cancer Res 2010; 70: 2485-94.
    • (2010) Cancer Res , vol.70 , pp. 2485-2494
    • Schoeberl, B.1    Faber, A.C.2    Li, D.3
  • 142
    • 18544370238 scopus 로고    scopus 로고
    • Anti-HER-3MAbs inhibit HER-3-mediated signaling in breast cancer cell lines resistant to anti-HER-2 antibodies
    • van der Horst EH, Murgia M, Treder M, Ullrich A. Anti-HER-3MAbs inhibit HER-3-mediated signaling in breast cancer cell lines resistant to anti-HER-2 antibodies. Int J Cancer 2005; 115: 519-27.
    • (2005) Int J Cancer , vol.115 , pp. 519-527
    • van der Horst, E.H.1    Murgia, M.2    Treder, M.3    Ullrich, A.4
  • 143
    • 76749136371 scopus 로고    scopus 로고
    • AZD8931, anequipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: A unique agent for simultaneous ERBB receptor blockade in cancer
    • Hickinson DM, Klinowska T, Speake G, et al. AZD8931, anequipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res 2010; 16: 1159-69.
    • (2010) Clin Cancer Res , vol.16 , pp. 1159-1169
    • Hickinson, D.M.1    Klinowska, T.2    Speake, G.3
  • 144
    • 11244316378 scopus 로고    scopus 로고
    • Early phase I data on an irreversible pan-erbinhibitor: CI-1033. What did we learn?
    • Dewji MR. Early phase I data on an irreversible pan-erbinhibitor: CI-1033. What did we learn? J Chemother 2004; 16 Suppl 4: 44-8.
    • (2004) J Chemother , vol.16 , Issue.SUPPL. 4 , pp. 44-48
    • Dewji, M.R.1
  • 145
    • 34547450199 scopus 로고    scopus 로고
    • The HER4 cytoplasmicdomain, but not its C terminus, inhibits mammary cell proliferation
    • Feng SM, Sartor CI, Hunter D, et al. The HER4 cytoplasmicdomain, but not its C terminus, inhibits mammary cell proliferation. Mol Endocrinol 2007; 21: 1861-76.
    • (2007) Mol Endocrinol , vol.21 , pp. 1861-1876
    • Feng, S.M.1    Sartor, C.I.2    Hunter, D.3
  • 146
    • 44149098849 scopus 로고    scopus 로고
    • Cytogenetic analysis ofHER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients
    • Sassen A, Rochon J, Wild P, et al. Cytogenetic analysis ofHER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients. Breast Cancer Res 2008; 10: R2.
    • (2008) Breast Cancer Res , vol.10
    • Sassen, A.1    Rochon, J.2    Wild, P.3
  • 147
    • 77249164620 scopus 로고    scopus 로고
    • Immunohistochemicalexpression of HER1, HER3, and HER4 in HER2-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy
    • Yonemori K, Tsuta K, Shimizu C, et al. Immunohistochemicalexpression of HER1, HER3, and HER4 in HER2-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy. J Surg Oncol 2010; 101: 222-7.
    • (2010) J Surg Oncol , vol.101 , pp. 222-227
    • Yonemori, K.1    Tsuta, K.2    Shimizu, C.3
  • 148
    • 0038575385 scopus 로고    scopus 로고
    • Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer
    • Witton CJ, Reeves JR, Going JJ, Cooke TG, Bartlett JM. Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer. J Pathol 2003; 200: 290-7.
    • (2003) J Pathol , vol.200 , pp. 290-297
    • Witton, C.J.1    Reeves, J.R.2    Going, J.J.3    Cooke, T.G.4    Bartlett, J.M.5
  • 149
    • 77449116470 scopus 로고    scopus 로고
    • Presenceof HER4 associates with increased sensitivity to Herceptin in patients with metastatic breast cancer
    • Sassen A, Diermeier-Daucher S, Sieben M, et al. Presenceof HER4 associates with increased sensitivity to Herceptin in patients with metastatic breast cancer. Breast Cancer Res 2009; 11: R50.
    • (2009) Breast Cancer Res , vol.11
    • Sassen, A.1    Diermeier-Daucher, S.2    Sieben, M.3
  • 150
    • 79960824315 scopus 로고    scopus 로고
    • Basal-like molecular subtypeand HER4 up-regulation and response to neoadjuvant chemotherapy in breast cancer
    • Stickeler E, Pils D, Klar M, et al. Basal-like molecular subtypeand HER4 up-regulation and response to neoadjuvant chemotherapy in breast cancer. Oncol Rep 2011; 26: 1037-45.
    • (2011) Oncol Rep , vol.26 , pp. 1037-1045
    • Stickeler, E.1    Pils, D.2    Klar, M.3
  • 151
    • 79952686672 scopus 로고    scopus 로고
    • Combining phageand staphylococcal surface display for generation of ErbB3-specific Affibody molecules
    • Kronqvist N, Malm M, Gostring L, et al. Combining phageand staphylococcal surface display for generation of ErbB3-specific Affibody molecules. Protein Eng Des Sel 2011; 24: 385-96.
    • (2011) Protein Eng Des Sel , vol.24 , pp. 385-396
    • Kronqvist, N.1    Malm, M.2    Gostring, L.3
  • 152
    • 0030845817 scopus 로고    scopus 로고
    • Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: Definition of phenotypic groups
    • Courjal F, Cuny M, Simony-Lafontaine J, et al. Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups. Cancer Res 1997; 57: 4360-7.
    • (1997) Cancer Res , vol.57 , pp. 4360-4367
    • Courjal, F.1    Cuny, M.2    Simony-Lafontaine, J.3
  • 153
    • 77950866696 scopus 로고    scopus 로고
    • Integrativemolecular profiling of triple negative breast cancers identifiesamplicon drivers and potential therapeutic targets
    • Turner N, Lambros MB, Horlings HM, et al. Integrativemolecular profiling of triple negative breast cancers identifiesamplicon drivers and potential therapeutic targets. Oncogene 2010; 29: 2013-23.
    • (2010) Oncogene , vol.29 , pp. 2013-2023
    • Turner, N.1    Lambros, M.B.2    Horlings, H.M.3
  • 154
    • 80051685673 scopus 로고    scopus 로고
    • FGFRSignaling Promotes the Growth of Triple-Negative and Basal-Like Breast Cancer Cell Lines Both In Vitro and In Vivo
    • Sharpe R, Pearson A, Herrera-Abreu MT, et al. FGFRSignaling Promotes the Growth of Triple-Negative and Basal-Like Breast Cancer Cell Lines Both In Vitro and In Vivo. Clin Cancer Res 2011; 17: 5275-86.
    • (2011) Clin Cancer Res , vol.17 , pp. 5275-5286
    • Sharpe, R.1    Pearson, A.2    Herrera-Abreu, M.T.3
  • 155
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: A key receptor in the crosstalkbetween tumor cells and their microenvironment
    • Burger JA, Kipps TJ. CXCR4: a key receptor in the crosstalkbetween tumor cells and their microenvironment. Blood 2006; 107: 1761-7.
    • (2006) Blood , vol.107 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 156
    • 66149145860 scopus 로고    scopus 로고
    • Chemokinereceptors in advanced breast cancer: Differential expression in metastatic disease sites with diagnostic and therapeutic implications
    • Cabioglu N, Sahin AA, Morandi P, et al. Chemokinereceptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications. Ann Oncol 2009; 20: 1013-9.
    • (2009) Ann Oncol , vol.20 , pp. 1013-1019
    • Cabioglu, N.1    Sahin, A.A.2    Morandi, P.3
  • 157
    • 33745334601 scopus 로고    scopus 로고
    • The role ofCXCR4 receptor expression in breast cancer: A large tissue microarray study
    • Salvucci O, Bouchard A, Baccarelli A, et al. The role ofCXCR4 receptor expression in breast cancer: a large tissue microarray study. Breast Cancer Res Treat 2006; 97: 275-83.
    • (2006) Breast Cancer Res Treat , vol.97 , pp. 275-283
    • Salvucci, O.1    Bouchard, A.2    Baccarelli, A.3
  • 158
    • 7944223780 scopus 로고    scopus 로고
    • Upregulation of CXCR4 isessential for HER2-mediated tumor metastasis
    • Li YM, Pan Y, Wei Y, et al. Upregulation of CXCR4 isessential for HER2-mediated tumor metastasis. Cancer Cell 2004; 6: 459-69.
    • (2004) Cancer Cell , vol.6 , pp. 459-469
    • Li, Y.M.1    Pan, Y.2    Wei, Y.3
  • 159
    • 33646125873 scopus 로고    scopus 로고
    • CXCR4 and VEGFexpression in the primary site and the metastatic site of human osteosarcoma: Analysis within a group of patients, all of whom developed lung metastasis
    • Oda Y, Yamamoto H, Tamiya S, et al. CXCR4 and VEGFexpression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. Mod Pathol 2006; 19: 738-45.
    • (2006) Mod Pathol , vol.19 , pp. 738-745
    • Oda, Y.1    Yamamoto, H.2    Tamiya, S.3
  • 160
    • 23044472971 scopus 로고    scopus 로고
    • CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation
    • Cabioglu N, Summy J, Miller C, et al. CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation. Cancer Res 2005; 65: 6493-7.
    • (2005) Cancer Res , vol.65 , pp. 6493-6497
    • Cabioglu, N.1    Summy, J.2    Miller, C.3
  • 161
    • 24944553762 scopus 로고    scopus 로고
    • Stromal cell-derivedfactor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation
    • Porcile C, Bajetto A, Barbieri F, et al. Stromal cell-derivedfactor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation. Exp Cell Res 2005; 308: 241-53.
    • (2005) Exp Cell Res , vol.308 , pp. 241-253
    • Porcile, C.1    Bajetto, A.2    Barbieri, F.3
  • 162
    • 78751560129 scopus 로고    scopus 로고
    • Cytokine receptorCXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer
    • Rhodes LV, Short SP, Neel NF, et al. Cytokine receptorCXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res 2011; 71: 603-13.
    • (2011) Cancer Res , vol.71 , pp. 603-613
    • Rhodes, L.V.1    Short, S.P.2    Neel, N.F.3
  • 163
    • 3042616145 scopus 로고    scopus 로고
    • Inhibition of breast cancermetastasis by selective synthetic polypeptide against CXCR4
    • Liang Z, Wu T, Lou H, et al. Inhibition of breast cancermetastasis by selective synthetic polypeptide against CXCR4. Cancer Res 2004; 64: 4302-8.
    • (2004) Cancer Res , vol.64 , pp. 4302-4308
    • Liang, Z.1    Wu, T.2    Lou, H.3
  • 164
    • 80455129861 scopus 로고    scopus 로고
    • CXCR4-based imagingagents
    • Woodard LE, Nimmagadda S. CXCR4-based imagingagents. J Nucl Med 2011; 52: 1665-9.
    • (2011) J Nucl Med , vol.52 , pp. 1665-1669
    • Woodard, L.E.1    Nimmagadda, S.2
  • 165
    • 77952792463 scopus 로고    scopus 로고
    • Molecular imaging of CXCR4receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography
    • Nimmagadda S, Pullambhatla M, Stone K, Green G, Bhujwalla ZM, Pomper MG. Molecular imaging of CXCR4receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography. Cancer Res 2010; 70: 3935-44.
    • (2010) Cancer Res , vol.70 , pp. 3935-3944
    • Nimmagadda, S.1    Pullambhatla, M.2    Stone, K.3    Green, G.4    Bhujwalla, Z.M.5    Pomper, M.G.6
  • 166
    • 77956138084 scopus 로고    scopus 로고
    • A pretherapy biodistribution and dosimetry study of indium-111-radiolabeled trastuzumab in patients with human epidermal growth factor receptor 2-overexpressing breast cancer
    • Wong JY, Raubitschek A, Yamauchi D, et al. A pretherapy biodistribution and dosimetry study of indium-111-radiolabeled trastuzumab in patients with human epidermal growth factor receptor 2-overexpressing breast cancer. Cancer Biother Radiopharm 2010; 25: 387-94.
    • (2010) Cancer Biother Radiopharm , vol.25 , pp. 387-394
    • Wong, J.Y.1    Raubitschek, A.2    Yamauchi, D.3


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