The distinctive nature of HER2-positive breast cancers

New England Journal of Medicine

Volumn 353, Issue 16, 2005, Pages 1652-1654

  Burstein, Harold J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; STEROID RECEPTOR; TAMOXIFEN; TRASTUZUMAB; VASCULOTROPIN;

BREAST CANCER; CANCER CHEMOTHERAPY; CARCINOGENESIS; CELL CULTURE; CELL PROLIFERATION; CLINICAL TRIAL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; GENE AMPLIFICATION; GENE OVEREXPRESSION; HUMAN; LIGAND BINDING; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; SHORT SURVEY;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, ERBB-2; HUMANS; RECEPTOR, ERBB-2;

EID: 26844457534     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMp058197     Document Type: Short Survey

References (4)

1. Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2001;2:127-37.
2. Cho HS, Mason K, Ramyar KX, et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003;421:756-60.
3. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-82.
4. Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-52.