A critical role of CD29 and CD49f in mediating metastasis for cancer-initiating cells isolated from a Brca1-associated mouse model of breast cancer

Oncogene

Volumn 33, Issue 47, 2014, Pages 5477-5482

  Vassilopoulos, A ^a,b   Chisholm, C ^a   Lahusen, T ^a   Zheng, H ^a   Deng, C X ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

cancer metastasis; CD29; CD49f; CSCs; EMT

Indexed keywords

ALPHA6 INTEGRIN; BRCA1 PROTEIN; CD24 ANTIGEN; CD24A PROTEIN, MOUSE; LEPTIN RECEPTOR; LEPTIN RECEPTOR, MOUSE; TUMOR MARKER;

ANIMAL; CANCER STEM CELL; CELL CULTURE; CELL MOTION; DISEASE MODEL; EPITHELIAL MESENCHYMAL TRANSITION; EXPERIMENTAL MAMMARY NEOPLASM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; NUDE MOUSE; PATHOLOGY;

ANIMALS; ANTIGENS, CD24; BRCA1 PROTEIN; CELL MOVEMENT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; INTEGRIN ALPHA6; MAMMARY NEOPLASMS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE, NUDE; MUTATION; NEOPLASTIC STEM CELLS; RECEPTORS, LEPTIN; TUMOR MARKERS, BIOLOGICAL;

EID: 84889074151     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.516     Document Type: Article

References (49)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics 2010CA Cancer J Clin 2010; 60: 277-300
2. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70
3. Bernards R, Weinberg RA. A progression puzzle. Nature 2002; 418: 823
4. Wright JA, Egan SE, Greenberg AH. Genetic regulation of metastatic progression. Anticancer Res 1990; 10: 1247-1255
5. van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, et al. A geneexpression signature as a predictor of survival in breast cancer. N Engl J Med 2002; 347: 1999-2009
6. Nicolson GL. Paracrine/autocrine growth mechanisms in tumor metastasis. Oncol Res 1992; 4: 389-399
7. Husemann Y, Geigl JB, Schubert F, Musiani P, Meyer M, Burghart E, et al. Systemic spread is an early step in breast cancer. Cancer Cell 2008; 13: 58-68
8. Podsypanina K, Du YC, Jechlinger M, Beverly LJ, Hambardzumyan D, Varmus H. Seeding and propagation of untransformed mouse mammary cells in the lung. Science 2008; 321: 1841-1844
9. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003; 100: 3983-3988
10. Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004; 64: 7011-7021
11. Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, et al. Identification of pancreatic cancer stem cells. Cancer Res 2007; 67: 1030-1037
12. O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007; 445: 106-110
13. Baccelli I, Trumpp A. The evolving concept of cancer and metastasis stem cells. J Cell Biol 2012; 198: 281-293
14. Song LL, Miele L. Cancer stem cells-An old idea that's new again: implications for the diagnosis and treatment of breast cancer. Expert Opin Biol Ther 2007; 7: 431-438
15. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelialmesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-715
16. Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, et al. The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 2007; 356: 217-226
17. Liu H, Patel MR, Prescher JA, Patsialou A, Qian D, Lin J, et al. Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A 2010; 107: 18115-18120
18. Dave B, Mittal V, Tan NM, Chang JC. Epithelial-mesenchymal transition, cancer stem cells and treatment resistance. Breast Cancer Res 2012; 14: 202
19. Foroni C, Broggini M, Generali D, Damia G. Epithelial-mesenchymal transition and breast cancer: role, molecular mechanisms and clinical impact. Cancer Treat Rev 2012; 38: 689-697
20. Hale JS, Li M, Lathia JD. The malignant social network: cell-cell adhesion and communication in cancer stem cells. Cell Adh Migr 2012; 6: 346-355
21. Lathia JD, Heddleston JM, Venere M, Rich JN. Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell Stem Cell 2011; 8: 482-485
22. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994; 266: 66-71
23. Alberg AJ, Helzlsouer KJ. Epidemiology, prevention, and early detection of breast cancer. Curr Opin Oncol 1997; 9: 505-511
24. Zhang J, Powell SN. The role of the BRCA1 tumor suppressor in DNA doublestrand break repair. Mol Cancer Res 2005; 3: 531-539
25. Brody LC, Biesecker BB. Breast cancer susceptibility genes. BRCA1 and BRCA2. Medicine (Baltimore) 1998; 77: 208-226
26. Eccles DM, Pichert G. Familial non-BRCA1/BRCA2-Associated breast cancer. Lancet Oncol 2005; 6: 705-711
27. Hu Y. BRCA1, hormone, and tissue-specific tumor suppression. Int J Biol Sci 2009; 5: 20-27
28. Deng CX. Tumor formation in Brca1 conditional mutant mice. Environ Mol Mutagen 2002; 39: 171-177
29. Deng CX. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response, and cancer evolution. Nucleic Acids Res 2006; 34: 1416-1426
30. Diaz-Cruz ES, Cabrera MC, Nakles R, Rutstein BH, Furth PA. BRCA1 deficient mouse models to study pathogenesis and therapy of triple negative breast cancer. Breast Dis 2010; 32: 85-97
31. Roy R, Chun J, Powell SN. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer 2012; 12: 68-78
32. Venkitaraman AR. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2002; 108: 171-182
33. Drost RM, Jonkers J. Preclinical mouse models for BRCA1-Associated breast cancer. Br J Cancer 2009; 101: 1651-1657
34. Deng CX, Wang RH. Roles of BRCA1 in DNA damage repair: a link between development and cancer. Hum Mol Genet 2003; 12: R113-R123
35. Deng CX, Brodie SG. Roles of BRCA1 and its interacting proteins. Bioessays 2000; 22: 728-737
36. Dine J, Deng CX. Mouse models of BRCA1 and their application to breast cancer research. Cancer Metast Rev 2012; 32: 25-37
37. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, et al. Generation of a functional mammary gland from a single stem cell. Nature 2006; 439: 84-88
38. Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, et al. Purification and unique properties of mammary epithelial stem cells. Nature 2006; 439: 993-997
39. Vassilopoulos A, Wang RH, Petrovas C, Ambrozak D, Koup R, Deng CX. Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells. Int J Biol Sci 2008; 4: 133-142
40. van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002; 415: 530-536
41. Gritsenko PG, Ilina O, Friedl P. Interstitial guidance of cancer invasion. J Pathol 2012; 226: 185-199
42. Lanza DG, Ma J, Guest I, Uk-Lim C, Glinskii A, Glinsky G, et al. Tumor-derived mesenchymal stem cells and orthotopic site increase the tumor initiation potential of putative mouse mammary cancer stem cells derived from MMTVPyMT mice. Tumour Biol 2012; 33: 1997-2005
43. Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D, et al. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res 2008; 68: 4674-4682
44. Lahlou H, Muller WJ. Beta1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer. Breast Cancer Res 2011; 13: 229
45. Ali HR, Dawson SJ, Blows FM, Provenzano E, Pharoah PD, Caldas C. Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance. Breast Cancer Res 2011; 13: R118
46. Lee EC, Lotz MM, Steele Jr. GD, Mercurio AM. The integrin alpha 6 beta 4 is a laminin receptor. J Cell Biol 1992; 117: 671-678
47. Nielsen PK, Yamada Y. Identification of cell-binding sites on the Laminin alpha 5 N-Terminal domain by site-directed mutagenesis. J Biol Chem 2001; 276: 10906-10912
48. Niessen CM, Cremona O, Daams H, Ferraresi S, Sonnenberg A, Marchisio PC. Expression of the integrin alpha 6 beta 4 in peripheral nerves: localization in Schwann and perineural cells and different variants of the beta 4 subunit. J Cell Sci 1994; 107(Pt 2): 543-552
49. Sonnenberg A, Gehlsen KR, Aumailley M, Timpl R. Isolation of alpha 6 beta 1 integrins from platelets and adherent cells by affinity chromatography on mouse laminin fragment E8 and human laminin pepsin fragment. Exp Cell Res 1991; 197: 234-244