메뉴 건너뛰기




Volumn 65, Issue 12, 2013, Pages 3084-3095

The peroxisome proliferator-activated receptor γ agonist pioglitazone preserves bone microarchitecture in experimental arthritis by reducing the interleukin-17-dependent osteoclastogenic pathway

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PIOGLITAZONE;

EID: 84889058863     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.38130     Document Type: Article
Times cited : (14)

References (54)
  • 1
    • 0035883897 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • Lee DM, Weinblatt ME,. Rheumatoid arthritis. Lancet 2001; 358: 903-11.
    • (2001) Lancet , vol.358 , pp. 903-911
    • Lee, D.M.1    Weinblatt, M.E.2
  • 2
    • 0028305241 scopus 로고
    • Generalised bone loss in patients with early rheumatoid arthritis
    • Gough AK, Lilley J, Eyre S, Holder RL, Emery P,. Generalised bone loss in patients with early rheumatoid arthritis. Lancet 1994; 344: 23-7.
    • (1994) Lancet , vol.344 , pp. 23-27
    • Gough, A.K.1    Lilley, J.2    Eyre, S.3    Holder, R.L.4    Emery, P.5
  • 3
    • 44049104564 scopus 로고    scopus 로고
    • H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
    • H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. Nat Immunol 2008; 9: 641-9.
    • (2008) Nat Immunol , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 4
    • 13444256307 scopus 로고    scopus 로고
    • The role of T-cell interleukin-17 in conducting destructive arthritis: Lessons from animal models
    • Lubberts E, Koenders MI, van den Berg WB,. The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 2005; 7: 29-37.
    • (2005) Arthritis Res Ther , vol.7 , pp. 29-37
    • Lubberts, E.1    Koenders, M.I.2    Van Den Berg, W.B.3
  • 5
    • 77949571314 scopus 로고    scopus 로고
    • Wnt pathway and IL-17: Novel regulators of joint remodeling in rheumatic diseases: Looking beyond the RANK-RANKL-OPG axis
    • Daoussis D, Andonopoulos AP, Liossis SN,. Wnt pathway and IL-17: novel regulators of joint remodeling in rheumatic diseases: looking beyond the RANK-RANKL-OPG axis. Semin Arthritis Rheum 2008; 39: 369-83.
    • (2008) Semin Arthritis Rheum , vol.39 , pp. 369-383
    • Daoussis, D.1    Andonopoulos, A.P.2    Liossis, S.N.3
  • 6
    • 42749086111 scopus 로고    scopus 로고
    • The dynamic interplay between osteoclasts and the immune system
    • Nakashima T, Takayanagi H,. The dynamic interplay between osteoclasts and the immune system. Arch Biochem Biophys 2008; 473: 166-71.
    • (2008) Arch Biochem Biophys , vol.473 , pp. 166-171
    • Nakashima, T.1    Takayanagi, H.2
  • 7
    • 0006132932 scopus 로고    scopus 로고
    • Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
    • Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc Natl Acad Sci U S A 1997; 94: 4318-23.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4318-4323
    • Kliewer, S.A.1    Sundseth, S.S.2    Jones, S.A.3    Brown, P.J.4    Wisely, G.B.5    Koble, C.S.6
  • 9
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK,. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 1998; 391: 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 10
    • 36049034344 scopus 로고    scopus 로고
    • Anti-inflammatory actions of PPAR ligands: New insights on cellular and molecular mechanisms
    • Straus DS, Glass CK,. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol 2007; 28: 551-8.
    • (2007) Trends Immunol , vol.28 , pp. 551-558
    • Straus, D.S.1    Glass, C.K.2
  • 11
    • 0037135036 scopus 로고    scopus 로고
    • PPARγ ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice
    • Shiojiri T, Wada K, Nakajima A, Katayama K, Shibuya A, Kudo C, et al. PPARγ ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice. Eur J Pharmacol 2002; 448: 231-8.
    • (2002) Eur J Pharmacol , vol.448 , pp. 231-238
    • Shiojiri, T.1    Wada, K.2    Nakajima, A.3    Katayama, K.4    Shibuya, A.5    Kudo, C.6
  • 12
    • 10744224449 scopus 로고    scopus 로고
    • Reduction in the evolution of murine type II collagen- induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator- activated receptor γ
    • Cuzzocrea S, Mazzon E, Dugo L, Patel NS, Serraino I, Di Paola R, et al. Reduction in the evolution of murine type II collagen- induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor γ. Arthritis Rheum 2003; 48: 3544-56.
    • (2003) Arthritis Rheum , vol.48 , pp. 3544-3556
    • Cuzzocrea, S.1    Mazzon, E.2    Dugo, L.3    Patel, N.S.4    Serraino, I.5    Di Paola, R.6
  • 13
    • 39049167582 scopus 로고    scopus 로고
    • Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis
    • Koufany M, Moulin D, Bianchi A, Muresan M, Sebillaud S, Netter P, et al. Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis. Arthritis Res Ther 2008; 10: R6.
    • (2008) Arthritis Res Ther , vol.10
    • Koufany, M.1    Moulin, D.2    Bianchi, A.3    Muresan, M.4    Sebillaud, S.5    Netter, P.6
  • 14
    • 79958160488 scopus 로고    scopus 로고
    • Effect of peroxisome proliferator-activated receptor γ agonist (pioglitazone) and methotrexate on disease activity in rheumatoid arthritis (experimental and clinical study)
    • Shahin D, Toraby EE, Abdel-Malek H, Boshra V, Elsamanoudy AZ, Shaheen D,. Effect of peroxisome proliferator-activated receptor γ agonist (pioglitazone) and methotrexate on disease activity in rheumatoid arthritis (experimental and clinical study). Clin Med Insights Arthritis Musculoskelet Disord 2011; 4: 1-10.
    • (2011) Clin Med Insights Arthritis Musculoskelet Disord , vol.4 , pp. 1-10
    • Shahin, D.1    Toraby, E.E.2    Abdel-Malek, H.3    Boshra, V.4    Elsamanoudy, A.Z.5    Shaheen, D.6
  • 15
    • 67651089911 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands as potential therapeutic agents to treat arthritis
    • Giaginis C, Giagini A, Theocharis S,. Peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands as potential therapeutic agents to treat arthritis. Pharmacol Res 2009; 60: 160-9.
    • (2009) Pharmacol Res , vol.60 , pp. 160-169
    • Giaginis, C.1    Giagini, A.2    Theocharis, S.3
  • 16
    • 33745714392 scopus 로고    scopus 로고
    • PPARs and other nuclear receptors in inflammation
    • Rizzo G, Fiorucci S,. PPARs and other nuclear receptors in inflammation. Curr Opin Pharmacol 2006; 6: 421-7.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 421-427
    • Rizzo, G.1    Fiorucci, S.2
  • 17
    • 20444440328 scopus 로고    scopus 로고
    • Inhibition of NF-κB signaling by fenofibrate, a peroxisome proliferator-activated receptor-α ligand, presents a therapeutic strategy for rheumatoid arthritis
    • Okamoto H, Iwamoto T, Kotake S, Momohara S, Yamanaka H, Kamatani N,. Inhibition of NF-κB signaling by fenofibrate, a peroxisome proliferator-activated receptor-α ligand, presents a therapeutic strategy for rheumatoid arthritis. Clin Exp Rheumatol 2005; 23: 323-30.
    • (2005) Clin Exp Rheumatol , vol.23 , pp. 323-330
    • Okamoto, H.1    Iwamoto, T.2    Kotake, S.3    Momohara, S.4    Yamanaka, H.5    Kamatani, N.6
  • 20
    • 65549111189 scopus 로고    scopus 로고
    • Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone
    • Syversen U, Stunes AK, Gustafsson BI, Obrant KJ, Nordsletten L, Berge R, et al. Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone. BMC Endocr Disord 2009; 9: 10.
    • (2009) BMC Endocr Disord , vol.9 , pp. 10
    • Syversen, U.1    Stunes, A.K.2    Gustafsson, B.I.3    Obrant, K.J.4    Nordsletten, L.5    Berge, R.6
  • 21
    • 2142652189 scopus 로고    scopus 로고
    • PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    • Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N, et al. PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004; 113: 846-55.
    • (2004) J Clin Invest , vol.113 , pp. 846-855
    • Akune, T.1    Ohba, S.2    Kamekura, S.3    Yamaguchi, M.4    Chung, U.I.5    Kubota, N.6
  • 22
    • 36849034568 scopus 로고    scopus 로고
    • PPAR-γ regulates osteoclastogenesis in mice
    • Wan Y, Chong LW, Evans RM,. PPAR-γ regulates osteoclastogenesis in mice. Nat Med 2007; 13: 1496-503.
    • (2007) Nat Med , vol.13 , pp. 1496-1503
    • Wan, Y.1    Chong, L.W.2    Evans, R.M.3
  • 23
    • 34548391628 scopus 로고    scopus 로고
    • THR0921, a novel peroxisome proliferator-activated receptor γ agonist, reduces the severity of collagen-induced arthritis
    • Tomita T, Kakiuchi Y, Tsao PS,. THR0921, a novel peroxisome proliferator-activated receptor γ agonist, reduces the severity of collagen-induced arthritis. Arthritis Res Ther 2006; 8: R7.
    • (2006) Arthritis Res Ther , vol.8
    • Tomita, T.1    Kakiuchi, Y.2    Tsao, P.S.3
  • 24
    • 80053251651 scopus 로고    scopus 로고
    • JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis
    • Denninger K, Rasmussen S, Larsen JM, Orskov C, Seier Poulsen S, Sorensen P, et al. JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis. Am J Pathol 2011; 179: 1884-93.
    • (2011) Am J Pathol , vol.179 , pp. 1884-1893
    • Denninger, K.1    Rasmussen, S.2    Larsen, J.M.3    Orskov, C.4    Seier Poulsen, S.5    Sorensen, P.6
  • 25
    • 48749108520 scopus 로고    scopus 로고
    • Effects of risedronate in a rat model of osteopenia due to orchidectomy and disuse: Densitometric, histomorphometric and microtomographic studies
    • Libouban H, Blouin S, Moreau MF, Basle MF, Audran M, Chappard D,. Effects of risedronate in a rat model of osteopenia due to orchidectomy and disuse: densitometric, histomorphometric and microtomographic studies. Micron 2008; 39: 998-1007.
    • (2008) Micron , vol.39 , pp. 998-1007
    • Libouban, H.1    Blouin, S.2    Moreau, M.F.3    Basle, M.F.4    Audran, M.5    Chappard, D.6
  • 27
    • 37749034527 scopus 로고    scopus 로고
    • Skeletal consequences of thiazolidinedione therapy
    • Grey A,. Skeletal consequences of thiazolidinedione therapy. Osteoporos Int 2008; 19: 129-37.
    • (2008) Osteoporos Int , vol.19 , pp. 129-137
    • Grey, A.1
  • 28
    • 33847629923 scopus 로고    scopus 로고
    • Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes - A meta-analysis
    • Vestergaard P,. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes-a meta-analysis. Osteoporos Int 2007; 18: 427-44.
    • (2007) Osteoporos Int , vol.18 , pp. 427-444
    • Vestergaard, P.1
  • 29
    • 0029847076 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells
    • Gimble JM, Robinson CE, Wu X, Kelly KA, Rodriguez BR, Kliewer SA, et al. Peroxisome proliferator-activated receptor-γ activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol 1996; 50: 1087-94.
    • (1996) Mol Pharmacol , vol.50 , pp. 1087-1094
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3    Kelly, K.A.4    Rodriguez, B.R.5    Kliewer, S.A.6
  • 31
    • 0034640397 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-γ pathway inhibits osteoclast differentiation
    • Mbalaviele G, Abu-Amer Y, Meng A, Jaiswal R, Beck S, Pittenger MF, et al. Activation of peroxisome proliferator-activated receptor-γ pathway inhibits osteoclast differentiation. J Biol Chem 2000; 275: 14388-93.
    • (2000) J Biol Chem , vol.275 , pp. 14388-14393
    • Mbalaviele, G.1    Abu-Amer, Y.2    Meng, A.3    Jaiswal, R.4    Beck, S.5    Pittenger, M.F.6
  • 32
    • 0029861141 scopus 로고    scopus 로고
    • Effects of indomethacin administration on bone turnover and bone mass in adjuvant-induced arthritis in rats
    • Aota S, Nakamura T, Suzuki K, Tanaka Y, Okazaki Y, Segawa Y, et al. Effects of indomethacin administration on bone turnover and bone mass in adjuvant-induced arthritis in rats. Calcif Tissue Int 1996; 59: 385-91.
    • (1996) Calcif Tissue Int , vol.59 , pp. 385-391
    • Aota, S.1    Nakamura, T.2    Suzuki, K.3    Tanaka, Y.4    Okazaki, Y.5    Segawa, Y.6
  • 33
    • 0027452006 scopus 로고
    • Application of computer-based histomorphometry to the quantitative analysis of methylprednisolone-treated adjuvant arthritis in rats
    • Jee WS, Li XJ, Ke HZ, Li M, Smith RJ, Dunn CJ,. Application of computer-based histomorphometry to the quantitative analysis of methylprednisolone-treated adjuvant arthritis in rats. Bone Miner 1993; 22: 221-47.
    • (1993) Bone Miner , vol.22 , pp. 221-247
    • Jee, W.S.1    Li, X.J.2    Ke, H.Z.3    Li, M.4    Smith, R.J.5    Dunn, C.J.6
  • 35
    • 50949097032 scopus 로고    scopus 로고
    • Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats
    • Noguchi M, Kimoto A, Sasamata M, Miyata K,. Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats. J Bone Miner Metab 2008; 26: 461-8.
    • (2008) J Bone Miner Metab , vol.26 , pp. 461-468
    • Noguchi, M.1    Kimoto, A.2    Sasamata, M.3    Miyata, K.4
  • 38
    • 42749083246 scopus 로고    scopus 로고
    • Functions of RANKL/RANK/OPG in bone modeling and remodeling
    • Boyce BF, Xing L,. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 2008; 473: 139-46.
    • (2008) Arch Biochem Biophys , vol.473 , pp. 139-146
    • Boyce, B.F.1    Xing, L.2
  • 39
    • 0037371262 scopus 로고    scopus 로고
    • IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-κB ligand/osteoprotegerin balance
    • Lubberts E, van den Bersselaar L, Oppers-Walgreen B, Schwarzenberger P, Coenen-de Roo CJ, Kolls JK, et al. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-κB ligand/osteoprotegerin balance. J Immunol 2003; 170: 2655-62.
    • (2003) J Immunol , vol.170 , pp. 2655-2662
    • Lubberts, E.1    Van Den Bersselaar, L.2    Oppers-Walgreen, B.3    Schwarzenberger, P.4    Coenen-De Roo, C.J.5    Kolls, J.K.6
  • 40
    • 0036068297 scopus 로고    scopus 로고
    • Kinetics of bone protection by recombinant osteoprotegerin therapy in Lewis rats with adjuvant arthritis
    • Campagnuolo G, Bolon B, Feige U,. Kinetics of bone protection by recombinant osteoprotegerin therapy in Lewis rats with adjuvant arthritis. Arthritis Rheum 2002; 46: 1926-36.
    • (2002) Arthritis Rheum , vol.46 , pp. 1926-1936
    • Campagnuolo, G.1    Bolon, B.2    Feige, U.3
  • 42
    • 24644434101 scopus 로고    scopus 로고
    • RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis
    • Stolina M, Adamu S, Ominsky M, Dwyer D, Asuncion F, Geng Z, et al. RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis. J Bone Miner Res 2005; 20: 1756-65.
    • (2005) J Bone Miner Res , vol.20 , pp. 1756-1765
    • Stolina, M.1    Adamu, S.2    Ominsky, M.3    Dwyer, D.4    Asuncion, F.5    Geng, Z.6
  • 43
    • 33750351338 scopus 로고    scopus 로고
    • Potential new targets in arthritis therapy: Interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis
    • Koenders MI, Joosten LA, van den Berg WB,. Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Ann Rheum Dis 2006; 65 Suppl 3: iii29-33.
    • (2006) Ann Rheum Dis , vol.65 , Issue.SUPPL. 3
    • Koenders, M.I.1    Joosten, L.A.2    Van Den Berg, W.B.3
  • 44
    • 0033134608 scopus 로고    scopus 로고
    • IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    • Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999; 103: 1345-52.
    • (1999) J Clin Invest , vol.103 , pp. 1345-1352
    • Kotake, S.1    Udagawa, N.2    Takahashi, N.3    Matsuzaki, K.4    Itoh, K.5    Ishiyama, S.6
  • 45
    • 80052015098 scopus 로고    scopus 로고
    • IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates
    • Moran EM, Heydrich R, Ng CT, Saber TP, McCormick J, Sieper J, et al. IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates. PloS One 2011; 6: e24048.
    • (2011) PloS One , vol.6
    • Moran, E.M.1    Heydrich, R.2    Ng, C.T.3    Saber, T.P.4    McCormick, J.5    Sieper, J.6
  • 47
    • 58149398613 scopus 로고    scopus 로고
    • A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis
    • Eyles JL, Hickey MJ, Norman MU, Croker BA, Roberts AW, Drake SF, et al. A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis. Blood 2008; 112: 5193-201.
    • (2008) Blood , vol.112 , pp. 5193-5201
    • Eyles, J.L.1    Hickey, M.J.2    Norman, M.U.3    Croker, B.A.4    Roberts, A.W.5    Drake, S.F.6
  • 48
    • 15944422109 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor γ ligand rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency
    • Lytle C, Tod TJ, Vo KT, Lee JW, Atkinson RD, Straus DS,. The peroxisome proliferator-activated receptor γ ligand rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency. Inflamm Bowel Dis 2005; 11: 231-43.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 231-243
    • Lytle, C.1    Tod, T.J.2    Vo, K.T.3    Lee, J.W.4    Atkinson, R.D.5    Straus, D.S.6
  • 49
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006; 126: 1121-33.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 50
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ
    • Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. Immunity 2008; 28: 29-39.
    • (2008) Immunity , vol.28 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3    Akimzhanov, A.4    Kang, H.S.5    Chung, Y.6
  • 52
    • 70350459594 scopus 로고    scopus 로고
    • The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
    • Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, et al. The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med 2009; 206: 2079-89.
    • (2009) J Exp Med , vol.206 , pp. 2079-2089
    • Klotz, L.1    Burgdorf, S.2    Dani, I.3    Saijo, K.4    Flossdorf, J.5    Hucke, S.6
  • 53
    • 84861694481 scopus 로고    scopus 로고
    • A novel isoform of the orphan receptor RORγt suppresses IL-17 production in human T cells
    • Rauen T, Juang YT, Hedrich CM, Kis-Toth K, Tsokos GC,. A novel isoform of the orphan receptor RORγt suppresses IL-17 production in human T cells. Genes Immun 2012; 13: 346-50.
    • (2012) Genes Immun , vol.13 , pp. 346-350
    • Rauen, T.1    Juang, Y.T.2    Hedrich, C.M.3    Kis-Toth, K.4    Tsokos, G.C.5
  • 54
    • 39549091298 scopus 로고    scopus 로고
    • Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation
    • Chen Z, Laurence A, O'Shea JJ,. Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol 2007; 19: 400-8.
    • (2007) Semin Immunol , vol.19 , pp. 400-408
    • Chen, Z.1    Laurence, A.2    O'Shea, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.