Structure of the toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence

Journal of Biological Chemistry

Volumn 288, Issue 48, 2013, Pages 34968-34980

  Lim, Daniel ^a   Gold, Daniel A ^a   Julien, Lindsay ^a   Rosowski, Emily E ^a   Niedelman, Wendy ^a   Yaffe, Michael B ^a   Saeij, Jeroen P J ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ANALYSIS; HUMAN POPULATION; INTRACELLULAR PARASITES; INVASION PROCESS; MOLECULAR FUNCTION; MUTATIONAL ANALYSIS; SER/THR PROTEIN KINASE; TOXOPLASMA GONDII;

LIGANDS;

ENZYMES;

PROTEIN ROP18; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CELL INVASION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ANALYSIS; ENZYME RELEASE; ENZYME STRUCTURE; FEMALE; GENETIC ANALYSIS; HOST CELL; IN VITRO STUDY; LIGAND BINDING; MOUSE; NONHUMAN; PARASITE VIRULENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; TOXOPLASMA GONDII; TOXOPLASMOSIS;

EID: 84889001769     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.523266     Document Type: Article

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