Pro-apoptotic effect of rice bran Inositol Hexaphosphate (IP6) on HT-29 colorectal cancer cells

International Journal of Molecular Sciences

Volumn 14, Issue 12, 2013, Pages 23545-23558

  Shafie, Nurul Husna ^a   Esa, Norhaizan Mohd ^a   Ithnin, Hairuszah ^a   Saad, Norazalina ^a   Pandurangan, Ashok Kumar ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Apoptosis; Colorectal cancer; Inositol hexaphosphate; Rice bran

Indexed keywords

CASPASE 3; CASPASE 8; PHYTIC ACID; PROTEIN BAX; PROTEIN BCL XL; ANTINEOPLASTIC AGENT; MESSENGER RNA; PROTEIN BCL X;

APOPTOSIS; ARTICLE; COLORECTAL CARCINOMA; COLORIMETRY; CONTROLLED STUDY; DOWN REGULATION; EXTRACTION; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RICE BRAN; SPECTROPHOTOMETRY; UPREGULATION; WESTERN BLOTTING; CHEMISTRY; DRUG EFFECTS; GENETICS; HT 29 CELL LINE; ISOLATION AND PURIFICATION; METABOLISM; RICE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 3; CASPASE 8; DOWN-REGULATION; HT29 CELLS; HUMANS; ORYZA SATIVA; PHYTIC ACID; RNA, MESSENGER; UP-REGULATION;

EID: 84888881066     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141223545     Document Type: Article

References (38)

1. Ferlay, J.; Shin, H.R.; Bray, F.; Forman, D.; Mathers, C.; Parkin, D.M. Estimates of worldwide burden of cancer in 2008: Globocan 2008. Int. J. Cancer 2010, 127, 2893-2917.
2. Siegel, R.; Naishadham, D.; Jemal, A. Cancer statistics, 2012. CA: Cancer J. Clin. 2012, 62, 10-29.
3. Hahn, W.C.; Weinberg, R.A. Mechanisms of disease: Rules for making human tumor cells. N. Engl. J. Med. 2002, 347, 1593-1603.
4. Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
5. Rieger, P.T. The biology of cancer genetics. Semin. Oncol. Nurs. 2004, 20, 145-154.
6. Larson, S.C.; Giovannucci, E.; Bergkvist, L.; Wolk, A. Whole grain consumption and risk of colorectal cancer: A population-based cohort of 60,000 women. Br. J. Cancer 2005, 92, 1803-1807.
7. Ferguson, L.R.; Harris, P.J. Studies on the role of specific dietary fibres in protection against colorectal cancer. Mutat. Res. 1996, 350, 173-184.
8. Kasim, A.B.; Edwards, H.M., Jr. The analysis for inositol phosphate forms in feed ingredients. J. Sci. Food Agric. 1998, 76, 1-9.
9. Jariwalla, R.J. Rice bran products: Phytonutrients with potential applications in preventive and clinical medicine. Drugs Exp. Clin. Res. 2001, 27, 17-26.
10. Adams, J.M.; Cory, S. Bcl-2-regulated apoptosis: Mechanism and therapeutic potential. Curr. Opin. Immunol. 2007, 19, 488-496.
11. Martinou, J.-C.; Youle, R.J. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev. Cell 2011, 21, 92-101.
12. Youle, R.J.; Strasser, A. The BCL-2 protein family: Opposing activities that mediate cell death. Nat. Dev. Mol. Cell Biol. 2008, 9, 47-59.
13. Chipuk, J.E.; Green, D.R. How do Bcl-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol. 2011, 18, 157-164.
14. Newmeyer, D.D.; Ferguson-Miller, S. Mitochondria: Releasing power for life and unleash in the machineries of death. Cell 2003, 112, 481-490.
15. Gerl, R.; Vaux, D.L. Apoptosis in the development and treatment of cancer. Carcinogenesis 2005, 26, 263-270.
16. Liu, X.; Yue, P.; Zhou, Z.; Khuri, F.R.; Sun, S.Y. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J. Natl. Cancer Inst. 2004, 96, 1769-1780.
17. Ullah, A.; Shamsuddin, A.M. Dose-dependent inhibition of intestinal cancer by inositol hexaphosphate in F344 rats. Carcinogenesis 1990, 11, 2219-2222.
18. Vucenik, I.; Sakamoto, K.; Bansal, M.; Shamsuddin, A.M. Inhibition of mammary carcinogenesis by inositol hexaphosphate (phytic acid). A pilot study. Cancer Lett. 1993, 75, 95-102.
19. Vucenik, I.; Yang, G.Y.; Shamsuddin, A.M. Inositol hexaphosphate and inositol inhibit DMBA-induced rat mammary cancer. Carcinogenesis 1995, 16, 1055-1058.
20. Norazalina, S.; Norhaizan, M.E.; Hairuszah, I.; Norashareena, M.S. Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats. Exp. Toxicol. Pathol. 2010, 62, 259-268.
21. Nurul-Husna, S.; Norhaizan, M.E.; Hairuszah, I.; Abdah, M.A.; Norazalina, S.; Norsharina, I. Rice bran phytic acid (IP6) induces growth inhibition, cell cycle arrest and apoptosis on human colorectal adenocarcinoma cells. J. Med. Plants Res. 2010, 4, 2283-2289.
22. Norazalina, S.; Norhaizan, M.E.; Hairuszah, I.; Sabariah, A.R.; Nurul Husna, S.; Norsharina, S. Antiproliferation and apoptosis induction of phytic acid in hepatocellular carcinoma (HEPG2) cell lines. Afr. J. Biotechnol. 2011, 10, 16646-16653.
23. Hengartner, M.O. The biochemistry of apoptosis. Nature 2000, 407, 770-776.
24. Bouchier-Hayes, L.; Lartigue, L.; Newmeyer, D.D. Mitochondria: Pharmacological manipulation of cell death. J. Clin. Invest. 2005, 115, 2640-2647.
25. Bernardi, P.; Krauskopf, A.; Basso, E.; Petronilli, V.; Blachly-Dyson, E.; di Lisa, F.; Forte, M.A. The mitochondrial permeability transition from in vitro artifact to disease target. FEBS Lett. 2006, 273, 2077-2099.
26. Bernardi, P.; von Stockum, S. The permeability t ransit i on pore as a Ca(2+) r elease channel: New answers to an old question. Cell Calcium 2012, 52, 22-27.
27. Degterev, A.; Boyce, M.; Yuan, J. A decade of caspases. Oncogene 2003, 22, 8543-8567.
28. Sharma, G.; Singh, R.P.; Agarwal, R. Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells. Int. J. Oncol. 2003, 23, 1413-1418.
29. Schroterova, L.; Haskova, P.; Rudolf, E.; Cervinka, M. Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma. Oncol. Rep. 2010, 23, 787-793.
30. Salvesen, G.S. Caspases: Opening the boxes and interpreting the arrows. Cell Death Differ. 2002, 9, 3-5.
31. Li, P.; Nijhawan, D.; Wang, X. Mitochondrial activation of apoptosis. Cell 2004, 116, 57-59.
32. Katunuma, N.; Matsui, A.; Le, Q.T.; Utsumi, K.; Salvesen, G.; Ohashi, A. Novel procaspase-3 activating cascade mediated by lysoapoptases and its biological significances in apoptosis. Adv. Enzyme Regul. 2001, 41, 237-250.
33. Pandurangan, A.K.; Dharmalingam, P.; Ananda Sadagopan, S.K.; Ramar, M.; Munusamy, A.; Ganapasam, S. Luteolin induces growth arrest in colon cancer cells through involvement of Wnt/β-catenin/GSK-3β. J. Environ. Pathol. Toxicol. Oncol. 2013, 32, 131-139.
34. Czerski, L.; Nuñez, G. Apoptosome formation and Caspase activation: Is it different in the heart? J. Mol. Cell. Cardiol. 2004, 37, 643-652.
35. Shafie, N.H.; Mohd Esa, N.; Ithnin, H.; Md Akim, A.; Saad, N.; Pandurangan, A.K. Preventive Inositol Hexaphosphate (IP6) extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways. BioMed Res. Int. 2013, 2013, 1-10.
36. Saad, N.; Esa, N.M.; Ithnin, H.; Shafie, N.H. Optimization of optimum condition for phytic acid extraction from rice bran. Afr. J. Plant Sci. 2011, 5, 168-175.
37. Pandurangan, A.K.; Dharmalngam, P.; Anandasadagopan, S.K.; Ganapasam, S. Effect of luteolin on the levels of glycoproteins during azoxymethane-induced colon carcinogenesis in mice. Asian Pac. J. Cancer Prev. 2012, 13, 1569-1573.
38. Karthikeyan, K.; Bai B.R.; Devaraj, S.N. Cardioprotective effect of grape seed proanthocyanidins on isoproterenol-induced myocardial injury in rats. Int. J. Cardiol. 2007, 115, 326-333.