Antiproliferation and apoptosis induction of phytic acid in hepatocellular carcinoma (HEPG2) cell lines

African Journal of Biotechnology

Volumn 10, Issue 73, 2011, Pages 16646-16653

  Norazalina, Saad ^a   Norhaizan, Mohd Esa ^a   Hairuszah, Ithnin ^a   Sabariah, Abdul Rahman ^a   Husna, Shafie Nurul ^a   Norsharina, Ismail ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Anticancer; Apoptosis; Cell cycle; Phytic acid; Rice bran

Indexed keywords

LIPOCORTIN 5; PHYTIC ACID; PROPIDIUM IODIDE;

ADJUVANT CHEMOTHERAPY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CANCER PREVENTION; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LIVER CELL CARCINOMA; RICE BRAN;

EID: 81855218977     PISSN: 16845315     EISSN: None     Source Type: Journal    
DOI: 10.5897/AJB11.699     Document Type: Article

References (27)

1. Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R (2003). Inositol hexaphosphate inhibits constitutive activation of NF-kappa B in androgen-independent human prostate carcinoma DU145 cells. Anticancer Res. 23: 3855-3861.
2. Camire AL, Clydesdale FM (1982). Analysis of phytic acid in foods by HPLC. J. Food Sci. 47: 575-578.
3. Diallo JS, Betton B, Parent N (2008). Enhanced killing of androgenindependent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors. Br. J. Cancer 99: 1613-22.
4. El-Sherbiny Y, Cox MC, Ismail ZA, Shamsuddin AM, Vucenik I (2001). G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6). Anticancer Res. 19: 3717-3722.
5. Fruhbeck G, Alonso R, Marzo F, Santidrian SA (1995). Modified method for the indirect quantitative analysis of phytate in foodstuff. Analytical Biochem. 225: 206-212.
6. Hu W, Wells JH, Shin TS, Godber JS (1996). Comparison of isopropanol and hexane for extraction of vitamin E and oryzanols from stabilized rice bran. J. Am. Oil Chemists' Soc. 12: 1653-673.
7. Jariwalla RJ (2001). Rice-bran products: phytonutrients with potential applications in preventive and clinical medicine. Drugs Exp. Clin. Res 27: 17-26.
8. Karmakar S, Banik NL, Ray SK (2007). Molecular mechanism of inositol hexaphosphate-mediated apoptosis in human malignant glioblastoma T98G cells. Neurochem. Res. 32: 2094-2104.
9. Matejuk A, Shamsuddin AK (2010). IP6 in Cancer Therapy: Past, Present and Future. Curr. Cancer Ther. Rev., (6): p. 1.
10. McFadden DW, Riggs DR, Jackson BJ, Cunningham C (2008). Cornderived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms. Oncol. Rep. 19: 563-566.
11. Nagata E, Luo HR, Saiardi A, Bae BI, Suzuki N, Snyder SH (2005). Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol. Chem. 280: 1634-1640.
12. Norazalina S, Norhaizan ME, Hairuszah I, Norashareena MS (2010). Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats. Exp. Toxicol. Pathol. 62: 259-268.
13. Nurul Husna S, Norhaizan ME, Hairuszah I, Abdah MA, Norazalina S, Norsharina I (2010). Rice bran phytic acid (IP6) induces growth inhibition, cell cycle arrest and apoptosis on human colorectal adenocarcinoma cells. J. Medicinal Plants Res. 21: 2283-2289.
14. Ramezanzadeh FM, Rao RM, Windhauser M, Prinyawiwat-kul RT, Marshall WE (1999). Prevention of hydrolytic rancidity in bran during storage. J. Agric. Food Chem. 47: 3050-3052.
15. Reddy BS, Hirose Y, Cohen LA, Simi B, Cooma I, Rao CV (2000). Preventive potential of wheat bran fractions against experimental colon carcinogenesis: implications for human colon cancer prevention. Cancer Res 60: 4792-4797.
16. 3H]-Phytic acid (Inositol hexaphosphate) is absorbed and distributed to various tissues in rats. J. Nutr. 123: 713-720.
17. Somasundar P, Riggs DR, Jackson BJ (2005). Inositol Hexaphosphate (IP6): A Novel Treatment for Pancreatic Cancer. J. Surgical Res. 126: 199-203.
18. Shamsuddin AM (1995). Inositol phosphates have novel anticancer function. J. Nutr. 125: 725S-32S.
19. Singh RP, Agarwal C, Agarwal R (2003). Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis, 24(3): 555-563.
20. Shamsuddin AM, Yang GY, Vucenik I (1996). Novel anti-cancer functions of phytic acid growth inhibition and differentiation of human mammary cancer cell lines in vitro. Anticancer Res. 16: 3287-3292.
21. Sun GP, Wang H, Shen YX, Xu SY (2004). Inhibitory effects of phenol on the proliferation on four tumor cell lines. Anhui Yiyao, 8: 85-87.
22. Vucenik I, Zheng ZS, Shamsuddin AM (1998). IP6 in treatment of liver cancer. IL Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted in nude mice. Anticancer Res. 18: 4091-4096.
23. Vucenik I, Ramakrishna G, Tantivejkul K, Anderaon IM, RamIjak D (2005). Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation. Breast Cancer Res. Treat. 91: 35-45.
24. Vucenik I, Passaniti A, Vitolo MI, Tantivejkul K, Egglrton P, Shamsuddin AM (2004). Anti-angiogenic activity of inositol hexaphosphate (IP6). Carcinogenesis, 25: 2115-23.
25. WAF1 mRNA in human colon cancer HT-29 cells treated with inositol hexaphosphate. Acta Biochimica Polinica, 53(2): 349-356.
26. Xu SP, Sun GP, Shen YX, Wei W, Peng WR, Wang H (2007). Antiproliferation and apoptosis induction of paeonol in HepG2 cells. World J. Gastroenterol. 14; 13(2): 250-256.
27. Zhou L, Chan WK, Xu N, Xiao K, Luo H, Luo KQ, Chang DC (2008). Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest. Life Sci. 183(11-12): 394-403.