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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6593-6597

Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

(9) Chen, Xuwang a Liu, Xin a Meng, Qing a Wang, Ding a Liu, Huiqing a De Clercq, Erik b Pannecouque, Christophe b Balzarini, Jan b Liu, Xinyong a

a SHANDONG UNIVERSITY (China)

b REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

Author keywords

DAPY; Dual conformations; HIV 1 NNRTIs; Molecular hybridization; Piperidin 4 yl aminopyrimidines

Indexed keywords

ANTIVIRUS AGENT; DELAVIRDINE; EFAVIRENZ; ETRAVIRINE; LIGAND; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PIPERIDINYLAMINO DIARYLPYRIMIDINE DERIVATIVE; PROTEIN; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; SOLVENT; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CHEMICAL INTERACTION; CONFORMATION; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR HYBRIDIZATION; MOLECULAR SIZE; NONHUMAN; VIRUS MUTANT; VIRUS STRAIN; WILD TYPE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

DAPY; DUAL CONFORMATIONS; HIV-1 NNRTIS; MOLECULAR HYBRIDIZATION; PIPERIDIN-4-YL-AMINOPYRIMIDINES;

BINDING SITES; DRUG RESISTANCE, VIRAL; ENZYME ACTIVATION; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 84888880978 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.10.059 Document Type: Article

Times cited : (25)

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