Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1565-1568

  Ekkati, Anil R ^a   Bollini, Mariela ^a   Domaoal, Robert A ^b   Spasov, Krasimir A ^b   Anderson, Karen S ^b   Jorgensen, William L ^a  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anti HIV agents; Computer aided drug design; Dimeric inhibitors; NNRTI; Non nucleoside inhibitors of HIV reverse; Transcriptase

Indexed keywords

2 TETRAHYDROPYRANYL; N METHYLPIPERAZINYL; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; TRIAZENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG BINDING SITE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MATHEMATICAL ANALYSIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84856644301     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.132     Document Type: Article

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