Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl) -1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6711-6716

  Cho, Sung Yun ^a   Lee, Byung Ho ^a   Jung, Heejung ^a   Yun, Chang Soo ^a   Ha, Jae Du ^a   Kim, Hyoung Rae ^a   Chae, Chong Hak ^a   Lee, Jeong Hyun ^a   Seo, Ho Won ^a   Oh, Kwang Seok ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Benzoxazole; G protein coupled receptor kinase 2 (GRK 2); GRK 5; Heart failure

Indexed keywords

3 (BENZO[D]OXAZOL 2YL) 5 [1 (PIPERIDIN 4 YL) 1H PYRAZOL 4 YL]PYRIDIN 2 AMINE DERIVATIVE; BENZOXAZOLE DERIVATIVE; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 5; PROTEIN KINASE INHIBITOR; PYRAZOLE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

BENZOXAZOLE; G-PROTEIN-COUPLED RECEPTOR KINASE-2 (GRK-2); GRK-5; HEART FAILURE;

AMINES; BENZOXAZOLES; BINDING SITES; CATALYTIC DOMAIN; DRUG DESIGN; ENZYME ACTIVATION; G-PROTEIN-COUPLED RECEPTOR KINASE 2; G-PROTEIN-COUPLED RECEPTOR KINASE 5; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888879983     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.036     Document Type: Article

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