Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 14, 2010, Pages 4223-4227

  Cho, Sung Yun ^a   Han, Sun Young ^a   Ha, Jae Du ^a   Ryu, Jae Wook ^a   Lee, Chong Ock ^a   Jung, Heejung ^a   Kang, Nam Sook ^a   Kim, Hyoung Rae ^a   Koh, Jong Sung ^a   Lee, Jongkook ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Aminopyridine; Benzoxazole; c Met inhibitor; hERG

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINOPYRIDINE DERIVATIVE; BENZOXAZOLE DERIVATIVE; POTASSIUM CHANNEL HERG; PROTEIN TYROSINE KINASE INHIBITOR; SCATTER FACTOR RECEPTOR;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; AMINOPYRIDINES; ANIMALS; BENZOXAZOLES; DRUG DISCOVERY; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 77953869562     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.031     Document Type: Article

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