메뉴 건너뛰기




Volumn 4, Issue 1, 2012, Pages 15-27

Inhibitors of the cellular trafficking of ricin

Author keywords

Chemical genetics; Retrograde transport; Ricin; Small molecule inhibitor

Indexed keywords

ANTITOXIN; BREFELDIN A; CID 18576762; CID 5737931; CID 644401; EXO2; GOLGICIDE A; ILIMAQUINONE; LG 186; RICIN; SESQUITERPENOID; SHIGA TOXIN; UNCLASSIFIED DRUG;

EID: 84856299619     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins4010015     Document Type: Review
Times cited : (32)

References (54)
  • 1
    • 34748918488 scopus 로고    scopus 로고
    • RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol
    • Smallshaw, J.E.; Richardson, J.A.; Vitetta, E.S. RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol. Vaccine 2007, 25, 7459-7469.
    • (2007) Vaccine , vol.25 , pp. 7459-7469
    • Smallshaw, J.E.1    Richardson, J.A.2    Vitetta, E.S.3
  • 3
    • 0028102678 scopus 로고
    • Identification and characterization of a monoclonal antibody that neutralizes ricin toxicity in vitro and in vivo
    • Lemley, P.V.; Amanatides, P.; Wright, D.C. Identification and characterization of a monoclonal antibody that neutralizes ricin toxicity in vitro and in vivo. Hybridoma 1994, 13, 417-421.
    • (1994) Hybridoma , vol.13 , pp. 417-421
    • Lemley, P.V.1    Amanatides, P.2    Wright, D.C.3
  • 5
    • 0142212317 scopus 로고    scopus 로고
    • Transition state analogues for enzymes of nucleic acid metabolism
    • Schramm, V.L. Transition state analogues for enzymes of nucleic acid metabolism. Nucleic Acids Res. Suppl. 2003, 107-108.
    • (2003) Nucleic Acids Res. Suppl. , pp. 107-108
    • Schramm, V.L.1
  • 6
    • 60049091766 scopus 로고    scopus 로고
    • The X-ray structure of ricin A chain with a novel inhibitor
    • Bai, Y.; Monzingo, A.F.; Robertus, J.D. The X-ray structure of ricin A chain with a novel inhibitor. Arch. Biochem. Biophys. 2009, 483, 23-28.
    • (2009) Arch. Biochem. Biophys. , vol.483 , pp. 23-28
    • Bai, Y.1    Monzingo, A.F.2    Robertus, J.D.3
  • 7
    • 0037011902 scopus 로고    scopus 로고
    • Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition
    • Miller, D.J.; Ravikumar, K.; Shen, H.; Suh, J.K.; Kerwin, S.M.; Robertus, J.D. Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition. J. Med. Chem. 2002, 45, 90-98.
    • (2002) J. Med. Chem. , vol.45 , pp. 90-98
    • Miller, D.J.1    Ravikumar, K.2    Shen, H.3    Suh, J.K.4    Kerwin, S.M.5    Robertus, J.D.6
  • 9
    • 34247857453 scopus 로고    scopus 로고
    • Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design
    • Sturm, M.B.; Roday, S.; Schramm, V.L. Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design. J. Am. Chem. Soc. 2007, 129, 5544-5550.
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 5544-5550
    • Sturm, M.B.1    Roday, S.2    Schramm, V.L.3
  • 11
    • 0034681355 scopus 로고    scopus 로고
    • In vitro selection of RNA molecules that inhibit the activity of ricin A-chain
    • Hesselberth, J.R.; Miller, D.; Robertus, J.; Ellington, A.D. In vitro selection of RNA molecules that inhibit the activity of ricin A-chain. J. Biol. Chem. 2000, 275, 4937-4942.
    • (2000) J. Biol. Chem. , vol.275 , pp. 4937-4942
    • Hesselberth, J.R.1    Miller, D.2    Robertus, J.3    Ellington, A.D.4
  • 13
    • 77955012685 scopus 로고    scopus 로고
    • Identification of new classes of ricin toxin inhibitors by virtual screening
    • Bai, Y.; Watt, B.; Wahome, P.G.; Mantis, N.J.; Robertus, J.D. Identification of new classes of ricin toxin inhibitors by virtual screening. Toxicon 2011, 56, 526-534.
    • (2011) Toxicon , vol.56 , pp. 526-534
    • Bai, Y.1    Watt, B.2    Wahome, P.G.3    Mantis, N.J.4    Robertus, J.D.5
  • 14
    • 77954141743 scopus 로고    scopus 로고
    • Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen
    • Wahome, P.G.; Bai, Y.; Neal, L.M.; Robertus, J.D.; Mantis, N.J. Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen. Toxicon 2010, 56, 313-323.
    • (2010) Toxicon , vol.56 , pp. 313-323
    • Wahome, P.G.1    Bai, Y.2    Neal, L.M.3    Robertus, J.D.4    Mantis, N.J.5
  • 16
    • 34548490308 scopus 로고    scopus 로고
    • Identification and characterization of small molecules that inhibit intracellular toxin transport
    • Saenz, J.B.; Doggett, T.A.; Haslam, D.B. Identification and characterization of small molecules that inhibit intracellular toxin transport. Infect. Immun. 2007, 75, 4552-4561.
    • (2007) Infect. Immun. , vol.75 , pp. 4552-4561
    • Saenz, J.B.1    Doggett, T.A.2    Haslam, D.B.3
  • 17
    • 57749196733 scopus 로고    scopus 로고
    • Tracing the retrograde route in protein trafficking
    • Johannes, L.; Popoff, V. Tracing the retrograde route in protein trafficking. Cell 2008, 135, 1175-1187.
    • (2008) Cell , vol.135 , pp. 1175-1187
    • Johannes, L.1    Popoff, V.2
  • 18
    • 34548288267 scopus 로고    scopus 로고
    • Toxin entry and trafficking in mammalian cells
    • Watson, P.; Spooner, R.A. Toxin entry and trafficking in mammalian cells. Adv. Drug Deliv. Rev. 2006, 58, 1581-1596.
    • (2006) Adv. Drug Deliv. Rev. , vol.58 , pp. 1581-1596
    • Watson, P.1    Spooner, R.A.2
  • 20
    • 30344485142 scopus 로고    scopus 로고
    • Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: Co-opting basic mechanisms of endoplasmic reticulum-associated degradation
    • Lord, J.M.; Roberts, L.M.; Lencer, W.I. Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: Co-opting basic mechanisms of endoplasmic reticulum-associated degradation. Curr. Top. Microbiol. Immunol. 2005, 300, 149-168.
    • (2005) Curr. Top. Microbiol. Immunol. , vol.300 , pp. 149-168
    • Lord, J.M.1    Roberts, L.M.2    Lencer, W.I.3
  • 21
    • 27644531016 scopus 로고    scopus 로고
    • A quantitative and highly sensitive luciferase-based assay for bacterial toxins that inhibit protein synthesis
    • Zhao, L.; Haslam, D.B. A quantitative and highly sensitive luciferase-based assay for bacterial toxins that inhibit protein synthesis. J. Med. Microbiol. 2005, 54, 1023-1030.
    • (2005) J. Med. Microbiol. , vol.54 , pp. 1023-1030
    • Zhao, L.1    Haslam, D.B.2
  • 22
    • 0029083578 scopus 로고
    • Ilimaquinone inhibits the cytotoxicities of ricin, diphtheria toxin, and other protein toxins in Vero cells
    • Nambiar, M.P.; Wu, H.C. Ilimaquinone inhibits the cytotoxicities of ricin, diphtheria toxin, and other protein toxins in Vero cells. Exp. Cell Res. 1995, 219, 671-678.
    • (1995) Exp. Cell Res. , vol.219 , pp. 671-678
    • Nambiar, M.P.1    Wu, H.C.2
  • 23
    • 0027174945 scopus 로고
    • Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone
    • Takizawa, P.A.; Yucel, J.K.; Veit, B.; Faulkner, D.J.; Deerinck, T.; Soto, G.; Ellisman, M.; Malhotra, V. Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone. Cell 1993, 73, 1079-1090.
    • (1993) Cell , vol.73 , pp. 1079-1090
    • Takizawa, P.A.1    Yucel, J.K.2    Veit, B.3    Faulkner, D.J.4    Deerinck, T.5    Soto, G.6    Ellisman, M.7    Malhotra, V.8
  • 24
    • 33846110872 scopus 로고    scopus 로고
    • Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway
    • Lu, P.H.; Chueh, S.C.; Kung, F.L.; Pan, S.L.; Shen, Y.C.; Guh, J.H. Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Eur. J. Pharmacol. 2007, 556, 45-54.
    • (2007) Eur. J. Pharmacol. , vol.556 , pp. 45-54
    • Lu, P.H.1    Chueh, S.C.2    Kung, F.L.3    Pan, S.L.4    Shen, Y.C.5    Guh, J.H.6
  • 25
    • 0033200383 scopus 로고    scopus 로고
    • Interactions of (-)-ilimaquinone with methylation enzymes: Implications for vesicular-mediated secretion
    • Radeke, H.S.; Digits, C.A.; Casaubon, R.L.; Snapper, M.L. Interactions of (-)-ilimaquinone with methylation enzymes: Implications for vesicular-mediated secretion. Chem. Biol. 1999, 6, 639-647.
    • (1999) Chem. Biol. , vol.6 , pp. 639-647
    • Radeke, H.S.1    Digits, C.A.2    Casaubon, R.L.3    Snapper, M.L.4
  • 26
    • 0025975785 scopus 로고
    • Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin
    • Yoshida, T.; Chen, C.C.; Zhang, M.S.; Wu, H.C. Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin. Exp. Cell Res. 1991, 192, 389-395.
    • (1991) Exp. Cell Res. , vol.192 , pp. 389-395
    • Yoshida, T.1    Chen, C.C.2    Zhang, M.S.3    Wu, H.C.4
  • 27
    • 0028811531 scopus 로고
    • Drugs that show protective effects from ricin toxicity in in vitro protein synthesis assays
    • Thompson, W.L.; Scovill, J.P.; Pace, J.G. Drugs that show protective effects from ricin toxicity in in vitro protein synthesis assays. Nat. Toxins 1995, 3, 369-377.
    • (1995) Nat. Toxins. , vol.3 , pp. 369-377
    • Thompson, W.L.1    Scovill, J.P.2    Pace, J.G.3
  • 30
    • 0026353711 scopus 로고
    • Ricin transport in brefeldin A-treated cells: Correlation between Golgi structure and toxic effect
    • Sandvig, K.; Prydz, K.; Hansen, S.H.; van Deurs, B. Ricin transport in brefeldin A-treated cells: Correlation between Golgi structure and toxic effect. J. Cell Biol. 1991, 115, 971-981.
    • (1991) J. Cell Biol. , vol.115 , pp. 971-981
    • Sandvig, K.1    Prydz, K.2    Hansen, S.H.3    van Deurs, B.4
  • 31
    • 0026677375 scopus 로고
    • Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein
    • Donaldson, J.G.; Finazzi, D.; Klausner, R.D. Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein. Nature 1992, 360, 350-352.
    • (1992) Nature , vol.360 , pp. 350-352
    • Donaldson, J.G.1    Finazzi, D.2    Klausner, R.D.3
  • 32
    • 0002955384 scopus 로고    scopus 로고
    • Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: Involvement of specific residues of the Sec7 domain
    • Peyroche, A.; Antonny, B.; Robineau, S.; Acker, J.; Cherfils, J.; Jackson, C.L. Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: Involvement of specific residues of the Sec7 domain. Mol. Cell 1999, 3, 275-285.
    • (1999) Mol. Cell. , vol.3 , pp. 275-285
    • Peyroche, A.1    Antonny, B.2    Robineau, S.3    Acker, J.4    Cherfils, J.5    Jackson, C.L.6
  • 33
    • 0348047597 scopus 로고    scopus 로고
    • Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism
    • Mossessova, E.; Corpina, R.A.; Goldberg, J. Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Mol. Cell 2003, 12, 1403-1411.
    • (2003) Mol. Cell. , vol.12 , pp. 1403-1411
    • Mossessova, E.1    Corpina, R.A.2    Goldberg, J.3
  • 34
    • 23844548266 scopus 로고    scopus 로고
    • Localization and function of Arf family GTPases
    • Donaldson, J.G.; Honda, A. Localization and function of Arf family GTPases. Biochem. Soc. Trans. 2005, 33, 639-642.
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 639-642
    • Donaldson, J.G.1    Honda, A.2
  • 36
    • 0842324801 scopus 로고    scopus 로고
    • The mechanisms of vesicle budding and fusion
    • Bonifacino, J.S.; Glick, B.S. The mechanisms of vesicle budding and fusion. Cell 2004, 116, 153-166.
    • (2004) Cell , vol.116 , pp. 153-166
    • Bonifacino, J.S.1    Glick, B.S.2
  • 37
    • 1842556279 scopus 로고    scopus 로고
    • Adaptable adaptors for coated vesicles
    • Robinson, M.S. Adaptable adaptors for coated vesicles. Trends Cell Biol. 2004, 14, 167-174.
    • (2004) Trends Cell Biol , vol.14 , pp. 167-174
    • Robinson, M.S.1
  • 38
    • 14844333247 scopus 로고    scopus 로고
    • Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi
    • Niu, T.K.; Pfeifer, A.C.; Lippincott-Schwartz, J.; Jackson, C.L. Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi. Mol. Biol. Cell 2005, 16, 1213-1222.
    • (2005) Mol. Biol. Cell. , vol.16 , pp. 1213-1222
    • Niu, T.K.1    Pfeifer, A.C.2    Lippincott-Schwartz, J.3    Jackson, C.L.4
  • 42
    • 4344571004 scopus 로고    scopus 로고
    • Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells
    • Feng, Y.; Jadhav, A.P.; Rodighiero, C.; Fujinaga, Y.; Kirchhausen, T.; Lencer, W.I. Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep. 2004, 5, 596-601.
    • (2004) EMBO Rep , vol.5 , pp. 596-601
    • Feng, Y.1    Jadhav, A.P.2    Rodighiero, C.3    Fujinaga, Y.4    Kirchhausen, T.5    Lencer, W.I.6
  • 45
    • 77956529155 scopus 로고    scopus 로고
    • Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells
    • Guetzoyan, L.J.; Spooner, R.A.; Boal, F.; Stephens, D.J.; Lord, J.M.; Roberts, L.M.; Clarkson, G.J. Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells. Mol. Biosyst. 2010, 6, 2030-2038.
    • (2010) Mol. Biosyst. , vol.6 , pp. 2030-2038
    • Guetzoyan, L.J.1    Spooner, R.A.2    Boal, F.3    Stephens, D.J.4    Lord, J.M.5    Roberts, L.M.6    Clarkson, G.J.7
  • 46
    • 72049083509 scopus 로고    scopus 로고
    • Simple oxidation of pyrimidinylhydrazones to triazolopyrimidines and their inhibition of Shiga toxin trafficking
    • Guetzoyan, L.J.; Spooner, R.A.; Lord, J.M.; Roberts, L.M.; Clarkson, G.J. Simple oxidation of pyrimidinylhydrazones to triazolopyrimidines and their inhibition of Shiga toxin trafficking. Eur. J. Med. Chem. 2010, 45, 275-283.
    • (2010) Eur. J. Med. Chem. , vol.45 , pp. 275-283
    • Guetzoyan, L.J.1    Spooner, R.A.2    Lord, J.M.3    Roberts, L.M.4    Clarkson, G.J.5
  • 47
    • 0037209194 scopus 로고    scopus 로고
    • Shiga toxin B-subunit as a tool to study retrograde transport
    • Mallard, F.; Johannes, L. Shiga toxin B-subunit as a tool to study retrograde transport. Methods Mol. Med. 2003, 73, 209-220.
    • (2003) Methods Mol. Med. , vol.73 , pp. 209-220
    • Mallard, F.1    Johannes, L.2
  • 49
    • 2642520581 scopus 로고    scopus 로고
    • Chemical dimerizers and three-hybrid systems: Scanning the proteome for targets of organic small molecules
    • Kley, N. Chemical dimerizers and three-hybrid systems: Scanning the proteome for targets of organic small molecules. Chem. Biol. 2004, 11, 599-608.
    • (2004) Chem. Biol. , vol.11 , pp. 599-608
    • Kley, N.1
  • 51
    • 79251511501 scopus 로고    scopus 로고
    • Identification of direct protein targets of small molecules
    • Lomenick, B.; Olsen, R.W.; Huang, J. Identification of direct protein targets of small molecules. ACS Chem. Biol. 2011, 6, 34-46.
    • (2011) ACS Chem. Biol. , vol.6 , pp. 34-46
    • Lomenick, B.1    Olsen, R.W.2    Huang, J.3
  • 52
    • 0034646370 scopus 로고    scopus 로고
    • Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors
    • Maly, D.J.; Choong, I.C.; Ellman, J.A. Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors. Proc. Natl. Acad. Sci. USA 2000, 97, 2419-2424.
    • (2000) Proc. Natl. Acad. Sci. USA. , vol.97 , pp. 2419-2424
    • Maly, D.J.1    Choong, I.C.2    Ellman, J.A.3
  • 54
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 2001, 46, 3-26.
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.