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85043573494
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One or two coupled catalytic circles were suggested.50-52 Depending on electron-poor or electron-rich alkynes, a change of mechanisms seems to be reasonable.52 A major problem consists in the deprotonation of terminal alkynes by tert. amines as weak bases. In order to overcome this difficulty, the primary formation of Pd or Cu π-complexes was postulated. However, neither their intermediate formation nor their deprotonation by tert. amines was really proved
-
One or two coupled catalytic circles were suggested.50-52 Depending on electron-poor or electron-rich alkynes, a change of mechanisms seems to be reasonable.52 A major problem consists in the deprotonation of terminal alkynes by tert. amines as weak bases. In order to overcome this difficulty, the primary formation of Pd or Cu π-complexes was postulated. However, neither their intermediate formation nor their deprotonation by tert. amines was really proved.
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86
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45449118137
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-
85043601778
-
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Therefore dialkynes as oxidation products are often minor by-products
-
Therefore dialkynes as oxidation products are often minor by-products.
-
-
-
-
88
-
-
85043582125
-
-
1-I
-
1-I.
-
-
-
-
89
-
-
85043597989
-
-
Highly polar triple bonds can add primary or secondary amines under these conditions. In such cases, only tertiary amines can be used
-
38
-
-
-
-
90
-
-
85043592733
-
-
2,3 Nowadays this group is seldom used.30,31
-
2,3 Nowadays this group is seldom used.30,31
-
-
-
-
91
-
-
85043597059
-
-
3 is possible. Fluoride as base cleaves both silyl groups
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3 is possible. Fluoride as base cleaves both silyl groups.
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-
-
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92
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97
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-
85043606748
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max values. See for example Ref.14
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max values. See for example Ref.14
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98
-
-
85043586385
-
-
F ≤0.1%.
-
F ≤0.1%.
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99
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20344371457
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Meier, H.; Ickenroth, D.; Stalmach, U.; Koynov, K.; Bahtiar, A.; Bubeck, C. Eur. J. Org. Chem. 2001, 4431-4443.
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(2001)
Eur. J. Org. Chem.
, pp. 4431-4443
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Meier, H.1
Ickenroth, D.2
Stalmach, U.3
Koynov, K.4
Bahtiar, A.5
Bubeck, C.6
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