-
1
-
-
0036712905
-
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
-
Gao X., Zhang Y., Arrazola P., Hino O., Kobayashi T., Yeung R.S., Ru B., Pan D. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat. Cell. Biol. 2002, 4:699-704.
-
(2002)
Nat. Cell. Biol.
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
Hino, O.4
Kobayashi, T.5
Yeung, R.S.6
Ru, B.7
Pan, D.8
-
2
-
-
79960387847
-
Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1(mTORC1)
-
Xu L., Salloum D., Medlin P.S., Saqcena M., Yellen P., Perrella B., Foster D.A. Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1(mTORC1). J. Biol. Chem. 2011, 286:25477-25486.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 25477-25486
-
-
Xu, L.1
Salloum, D.2
Medlin, P.S.3
Saqcena, M.4
Yellen, P.5
Perrella, B.6
Foster, D.A.7
-
3
-
-
62849111751
-
Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin
-
Toschi A., Lee E., Xu L., Garcia A., Gadir N., Foster D.A. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol. Cell. Biol. 2009, 29:1411-1420.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 1411-1420
-
-
Toschi, A.1
Lee, E.2
Xu, L.3
Garcia, A.4
Gadir, N.5
Foster, D.A.6
-
4
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K., Li Y., Zhu T., Wu J., Guan K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell. Biol. 2002, 4:648-657.
-
(2002)
Nat. Cell. Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
5
-
-
0032978365
-
Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways
-
Penuel E., Martin G.S. Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways. Mol. Biol. Cell. 1999, 10:1693-1703.
-
(1999)
Mol. Biol. Cell.
, vol.10
, pp. 1693-1703
-
-
Penuel, E.1
Martin, G.S.2
-
6
-
-
0036830564
-
PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival
-
Coutant A., Rescan C., Gilot D., Loyer P., Guguen-Guillouzo C., Baffet G. PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival. Hepatology 2002, 36:1079-1088.
-
(2002)
Hepatology
, vol.36
, pp. 1079-1088
-
-
Coutant, A.1
Rescan, C.2
Gilot, D.3
Loyer, P.4
Guguen-Guillouzo, C.5
Baffet, G.6
-
7
-
-
0029783428
-
Osmoregulation of plasma vasopressin in diabetes mellitus with sustained hyperglycemia
-
Iwasaki Y., Kondo K., Murase T., Hasegawa H., Oiso Y. Osmoregulation of plasma vasopressin in diabetes mellitus with sustained hyperglycemia. J. Neuroendocrinol. 1996, 8:755-760.
-
(1996)
J. Neuroendocrinol.
, vol.8
, pp. 755-760
-
-
Iwasaki, Y.1
Kondo, K.2
Murase, T.3
Hasegawa, H.4
Oiso, Y.5
-
8
-
-
0029813099
-
Plasma and neurohypophyseal content of vasopressin in diabetes mellitus
-
Fujisawa I., Murakami N., Furuto-Kato S., Araki N., Konishi J. Plasma and neurohypophyseal content of vasopressin in diabetes mellitus. J. Clin. Endocrinol. Metab. 1996, 81:2805-2809.
-
(1996)
J. Clin. Endocrinol. Metab.
, vol.81
, pp. 2805-2809
-
-
Fujisawa, I.1
Murakami, N.2
Furuto-Kato, S.3
Araki, N.4
Konishi, J.5
-
9
-
-
0018755966
-
Plasma vasopressin in uncontrolled diabetes mellitus
-
Zerbe R.L., Vinicor F., Robertson G.L. Plasma vasopressin in uncontrolled diabetes mellitus. Diabetes 1979, 28:503-508.
-
(1979)
Diabetes
, vol.28
, pp. 503-508
-
-
Zerbe, R.L.1
Vinicor, F.2
Robertson, G.L.3
-
10
-
-
67650257679
-
Plasma carboxy-terminal provasopressin (copeptin): a novel marker of insulin resistance and metabolic syndrome
-
Saleem U., Khaleghi M., Morgenthaler N.G., Bergmann A., Struck J., Mosley T.H., Kullo I.J. Plasma carboxy-terminal provasopressin (copeptin): a novel marker of insulin resistance and metabolic syndrome. J. Clin. Endocrinol. Metab. 2009, 94:2558-2564.
-
(2009)
J. Clin. Endocrinol. Metab.
, vol.94
, pp. 2558-2564
-
-
Saleem, U.1
Khaleghi, M.2
Morgenthaler, N.G.3
Bergmann, A.4
Struck, J.5
Mosley, T.H.6
Kullo, I.J.7
-
11
-
-
79960087721
-
Plasma copeptin, a unifying factor behind the metabolic syndrome
-
Enhorning S., Struck J., Wirfalt E., Hedblad B., Morgenthaler N.G., Melander O. Plasma copeptin, a unifying factor behind the metabolic syndrome. J. Clin. Endocrinol. Metab. 2011, 96:E1065-1072.
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
-
-
Enhorning, S.1
Struck, J.2
Wirfalt, E.3
Hedblad, B.4
Morgenthaler, N.G.5
Melander, O.6
-
12
-
-
79953300299
-
Diabetes, copeptin levels associate with cardiovascular events in patients with ESRD and type 2 diabetes mellitus
-
Fenske W., Wanner C., Allolio B., Drechsler C., Blouin K., Lilienthal J., Krane V., German D.S.I. Diabetes, copeptin levels associate with cardiovascular events in patients with ESRD and type 2 diabetes mellitus. J. Am. Soc. Nephrol. 2011, 22:782-790.
-
(2011)
J. Am. Soc. Nephrol.
, vol.22
, pp. 782-790
-
-
Fenske, W.1
Wanner, C.2
Allolio, B.3
Drechsler, C.4
Blouin, K.5
Lilienthal, J.6
Krane, V.7
German, D.S.I.8
-
13
-
-
0031971122
-
Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms
-
Melien O., Thoresen G.H., Sandnes D., Ostby E., Christoffersen T. Activation of p42/p44 mitogen-activated protein kinase by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2alpha in hepatocytes is sustained, and like the effect of epidermal growth factor, mediated through pertussis toxin-sensitive mechanisms. J. Cell. Physiol. 1998, 175:348-358.
-
(1998)
J. Cell. Physiol.
, vol.175
, pp. 348-358
-
-
Melien, O.1
Thoresen, G.H.2
Sandnes, D.3
Ostby, E.4
Christoffersen, T.5
-
14
-
-
0034983953
-
Arginine vasopressin stimulates mesangial cell proliferation by activating the epidermal growth factor receptor
-
Ghosh P.M., Mikhailova M., Bedolla R., Kreisberg J.I. Arginine vasopressin stimulates mesangial cell proliferation by activating the epidermal growth factor receptor. Am. J. Physiol. Renal Physiol. 2001, 280:F972-979.
-
(2001)
Am. J. Physiol. Renal Physiol.
, vol.280
-
-
Ghosh, P.M.1
Mikhailova, M.2
Bedolla, R.3
Kreisberg, J.I.4
-
15
-
-
0036080536
-
Vasopressin-mediated mitogenic signaling in intestinal epithelial cells
-
Chiu T., Wu S.S., Santiskulvong C., Tangkijvanich P., Yee H.F., Rozengurt E. Vasopressin-mediated mitogenic signaling in intestinal epithelial cells. Am. J. Physiol. Cell. Physiol. 2002, 282:C434-450.
-
(2002)
Am. J. Physiol. Cell. Physiol.
, vol.282
-
-
Chiu, T.1
Wu, S.S.2
Santiskulvong, C.3
Tangkijvanich, P.4
Yee, H.F.5
Rozengurt, E.6
-
16
-
-
46849101053
-
Vasopressin up-regulates the expression of growth-related immediate-early genes via two distinct EGF receptor transactivation pathways
-
Fuentes L.Q., Reyes C.E., Sarmiento J.M., Villanueva C.I., Figueroa C.D., Navarro J., Gonzalez C.B. Vasopressin up-regulates the expression of growth-related immediate-early genes via two distinct EGF receptor transactivation pathways. Cell. Signal. 2008, 20:1642-1650.
-
(2008)
Cell. Signal.
, vol.20
, pp. 1642-1650
-
-
Fuentes, L.Q.1
Reyes, C.E.2
Sarmiento, J.M.3
Villanueva, C.I.4
Figueroa, C.D.5
Navarro, J.6
Gonzalez, C.B.7
-
17
-
-
54149107123
-
MTOR signaling: PLD takes center stage
-
Sun Y., Chen J. mTOR signaling: PLD takes center stage. Cell Cycle 2008, 7:3118-3123.
-
(2008)
Cell Cycle
, vol.7
, pp. 3118-3123
-
-
Sun, Y.1
Chen, J.2
-
18
-
-
38149018650
-
Diacylglycerol kinases: at the hub of cell signalling
-
Merida I., Avila-Flores A., Merino E. Diacylglycerol kinases: at the hub of cell signalling. Biochem. J. 2008, 409:1-18.
-
(2008)
Biochem. J.
, vol.409
, pp. 1-18
-
-
Merida, I.1
Avila-Flores, A.2
Merino, E.3
-
19
-
-
2442602613
-
Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism
-
Luo B., Prescott S.M., Topham M.K. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism. Cell Signal. 2004, 16:891-897.
-
(2004)
Cell Signal.
, vol.16
, pp. 891-897
-
-
Luo, B.1
Prescott, S.M.2
Topham, M.K.3
-
20
-
-
77953091045
-
Structure of the human mTOR complex I and its implications for rapamycin inhibition
-
Yip C.K., Murata K., Walz T., Sabatini D.M., Kang S.A. Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol. Cell 2010, 38:768-774.
-
(2010)
Mol. Cell
, vol.38
, pp. 768-774
-
-
Yip, C.K.1
Murata, K.2
Walz, T.3
Sabatini, D.M.4
Kang, S.A.5
-
21
-
-
0032549177
-
Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit
-
Leopoldt D., Hanck T., Exner T., Maier U., Wetzker R., Nurnberg B. Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit. J. Biol. Chem. 1998, 273:7024-7029.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 7024-7029
-
-
Leopoldt, D.1
Hanck, T.2
Exner, T.3
Maier, U.4
Wetzker, R.5
Nurnberg, B.6
-
22
-
-
0029090212
-
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
-
Stoyanov B., Volinia S., Hanck T., Rubio I., Loubtchenkov M., Malek D., Stoyanova S., Vanhaesebroeck B., Dhand R., Nurnberg B., et al. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 1995, 269:690-693.
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volinia, S.2
Hanck, T.3
Rubio, I.4
Loubtchenkov, M.5
Malek, D.6
Stoyanova, S.7
Vanhaesebroeck, B.8
Dhand, R.9
Nurnberg, B.10
-
23
-
-
39149097499
-
PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity
-
Ma K., Cheung S.M., Marshall A.J., Duronio V. PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity. Cell Signal. 2008, 20:684-694.
-
(2008)
Cell Signal.
, vol.20
, pp. 684-694
-
-
Ma, K.1
Cheung, S.M.2
Marshall, A.J.3
Duronio, V.4
-
24
-
-
60549096247
-
Akt-dependent and -independent mechanisms of mTOR regulation in cancer
-
Memmott R.M., Dennis P.A. Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal. 2009, 21:656-664.
-
(2009)
Cell Signal.
, vol.21
, pp. 656-664
-
-
Memmott, R.M.1
Dennis, P.A.2
-
25
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N., Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004, 18:1926-1945.
-
(2004)
Genes Dev.
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
26
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic A., Hudson C.C., Homme J.L., Yin P., Otterness D.M., Karnitz L.M., Abraham R.T. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 2000, 60:3504-3513.
-
(2000)
Cancer Res.
, vol.60
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
Yin, P.4
Otterness, D.M.5
Karnitz, L.M.6
Abraham, R.T.7
-
27
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
28
-
-
0026489335
-
Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation
-
Inoguchi T., Battan R., Handler E., Sportsman J.R., Heath W., King G.L. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc. Natl. Acad. Sci. USA 1992, 89:11059-11063.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 11059-11063
-
-
Inoguchi, T.1
Battan, R.2
Handler, E.3
Sportsman, J.R.4
Heath, W.5
King, G.L.6
-
29
-
-
0030863502
-
Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro
-
Williams B., Gallacher B., Patel H., Orme C. Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro. Diabetes 1997, 46:1497-1503.
-
(1997)
Diabetes
, vol.46
, pp. 1497-1503
-
-
Williams, B.1
Gallacher, B.2
Patel, H.3
Orme, C.4
-
30
-
-
0032533546
-
The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2
-
Shaw M., Cohen P., Alessi D.R. The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochem. J. 1998, 336(Pt. 1):241-246.
-
(1998)
Biochem. J.
, vol.336
, Issue.1 PART.
, pp. 241-246
-
-
Shaw, M.1
Cohen, P.2
Alessi, D.R.3
-
31
-
-
79958125269
-
Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells
-
Silva A., Girio A., Cebola I., Santos C.I., Antunes F., Barata J.T. Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells. Leukemia 2011, 25:960-967.
-
(2011)
Leukemia
, vol.25
, pp. 960-967
-
-
Silva, A.1
Girio, A.2
Cebola, I.3
Santos, C.I.4
Antunes, F.5
Barata, J.T.6
-
32
-
-
65549130128
-
MTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability
-
Balcazar N., Sathyamurthy A., Elghazi L., Gould A., Weiss A., Shiojima I., Walsh K., Bernal-Mizrachi E. mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability. J. Biol. Chem. 2009, 284:7832-7842.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 7832-7842
-
-
Balcazar, N.1
Sathyamurthy, A.2
Elghazi, L.3
Gould, A.4
Weiss, A.5
Shiojima, I.6
Walsh, K.7
Bernal-Mizrachi, E.8
-
33
-
-
70449390905
-
Rapamycin and mTOR kinase inhibitors
-
Ballou L.M., Lin R.Z. Rapamycin and mTOR kinase inhibitors. J. Chem. Biol. 2008, 1:27-36.
-
(2008)
J. Chem. Biol.
, vol.1
, pp. 27-36
-
-
Ballou, L.M.1
Lin, R.Z.2
-
34
-
-
0037363926
-
Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells
-
Salazar E.P., Hunger-Glaser I., Rozengurt E. Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells. J. Cell. Physiol. 2003, 194:314-324.
-
(2003)
J. Cell. Physiol.
, vol.194
, pp. 314-324
-
-
Salazar, E.P.1
Hunger-Glaser, I.2
Rozengurt, E.3
|