5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Hohmann, Miriam S N ^a   Cardoso, Renato D R ^a   Pinho Ribeiro, Felipe A ^a   Crespigio, Jefferson ^a   Cunha, Thiago M ^b   Alves Filho, José C ^b   Da Silva, Rosiane V ^a   Pinge Filho, Phileno ^a   Ferreira, Sergio H ^b   Cunha, Fernando Q ^b   Casagrande, Rubia ^a   Verri, Waldiceu A ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); ACETYLGLUCOSAMINIDASE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA INTERFERON; GLUTATHIONE; INTERLEUKIN 10; INTERLEUKIN 1BETA; MESSENGER RNA; MYELOPEROXIDASE; PARACETAMOL; PENTOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SODIUM CHLORIDE; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; ANALGESIC AGENT; ARACHIDONATE 5 LIPOXYGENASE; CYBB PROTEIN, MOUSE; CYTOKINE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

5 LIPOXYGENASE DEFICIENCY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME DEFICIENCY; HEPATITIS; HISTOPATHOLOGY; LETHAL DOSE; LETHALITY; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; TARGET ORGAN; WILD TYPE; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYMOLOGY; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; OXIDATION REDUCTION REACTION; PATHOLOGY; TOXIC HEPATITIS;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CYTOKINES; DRUG-INDUCED LIVER INJURY; INFLAMMATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; NADPH OXIDASE; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; SUPEROXIDES;

EID: 84888616759     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/627046     Document Type: Article

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