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Volumn 57, Issue 5, 2008, Pages 1387-1393

5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE RECEPTOR; SUPEROXIDE; 12 15 LIPOXYGENASE; 12-15-LIPOXYGENASE;

EID: 48449097142     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-1217     Document Type: Article
Times cited : (115)

References (49)
  • 2
    • 33847028707 scopus 로고    scopus 로고
    • Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology
    • Kern TS, Miller CM, Du Y, Zheng L, Mohr S, Ball SL, Kim M, Jamison JA, Bingaman DP: Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. Diabetes 56:373-379, 2007
    • (2007) Diabetes , vol.56 , pp. 373-379
    • Kern, T.S.1    Miller, C.M.2    Du, Y.3    Zheng, L.4    Mohr, S.5    Ball, S.L.6    Kim, M.7    Jamison, J.A.8    Bingaman, D.P.9
  • 3
    • 1542603184 scopus 로고    scopus 로고
    • Potential new strategies to prevent the development of diabetic retinopathy
    • Mohr S: Potential new strategies to prevent the development of diabetic retinopathy. Expert Opin Investig Drugs 13:189-198, 2004
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 189-198
    • Mohr, S.1
  • 4
    • 33847037432 scopus 로고    scopus 로고
    • Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy
    • Zheng L, Howell SJ, Hatala DA, Huang K, Kern TS: Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy. Diabetes 56:337-345, 2007
    • (2007) Diabetes , vol.56 , pp. 337-345
    • Zheng, L.1    Howell, S.J.2    Hatala, D.A.3    Huang, K.4    Kern, T.S.5
  • 5
    • 0037653627 scopus 로고    scopus 로고
    • Endothelial proliferation in diabetic retinal microaneurysms
    • Aguilar E, Friedlander M, Gariano RF: Endothelial proliferation in diabetic retinal microaneurysms. Arch Ophthalmol 121:740-741, 2003
    • (2003) Arch Ophthalmol , vol.121 , pp. 740-741
    • Aguilar, E.1    Friedlander, M.2    Gariano, R.F.3
  • 6
    • 0014114595 scopus 로고
    • The mural cell in perspective
    • Cogan DG, Kuwabara T: The mural cell in perspective. Arch Ophthalmol 78:133-139, 1967
    • (1967) Arch Ophthalmol , vol.78 , pp. 133-139
    • Cogan, D.G.1    Kuwabara, T.2
  • 7
    • 0024420402 scopus 로고
    • Pathogenesis of diabetic retinopathy
    • Engerman RL: Pathogenesis of diabetic retinopathy. Diabetes 38:1203-1206, 1989
    • (1989) Diabetes , vol.38 , pp. 1203-1206
    • Engerman, R.L.1
  • 8
    • 0031737671 scopus 로고    scopus 로고
    • Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: Vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group
    • Antonetti DA, Barber AJ, Khin S, Lieth E, Tarbell JM, Gardner TW: Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Diabetes 47:1953-1959, 1998
    • (1998) Diabetes , vol.47 , pp. 1953-1959
    • Antonetti, D.A.1    Barber, A.J.2    Khin, S.3    Lieth, E.4    Tarbell, J.M.5    Gardner, T.W.6
  • 9
    • 0033374116 scopus 로고    scopus 로고
    • Molecular mechanisms of vascular permeability in diabetic retinopathy
    • Antonetti DA, Lieth E, Barber AJ, Gardner TW: Molecular mechanisms of vascular permeability in diabetic retinopathy. Semin Ophthalmol 14:240-248, 1999
    • (1999) Semin Ophthalmol , vol.14 , pp. 240-248
    • Antonetti, D.A.1    Lieth, E.2    Barber, A.J.3    Gardner, T.W.4
  • 10
    • 0344012015 scopus 로고    scopus 로고
    • Hyperglycemia increases mitochondrial super-oxide in retina and retinal cells
    • Du Y, Miller CM, Kern TS: Hyperglycemia increases mitochondrial super-oxide in retina and retinal cells. Free Radic Biol Med 35:1491-1499, 2003
    • (2003) Free Radic Biol Med , vol.35 , pp. 1491-1499
    • Du, Y.1    Miller, C.M.2    Kern, T.S.3
  • 11
    • 0034468677 scopus 로고    scopus 로고
    • New insights into the pathophysiology of diabetic retinopathy: Potential cell-specific therapeutic targets
    • Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Nakamura M: New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets. Diabetes Technol Ther 2:601-608, 2000
    • (2000) Diabetes Technol Ther , vol.2 , pp. 601-608
    • Gardner, T.W.1    Antonetti, D.A.2    Barber, A.J.3    LaNoue, K.F.4    Nakamura, M.5
  • 12
    • 0035986498 scopus 로고    scopus 로고
    • Retinal metabolic abnormalities in diabetic mouse: Comparison with diabetic rat
    • Kowluru RA: Retinal metabolic abnormalities in diabetic mouse: comparison with diabetic rat. Curr Eye Res 24:123-128, 2002
    • (2002) Curr Eye Res , vol.24 , pp. 123-128
    • Kowluru, R.A.1
  • 13
    • 7044229731 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB
    • Zheng L, Szabo C, Kern TS: Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. Diabetes 53:2960-2967, 2004
    • (2004) Diabetes , vol.53 , pp. 2960-2967
    • Zheng, L.1    Szabo, C.2    Kern, T.S.3
  • 15
    • 34247394257 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy [Review]
    • Kowluru RA, Chan PS: Oxidative stress and diabetic retinopathy [Review]. Exp Diabetes Res 2007:43603, 2007
    • (2007) Exp Diabetes Res , vol.2007 , pp. 43603
    • Kowluru, R.A.1    Chan, P.S.2
  • 17
    • 20444376222 scopus 로고    scopus 로고
    • 5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration
    • Cuzzocrea S, Rossi A, Mazzon E, Di Paola R, Genovese T, Muia C, Caputi AP, Sautebin L: 5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration. Lab Invest 85: 808-822, 2005
    • (2005) Lab Invest , vol.85 , pp. 808-822
    • Cuzzocrea, S.1    Rossi, A.2    Mazzon, E.3    Di Paola, R.4    Genovese, T.5    Muia, C.6    Caputi, A.P.7    Sautebin, L.8
  • 18
    • 34247541994 scopus 로고    scopus 로고
    • Pharmacotherapy of diseases mediated by 5-lipoxy-genase pathway eicosanoids
    • Rubin P, Mollison KW: Pharmacotherapy of diseases mediated by 5-lipoxy-genase pathway eicosanoids. Prostaglandins Other Lipid Mediat 83:188-197, 2007
    • (2007) Prostaglandins Other Lipid Mediat , vol.83 , pp. 188-197
    • Rubin, P.1    Mollison, K.W.2
  • 19
    • 33646245920 scopus 로고    scopus 로고
    • The role of leukotrienes in the pathophysiol-ogy of inflammatory disorders: Is there a case for revisiting leukotrienes as therapeutic targets?
    • Sharma JN, Mohammed LA: The role of leukotrienes in the pathophysiol-ogy of inflammatory disorders: is there a case for revisiting leukotrienes as therapeutic targets? Inflammopharmacology 14:10-16, 2006
    • (2006) Inflammopharmacology , vol.14 , pp. 10-16
    • Sharma, J.N.1    Mohammed, L.A.2
  • 21
    • 33747806260 scopus 로고    scopus 로고
    • Leukotriene B4 receptors BLT1 and BLT2: Expression and function in human and murine mast cells
    • Lundeen KA, Sun B, Karlsson L, Fourie AM: Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells. J Immunol 177:3439-3447, 2006
    • (2006) J Immunol , vol.177 , pp. 3439-3447
    • Lundeen, K.A.1    Sun, B.2    Karlsson, L.3    Fourie, A.M.4
  • 22
    • 0036759271 scopus 로고    scopus 로고
    • Arachidonic acid cytotoxicity in leukocytes: Implications of oxidative stress and eicosanoid synthesis
    • Pompeia C, Freitas JJ, Kim JS, Zyngier SB, Curi R: Arachidonic acid cytotoxicity in leukocytes: implications of oxidative stress and eicosanoid synthesis. Biol Cell 94:251-265, 2002
    • (2002) Biol Cell , vol.94 , pp. 251-265
    • Pompeia, C.1    Freitas, J.J.2    Kim, J.S.3    Zyngier, S.B.4    Curi, R.5
  • 23
    • 33745311143 scopus 로고    scopus 로고
    • The mast cell and the cysteinyl leukotrienes
    • discussion 176-178, 198-199
    • Austen KF: The mast cell and the cysteinyl leukotrienes. Novartis Found Symp 271:166-175 [discussion 176-178, 198-199], 2005
    • (2005) Novartis Found Symp , vol.271 , pp. 166-175
    • Austen, K.F.1
  • 24
    • 0023259710 scopus 로고
    • Leukotrienes: Role in cardiovascular physiology
    • Letts LG: Leukotrienes: role in cardiovascular physiology. Cardiovasc Clin 18:101-113, 1987
    • (1987) Cardiovasc Clin , vol.18 , pp. 101-113
    • Letts, L.G.1
  • 25
    • 33745190052 scopus 로고    scopus 로고
    • The 5 lipoxygenase system in the vasculature: Emerging role in health and disease
    • Osher E, Weisinger G, Limor R, Tordjman K, Stern N: The 5 lipoxygenase system in the vasculature: emerging role in health and disease. Mol Cell Endocrinol 252:201-206, 2006
    • (2006) Mol Cell Endocrinol , vol.252 , pp. 201-206
    • Osher, E.1    Weisinger, G.2    Limor, R.3    Tordjman, K.4    Stern, N.5
  • 26
    • 33748684386 scopus 로고    scopus 로고
    • Eicosanoid transcellular biosynthesis: From cell-cell interactions to in vivo tissue responses
    • Folco G, Murphy RC: Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol Rev 58:375-388, 2006
    • (2006) Pharmacol Rev , vol.58 , pp. 375-388
    • Folco, G.1    Murphy, R.C.2
  • 27
    • 33947168280 scopus 로고    scopus 로고
    • Biosynthesis of eicosanoids and transcel-lular metabolism of leukotrienes in murine bone marrow cells
    • Gijon MA, Zarini S, Murphy RC: Biosynthesis of eicosanoids and transcel-lular metabolism of leukotrienes in murine bone marrow cells. J Lipid Res 48:716-725, 2007
    • (2007) J Lipid Res , vol.48 , pp. 716-725
    • Gijon, M.A.1    Zarini, S.2    Murphy, R.C.3
  • 28
    • 0036160759 scopus 로고    scopus 로고
    • Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model
    • Natarajan R, Gerrity RG, Gu JL, Lanting L, Thomas L, Nadler JL: Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model. Diabetologia 45:125-133, 2002
    • (2002) Diabetologia , vol.45 , pp. 125-133
    • Natarajan, R.1    Gerrity, R.G.2    Gu, J.L.3    Lanting, L.4    Thomas, L.5    Nadler, J.L.6
  • 29
    • 33745039531 scopus 로고    scopus 로고
    • 12/15 lipoxy-genase mediates monocyte adhesion to aortic endothelium in apolipopro-tein E-deficient mice through activation of RhoA and NF-kappaB
    • Bolick DT, Srinivasan S, Whetzel A, Fuller LC, Hedrick CC: 12/15 lipoxy-genase mediates monocyte adhesion to aortic endothelium in apolipopro-tein E-deficient mice through activation of RhoA and NF-kappaB. Arterioscler Thromb Vasc Biol 26:1260-1266, 2006
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1260-1266
    • Bolick, D.T.1    Srinivasan, S.2    Whetzel, A.3    Fuller, L.C.4    Hedrick, C.C.5
  • 31
    • 4344620045 scopus 로고    scopus 로고
    • Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide
    • Lebeau A, Terro F, Rostene W, Pelaprat D: Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide. Cell Death Differ 11:875-884, 2004
    • (2004) Cell Death Differ , vol.11 , pp. 875-884
    • Lebeau, A.1    Terro, F.2    Rostene, W.3    Pelaprat, D.4
  • 32
    • 27644571486 scopus 로고    scopus 로고
    • 12/15-lipoxygenase regulates intercellular adhesion mole-cule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB
    • Bolick DT, Orr AW, Whetzel A, Srinivasan S, Hatley ME, Schwartz MA, Hedrick CC: 12/15-lipoxygenase regulates intercellular adhesion mole-cule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB. Arterioscler Thromb Vasc Biol 25:2301-2307, 2005
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2301-2307
    • Bolick, D.T.1    Orr, A.W.2    Whetzel, A.3    Srinivasan, S.4    Hatley, M.E.5    Schwartz, M.A.6    Hedrick, C.C.7
  • 33
    • 13944275857 scopus 로고    scopus 로고
    • Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs
    • Li SL, Dwarakanath RS, Cai Q, Lanting L, Natarajan R: Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs. J Lipid Res 46:220-229, 2005
    • (2005) J Lipid Res , vol.46 , pp. 220-229
    • Li, S.L.1    Dwarakanath, R.S.2    Cai, Q.3    Lanting, L.4    Natarajan, R.5
  • 34
    • 0032723345 scopus 로고    scopus 로고
    • Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice
    • Bleich D, Chen S, Zipser B, Sun D, Funk CD, Nadler JL: Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice. J Clin Invest 103:1431-1436, 1999
    • (1999) J Clin Invest , vol.103 , pp. 1431-1436
    • Bleich, D.1    Chen, S.2    Zipser, B.3    Sun, D.4    Funk, C.D.5    Nadler, J.L.6
  • 35
    • 0035409354 scopus 로고    scopus 로고
    • Pharmacological inhibition of diabetic retinopa-thy: Aminoguanidine and aspirin
    • Kern TS, Engerman RL: Pharmacological inhibition of diabetic retinopa-thy: aminoguanidine and aspirin. Diabetes 50:1636-1642, 2001
    • (2001) Diabetes , vol.50 , pp. 1636-1642
    • Kern, T.S.1    Engerman, R.L.2
  • 36
    • 0043207639 scopus 로고    scopus 로고
    • Non-uniform distribution of lesions and biochemical abnormalities within the retina of diabetic humans
    • Tang J, Mohr S, Du YD, Kern TS: Non-uniform distribution of lesions and biochemical abnormalities within the retina of diabetic humans. Curr Eye Res 27:7-13, 2003
    • (2003) Curr Eye Res , vol.27 , pp. 7-13
    • Tang, J.1    Mohr, S.2    Du, Y.D.3    Kern, T.S.4
  • 37
    • 19944432813 scopus 로고    scopus 로고
    • Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: Improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking
    • Mustata GT, Rosca M, Biemel KM, Reihl O, Smith MA, Viswanathan A, Strauch C, Du Y, Tang J, Kern TS, Lederer MO, Brownlee M, Weiss MF, Monnier VM: Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking. Diabetes 54:517-526, 2005
    • (2005) Diabetes , vol.54 , pp. 517-526
    • Mustata, G.T.1    Rosca, M.2    Biemel, K.M.3    Reihl, O.4    Smith, M.A.5    Viswanathan, A.6    Strauch, C.7    Du, Y.8    Tang, J.9    Kern, T.S.10    Lederer, M.O.11    Brownlee, M.12    Weiss, M.F.13    Monnier, V.M.14
  • 38
    • 34648825492 scopus 로고    scopus 로고
    • Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dis-mutase
    • Kanwar M, Chan PS, Kern TS, Kowluru RA: Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dis-mutase. Invest Ophthalmol Vis Sci 48:3805-3811, 2007
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3805-3811
    • Kanwar, M.1    Chan, P.S.2    Kern, T.S.3    Kowluru, R.A.4
  • 39
    • 6344285417 scopus 로고    scopus 로고
    • Endothelial cell superoxide generation: Regulation and relevance for cardiovascular pathophysiology
    • Li JM, Shah AM: Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am J Physiol Regul Integr Comp Physiol 287:R1014-R1030, 2004
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.287
    • Li, J.M.1    Shah, A.M.2
  • 40
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • Brownlee M: The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54:1615-1625, 2005
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 41
    • 25644437130 scopus 로고    scopus 로고
    • Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in poly-unsaturated fatty acid-stimulated neutrophils
    • Serezani CH, Aronoff DM, Jancar S, Peters-Golden M: Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in poly-unsaturated fatty acid-stimulated neutrophils. J Leukoc Biol 78:976-984, 2005
    • (2005) J Leukoc Biol , vol.78 , pp. 976-984
    • Serezani, C.H.1    Aronoff, D.M.2    Jancar, S.3    Peters-Golden, M.4
  • 44
    • 33947269798 scopus 로고    scopus 로고
    • Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation
    • Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, Serhan CN: Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J Immunol 178:3912-3917, 2007
    • (2007) J Immunol , vol.178 , pp. 3912-3917
    • Arita, M.1    Ohira, T.2    Sun, Y.P.3    Elangovan, S.4    Chiang, N.5    Serhan, C.N.6
  • 45
    • 28444431957 scopus 로고    scopus 로고
    • Leuko-triene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia
    • Back M, Bu DX, Branstrom R, Sheikine Y, Yan ZQ, Hansson GK: Leuko-triene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. Proc Natl Acad SciUSA 102:17501-17506, 2005
    • (2005) Proc Natl Acad SciUSA , vol.102 , pp. 17501-17506
    • Back, M.1    Bu, D.X.2    Branstrom, R.3    Sheikine, Y.4    Yan, Z.Q.5    Hansson, G.K.6
  • 47
    • 16844368834 scopus 로고    scopus 로고
    • Lohmussaar E, Gschwendtner A, Mueller JC, Org T, Wichmann E, Hamann G, Meitinger T, Dichgans M: ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. Stroke 36:731-736, 2005
    • Lohmussaar E, Gschwendtner A, Mueller JC, Org T, Wichmann E, Hamann G, Meitinger T, Dichgans M: ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. Stroke 36:731-736, 2005
  • 48
    • 0035071318 scopus 로고    scopus 로고
    • 12-lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy
    • Kang SW, Adler SG, Nast CC, LaPage J, Gu JL, Nadler JL, Natarajan R: 12-lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy. Kidney Int 59:1354-1362, 2001
    • (2001) Kidney Int , vol.59 , pp. 1354-1362
    • Kang, S.W.1    Adler, S.G.2    Nast, C.C.3    LaPage, J.4    Gu, J.L.5    Nadler, J.L.6    Natarajan, R.7
  • 49
    • 34547399482 scopus 로고    scopus 로고
    • High-fat diet induced neuropathy of pre-diabetes and obesity: Effects of "healthy" diet and aldose reductase inhibition
    • Obrosova IG, Ilnytska O, Lyzogubov VV, Pavlov IA, Mashtalir N, Nadler JL, Drel VR: High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition. Diabetes 56:2598-2608, 2007
    • (2007) Diabetes , vol.56 , pp. 2598-2608
    • Obrosova, I.G.1    Ilnytska, O.2    Lyzogubov, V.V.3    Pavlov, I.A.4    Mashtalir, N.5    Nadler, J.L.6    Drel, V.R.7


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