Hydrogen sulphide production by bottom-fermenting yeast is related to nitrogen starvation signalling

Journal of the Institute of Brewing

Volumn 119, Issue 4, 2013, Pages 228-236

  Ogata, Tomoo ^a  

^a ASAHI BREWERIES LTD   (Japan)

Author keywords

Bottom fermenting yeast; Hydrogen sulphide; Nitrogen catabolite repression; Nitrogen starvation signal; Thiol off flavour compounds

Indexed keywords

FLAVOR COMPOUNDS; HYDROGEN SULFIDE; SULFUR COMPOUNDS; TRANSCRIPTION; YEAST;

EXPONENTIAL GROWTH; NITROGEN CATABOLITE REPRESSION; NITROGEN STARVATION; PARENT STRAIN; SENSITIVE GENES; SULPHIDE PRODUCTIONS; YEAST STRAIN;

HYDROGEN PRODUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 84888438909     PISSN: 00469750     EISSN: 20500416     Source Type: Journal    
DOI: 10.1002/jib.96     Document Type: Article

References (43)

1. Olsen, A., Christensen, B. W., and Madsen, J. Ø. (1988) Onion-like off-flavour in beer: isolation and identification of the culprits. Carlsberg Res. Commun., 53, 1-9.
2. Vermeulen, C., Lejeune, I., Tran, T. H., and Collin, S. (2006) Occurrence of polyfunctional thiols in fresh lager beers. J. Agric. Food Chem., 54, 5061-5068.
3. Giudici, P. and Kunkee, R. E. (1994) The effect of nitrogen deficiency and sulfur-containing amino acids on the reduction of sulfate to hydrogen sulphide by wine yeasts. Am. J. Enol. Vitic., 45, 107-112.
4. Jiranek, V., Langridge, P., and Henschke, P. A. (1995) Regulation of hydrogen sulphide liberation in wine-producing Saccharomyces cerevisiae strains by assimilable nitrogen. Appl. Environ. Microbiol., 61, 461-467.
5. Spiropoulos, A. and Bisson, L. (2000) MET17 and hydrogen sulphide formation in Saccharomyces cerevisiae. Appl. Environ. Microbiol., 66, 4421-4426.
6. 2 formation by brewing yeast in response to sulfur-containing amino acids and ammonium ions. J. Am. Soc. Brew. Chem., 62, 35-41.
7. Mendes-Ferreira, A., Barbosa, C., Falco, V., Leão, C., and Mendes-Faia, A. (2009) The production of hydrogen sulphide and other aroma compounds by wine strains of Saccharomyces cerevisiae in synthetic media with different nitrogen concentrations. J. Ind. Microbiol. Biotechnol., 36, 571-583.
8. Gibson, B. R., Lawrence, S. J., Leclaire, J. P. R., Powell, C. D., and Smart, K. A. (2007) Yeast responses to stresses associated with industrial brewery handling. FEMS Micorobiol. Rev., 31, 535-569.
9. Olsen, K., Felding, T., Gjermansen, C., and Hansen, J. (2002) The dynamics of the Saccharomyces carlsbergensis brewing yeast transcriptome during a production-scale lager beer fermentation. FEMS Yeast Res., 2, 563-573.
10. Higgins, V. J., Beckhouse, A. G., Oliver, A. D., Rogers, P. J., and Dawes, I. W. (2003) Yeast genome-wide expression analysis identifies a strong ergosterol and oxidative stress response during the initial stages of an industrial lager fermentation. Appl. Environ. Microbiol., 69, 4777-4787.
11. Higgins, V. J., Rogers, P. J., and Dawes, I. (2003) Application of genome-wide expression analysis to identify molecular markers useful in monitoring industrial fermentations. Appl. Environ. Microbiol., 69, 7553-7540.
12. Smart, K. (2007) Brewing yeast genomes and genome-wide expression and proteome profiling during fermentation. Yeast, 24, 993-1013.
13. Gibson, B. R., Boulton, C. A., Box, W. G., Graham, N. S., Lawrence, S. J., Linforth, R. S. T., and Smart, K. A. (2008) Carbohydrate utilization and the lager yeast transcriptome during brewery fermentation. Yeast, 25, 549-562.
14. Gibson, B. R., Graham, N. S., Boulton, C. A., Box, W. G., Lawrence, S. J., Linforth, R. S. T., May, S. T., and Smart, K. A. (2010) Differential yeast gene transcription during brewery propagation. J. Am. Soc. Brew. Chem., 68, 21-29.
15. Hofman-Bang, J. (1999) Nitrogen catabolite repression in Saccharomyces cerevisiae. Mol. Biotechnol., 12, 35-73.
16. ter Schure, E. G., van Riel, N. A. W., and Verrips, C. T. (2000) The role of ammonia metabolism in nitrogen catabolite repression in Saccharomyces cerevisiae. FEMS Microbiol. Rev., 24, 67-83.
17. Cooper, T. G. (2002) Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: connecting the dots. FEMS Microbiol. Rev., 26, 223-238.
18. Magasanik, B. and Kaiser, C. A. (2002) Nitrogen regulation in Saccharomyces cerevisiae. Gene, 209, 1-18.
19. Winderickx, J., Holsbeeks, I., Lagatie, O., Giots, F., Thevelein, J., and de Winde, H. (2003) From feast to famine; adaptation to nutrient availability in yeast, in Topics in Current Genetics, Vol. 1, Yeast Stress Responses ( Hohmann, S. and Mager, P. W. H. Eds.) pp. 305-386, Springer, Berlin.
20. Coffman, J. A., Rai, R., Cunningham, T., Svetlov, V., and Cooper, T. G. (1996) Gat1p, a GATA family protein whose production in sensitive to nitrogen catabolite repression, participates in transcriptional activation of nitrogen-catabolite genes in Saccharomyces cerevisiae. Mol. Cell. Biol., 16, 847-858.
21. Stanbrough, M. and Magasanik, B. (1996) Two transcription factors, Gln3p and Nil1p, use the same GATAAG sites to activate the expression of GAP1 of Saccharomyces cerevisiae. J. Bacteriol., 178, 2465-2468.
22. Coffman, J. A., Rai, R., Loprete, D. M., Cunningham, T., Svetlov, V., and Cooper, T. G. (1997) Cross regulation of four GATA factors that control nitrogen catabolite gene expression in Saccharomyces cerevisiae. J. Bacteriol., 179, 3416-3429.
23. Cunningham, T. and Cooper, T. G. (1991) Expression of the DAL80 gene, whose product is homologous to the GATA factors and is a negative regulator of multiple nitrogen catabolic genes in Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression. Mol. Cell. Biol., 11, 6205-6215.
24. Cox, K. H., Rai, R., Distler, M., Daugherty, J. R., Coffman, J. A., and Cooper, T. G. (2000) Saccharomyces cerevisiae GATA sequence function as TATA elements during nitrogen catabolite repression and when Gln3p is excluded from the nucleus by overproduction of Ure2p. J. Biol. Chem., 275, 17611-17618.
25. Ogata, T. (2012) Nitrogen starvation induces expression of Lg-FLO1 and flocculation in bottom-fermenting yeast. Yeast, 29, 487-494.
26. Tamai, Y., Momma, T., Yoshimoto, H., and Kaneko, Y. (1998) Co-existence of two types of chromosome in the bottom fermenting yeast, Saccharomyces pastorianus. Yeast, 14, 923-933.
27. Vaughan-Martini, A. and Martini, A. (1998) Saccharomyces Meyen ex Reess, in The Yeasts, a Taxonomic Study ( Kurtzman, C. P. and Fell, J. W. Eds.) 4th ed., pp. 358-371, Elsevier, Amsterdam.
28. Yamagishi, H. and Ogata, T. (1999) Chromosomal structures of bottom fermenting yeasts. Syst. Appl. Microbiol., 22, 341-353.
29. Casaregola, S., Nguyen, H. V., Lapathitis, G., Kotyk, A., and Gaillardin, C. (2001) Analysis of the constitution of the beer yeast genome by PCR, sequencing and subtelomeric sequence hybridization. Int. J. Syst. Evol. Microbiol., 51, 1607-1618.
30. Rainieri, S., Kodama, Y., Kaneko, Y., Mikata, K., Nakao, Y., and Ashikari, T. (2006) Pure and mixed genetic lines of Saccharomyces bayanus and Saccharomyces pastorianus and their contribution to the lager brewing strain genome. Appl. Environ. Microbiol., 72, 3968-3974.
31. Dunn, B. and Sherlock, G. (2008) Reconstruction of the genome origins and evolution of the hybrid lager yeast Saccharomyces pastorianus. Genome Res., 18, 1610-1623.
32. Nakao, Y., Kanamori, T., Itoh, T., Kodama, Y., Rainieri, S., Nakamura, N., Shimonaga, T., Hattori, M., and Ashikari, T. (2009) Genome sequence of the lager brewing yeast, an interspecies hybrid. DNA Res., 16, 115-129.
33. Libkind, D., Hittinger, C. T., Valério, E., Gonçalves, C., Dover, J., Johnston, M., Gonçalves, P., and Sampaio, J. P. (2011) Microbe domestication and the identification of the wild genetic stock of lager-brewing yeast. Proc. Natl. Acad. Sci. U. S. A., 108, 14539-14544.
34. Ogata, T., Shikata-Miyoshi, M., Tadami, H., and Nakazawa, N. (2011) Isolation of meiotic segregants from bottom fermenting yeast. J. Inst. Brew., 117, 199-205.
35. Iijima, K. and Ogata, T. (2010) Construction and evaluation of self-cloning bottom-fermenting yeast with high SSU1 expression. J. Appl. Microbiol., 109, 1906-1913.
36. Ogata, T., Okumura, Y., Tadenuma, M., and Tamura, G. (1993) Improving transformation method for industrial yeasts: construction of ADH1-APT2 gene and using electroporation. J. Gen. Appl. Microbiol., 39, 285-294.
37. Akada, R., Shimizu, Y., Matsushita, Y., Kawahata, M., Hoshida, H., and Nishizawa, Y. (2002) Use of a YAP1 overexpression cassette conferring specific resistance to cerulenin and cycloheximide as an efficient selectable marker in the yeast Saccharomyces cerevisiae. Yeast, 19, 17-28.
38. Ogata, T., Yamagishi, H., Ukibe, K., and Takagi, H. (2012) Construction of bottom-fermenting yeasts that over express the ubiquitin ligase RSP5 gene and their effects on high-gravity fermentation. J. Brew. Distill., 3, 1-5.
39. Cha-aim, K., Fukunaga, T., Hoshida, H., and Akada, R. (2009) Reliable fusion PCR mediated by GC-rich overlap sequences. Gene, 434, 43-49.
40. Omura, F. and Shibano, Y. (1995) Reduction of hydrogen sulphide production in brewing yeast by constitutive expression of MET25 gene. J. Am. Soc. Brew. Chem., 53, 58-62.
41. 2 formation during beer production. Nat. Biotechnol., 14, 1587-1591.
42. Yamagishi, H., Ohnuki, S., Nogami, S., Ogata, T., and Ohya, Y. (2010) Role of bottom-fermenting brewer's yeast KEX2 in high temperature resistance and poor proliferation at low temperatures. J. Gen. Appl. Microbiol., 56, 297-312.
43. Harsch, M. J. and Gardner, R. C. (2013) Yeast genes involved in sulfur and nitrogen metabolism affect the production of volatile thiols from Sauvignon Blanc musts. Appl. Microbiol. Biotech., 97, 223-235.