Synthesis, cytotoxic evaluation and molecular docking study of 2-alkylthio-4-(2,3,4-trimethoxyphenyl)-5-aryl-thiazoles as tubulin polymerization inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 24, 2013, Pages 7648-7654

  Salehi, Marjan ^a   Amini, Mohsen ^a   Ostad, Seyed Nasser ^b   Riazi, Gholam Hossein ^c   Assadieskandar, Amir ^a   Shafiei, Bentolhoda ^c   Shafiee, Abbas ^d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF TEHRAN   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

2 Alkylthio 4,5 diaryl thiazole; Cell cycle analysis; Cytotoxicity; Molecular docking; Tubulin inhibitor

Indexed keywords

2 ALKYLTHIO 4 (2,3,4 TRIMETHOXYPHENYL) 5 ARYL THIAZOLE DERIVATIVE; 4 (2,3,4 TRIMETHOXYPHENYL) 5 (4 CHLOROPHENYL) 2 (METHYLTHIO)THIAZOLE; 4 (2,3,4 TRIMETHOXYPHENYL) 5 (4 CHOLOROPHENYL) 2 (BENZYLTHIO)THIAZOLE; 4 (2,3,4 TRIMETHOXYPHENYL) 5 (4 FLOUROPHENYL) 2 (BENZYLTHIO)THIAZOLE; 4 (2,3,4 TRIMETHOXYPHENYL) 5 (4 FLOUROPHENYL) 2 (METHYLTHIO)THIAZOLE; 4 (2,3,4 TRIMETHOXYPHENYL) 5 (4 NITROPHENYL) 2 (BENZYLTHIO)THIAZOLE; 4 (2,3,4 TRIMETHOXYPHENYL) 5 (4 NITROPHENYL) 2 (METHYLTHIO)THIAZOLE; 4 (2,3,4 TRIMETHOXYPHENYL) 5 (PHENYL) 2 (BENZYLTHIO)THIAZOLE; 4 (2,3,4 TRIMETHOXYPHENYL) 5 (PHENYL) 2 (METHYLTHIO)THIAZOLE; ALPHA TUBULIN; ANTINEOPLASTIC AGENT; BETA TUBULIN; COLCHICINE; COMBRETASTATIN A4; PROTEIN INHIBITOR; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL STRAIN AGS; CELL STRAIN HT29; CELL STRAIN MCF 7; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FIBROBLAST CULTURE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; IN VITRO STUDY; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

2-ALKYLTHIO-4,5-DIARYL-THIAZOLE; CELL CYCLE ANALYSIS; CYTOTOXICITY; MOLECULAR DOCKING; TUBULIN INHIBITOR;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; MCF-7 CELLS; MICE; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; NIH 3T3 CELLS; POLYMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TUBULIN;

EID: 84888435334     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.10.030     Document Type: Article

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