Design, synthesis, cytotoxic evaluation and tubulin inhibitory activity of 4-aryl-5-(3,4,5-trimethoxyphenyl)-2-alkylthio-1H-imidazole derivatives

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 10, 2013, Pages 2703-2709

  Assadieskandar, Amir ^a   Amini, Mohsen ^a   Ostad, Seyed Nasser ^b   Riazi, Gholam Hossein ^c   Cheraghi Shavi, Tayebe ^c   Shafiei, Bentolhoda ^c   Shafiee, Abbas ^d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF TEHRAN   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

2 Alkylthio 1H imidazole; Cell cycle analysis; Cytotoxicity activity; Tautomerization; Tubulin polymerization

Indexed keywords

2 (EHYLTHIO) 5 (2 METHOXYPHENYL) 4 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDAZOLE; 2 (ETHYLTHIO) 4,5 BIS(3,4,5 TRIMETHOXY PHENYL) 1H IMIDAZOLE; 2 (ETHYLTHIO) 5 (4 METHOXYPHENYL) 4 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDAZOLE; 2 (METHYLTHIO) 4,5 BIS(3,4,5 TRIMETHOXY PHENYL) 1H IMIDAZOLE; 4 ARYL 5 (3,4,5 TRIMETHOXYPHENYL) 2 ALKYLTHIO 1H IMIDAZOLE DERIVATIVE; 4,5 BIS(3,4 DIMETHOXYPHENYL ) 2 (ETHYLTHIO) 1H IMIDAZOLE; 4,5 BIS(3,4 DIMETHOXYPHENYL ) 2 (METHYLTHIO) 1H IMIDAZOLE; 5 (2 METHOXYPHENYL) 2 (METHYLTHIO) 4 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDAZOLE; 5 (2,3 DIMETHOXYPHENYL) 2 (ETHYLTHIO) 4 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDAZOLE; 5 (2,3 DIMETHOXYPHENYL) 2 (METHYLTHIO) 4 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDAZOLE; 5 (2,4 DIMETHOXYPHENYL) 2 (ETHYLTHIO) 4 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDAZOLE; 5 (2,4 DIMETHOXYPHENYL) 2 (METHYLTHIO) 4 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDAZOLE; 5 (4 METHOXYPHENYL) 2 (METHYLTHIO) 4 (3,4,5 TRIMETHOXYPHENYL) 1H IMIDAZOLE; ALPHA TUBULIN; BETA TUBULIN; CARBONATE DEHYDRATASE IV; COLCHICINE; IMIDAZOLE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL LINE; CELL STRAIN 3T3; CELL STRAIN AGS; CELL STRAIN HT 29; CELL STRAIN MCF 7; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HYDROGEN BOND; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; TUBULIN INHIBITORY ACTIVITY;

DRUG DESIGN; IMIDAZOLES; MICROTUBULES; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 84876667823     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.03.011     Document Type: Article

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