Imidazolone-amide bridges and their effects on tubulin polymerization in cis-locked vinylogous combretastatin-A4 analogues: Synthesis and biological evaluation

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 11, 2011, Pages 3579-3584

  Li, Yao Wu ^b   Liu, Jia ^a   Liu, Na ^a   Shi, Duo ^a   Zhou, Xiao Tian ^a   Lv, Jia Guo ^a   Zhu, Ju ^a   Zheng, Can Hui ^a   Zhou, You Jun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b AIR FORCE GENERAL HOSPITAL   (China)

Author keywords

Antitumor agent; Imidazolone amide; Tubulin polymerization inhibitor

Indexed keywords

2 OXO N 4 TOLYL 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; 2 OXO N META TOLYL 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; 2 OXO N PHENYL 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; ANTINEOPLASTIC AGENT; COLCHICINE; COMBRETASTATIN A4 DERIVATIVE; IMIDAZOLE DERIVATIVE; N (3 AMINO 4 METHOXYPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (3 CHLORO 4 METHYLPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (3 CHLOROPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (3 NITROPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (3,4 DICHLOROPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (3,4 DIMETHOXYPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (3,5 DIMETHYLPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (4 CHLOROPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (4 METHOXY 3 NITROPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (4 METHOXYPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (4 TERT BUTYLPHENYL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; N (NAPHTHALEN 1 YL) 2 OXO 5 (3,4,5 TRIMETHOXYPHENYL) 2,3 DIHYDRO 1H IMIDAZOLE 4 CARBOXAMIDE; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOLECULAR DOCKING; PROTEIN POLYMERIZATION; STRUCTURE ACTIVITY RELATION;

AMIDES; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; HUMANS; IMIDAZOLES; ISOMERISM; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 79957517004     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.068     Document Type: Article

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