Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor δ agonists

Journal of Medicinal Chemistry

Volumn 53, Issue 1, 2010, Pages 77-105

  Epple, Robert ^a   Cow, Christopher ^a   Xie, Yongping ^a   Azimioara, Mihai ^a   Russo, Ross ^a   Wang, Xing ^a   Wityak, John ^a   Karanewsky, Donald S ^a   Tuntland, Tove ^a   Nguyêñ Trân, Vân T B ^a   Ngo, Cara Cuc ^a   Huang, David ^a   Saez, Enrique ^a   Spalding, Tracy ^a   Gerken, Andrea ^a   Iskandar, Maya ^a   Seidel, H Martin ^a   Tian, Shin Shay ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; [4 [4 (6 METHOXYPYRIDIN 3 YL) 5 (4 TRIFLUOROMETHOXYPHENYL) THIAZOL 2 YLMETHOXY] 2 METHYLPHENOXY]ACETIC ACID; MOLECULAR SCAFFOLD; OXAZOLE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PROTEIN KINASE; PYRUVATE DEHYDROGENASE KINASE 4; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DRUG SELECTIVITY; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PROTEIN INDUCTION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG EVALUATION, PRECLINICAL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR STRUCTURE; OXAZOLES; PPAR DELTA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 74849094116     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9007399     Document Type: Article

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