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Volumn 20, Issue 24, 2012, Pages 7160-7166

Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors

(8) Assadieskandar, Amir a Amini, Mohsen a Salehi, Marjan a Sadeghian, Hamid b,c Alimardani, Maliheh c Sakhteman, Amirhossein d Nadri, Hamid d Shafiee, Abbas a

a TEHRAN UNIVERSITY OF MEDICAL SCIENCES (Iran)

b MASHHAD UNIVERSITY OF MEDICAL SCIENCES (Iran)

c MASHHAD UNIVERSITY OF MEDICAL SCIENCES (Iran)

d SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES (Iran)

Author keywords

4,5 Diarylimidazole; Radical scavenging activity; Soybean 15 lipoxygenase (SLO); Structure activity relationship studies

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 4 (4 (DIMETHYLAMINO)PHENYL) 5 (4 METHOXYPHENYL) 1H IMIDAZOLE 2 (3H) THIONE; 4 (4 (METHYLTHIO)PHENYL) 5 PHENYL 1H IMIDAZOLE 2 (3H) THIONE; 4 (4 CHLOROPHENYL) 5 (4 (DIMETHYLAMINO)PHENYL) 1H IMIDAZOLE 2 (3H) THIONE; 4 (4 CHLOROPHENYL) 5 (4 (METHYLTHIO)PHENYL) 1H IMIDAZOLE 2 (3H) THIONE; 4 (4 CHLOROPHENYL) 5 (4 METHOXYPHENYL) 1H IMIDAZOLE 2 (3H) THIONE; 4 (4 CHLOROPHENYL) 5 PHENYL 1H IMIDAZOLE 2 (3H) THIONE; 4 (4 FLUOROPHENYL) 5 (4 (METHYLTHIO)PHENYL) 1H IMIDAZOLE 2 (3H) THIONE; 4 (4 FLUOROPHENYL) 5 (4 METHOXYPHENYL) 1H IMIDAZOLE 2 (3H) THIONE; 4 (4 METHOXYPHENYL) 5 PHENYL 1H IMIDAZOLE 2 (3H) THIONE; 4,5 BIS (4 CHLOROROPHENYL) 1H IMIDAZOLE 2 (3H) THIONE; 4,5 BIS (4 FLUOROPHENYL) 1H IMIDAZOLE 2 (3H) THIONE; 4,5 BIS (4 METHOXYPHENYL) 1H IMIDAZOLE 2 (3H) THIONE; 4,5 DIARYL 1H IMIDAZOLE 2 (3H) THIONE DERIVATIVE; 4,5 DIPHENYL 1H IMIDAZOLE 2 (3H) THIONE; 5 (4 CHLOROPHENYL) 4 (4 METHOXYPHENYL) 2 (METHYLTHIO) 1H IMIDAZOLE; ARACHIDONATE 15 LIPOXYGENASE; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IRON CHELATION; MOLECULAR DOCKING; MOLECULAR MODEL; POLYMERIZATION; PROTEIN METHYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; SCAVENGING SYSTEM; STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; IMIDAZOLES; LIPOXYGENASE INHIBITORS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP;

GLYCINE MAX;

EID: 84870057800 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.09.050 Document Type: Article

Times cited : (31)

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