The regional differences in the contribution of nitric oxide synthase to skin blood flow at forearm and lower leg sites in response to local skin warming

Microvascular Research

Volumn 90, Issue , 2013, Pages 106-111

  Del Pozzi, Andrew T ^a   Carter, Stephen J ^a   Collins, Ann B ^a   Hodges, Gary J ^a  

^a UNIVERSITY OF ALABAMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FOREARM BLOOD FLOW; HEAT TREATMENT; HUMAN; HUMAN EXPERIMENT; LEG BLOOD FLOW; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REST; SKIN BLOOD FLOW; SKIN CONDUCTANCE; SKIN TEMPERATURE; VASODILATATION; WARMING;

ADMINISTRATION, CUTANEOUS; ADULT; BLOOD FLOW VELOCITY; ENZYME INHIBITORS; FEMALE; FOREARM; HEMODYNAMICS; HUMANS; LASER-DOPPLER FLOWMETRY; LEG; MALE; MICRODIALYSIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REGIONAL BLOOD FLOW; SKIN; SKIN TEMPERATURE; TIME FACTORS; VASODILATION; YOUNG ADULT;

EID: 84888427706     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2013.10.003     Document Type: Article

References (45)

1. Black M.A., et al. Exercise prevents age-related decline in nitric-oxide-mediated vasodilator function in cutaneous microvessels. J. Physiol. 2008, 586:3511-3524.
2. Bussell C., Cable N.T. Regional differences in the control of skin blood flow at forearm and calf sites. Med. Sci. Sports Exerc. 2002, 35.
3. Carter S.J., Hodges G.J. Sensory and sympathetic nerve contributions to the cutaneous vasodilator response from a noxious heat stimulus. Exp. Physiol. 2011, 96:1208-1217.
4. Charkoudian N. Influences of female reproductive hormones on sympathetic control of the circulation in humans. Clin. Auton. Res. 2001, 11:295-301.
5. Cross A., et al. Body segment differences in surface area, skin temperature and 3D displacement and the estimation of heat balance during locomotion in hominins. PLoS One 2008, 3:e2464.
6. Green D., et al. Assessment of brachial artery blood flow across the cardiac cycle: retrograde flows during cycle ergometry. J. Appl. Physiol. 2002, 93:361-368.
7. Green D.J., et al. Effect of exercise training on endothelium-derived nitric oxide function in humans. J. Physiol. 2004, 561:1-25.
8. Green D.J., et al. Obligatory role of hyperaemia and shear stress in microvascular adaptation to repeated heating in humans. J. Physiol. 2010, 588:1571-1577.
9. Hodges G.J., Johnson J.M. Adrenergic control of the human cutaneous circulation. Appl. Physiol. Nutr. Metab. 2009, 34:829-839.
10. Hodges G.J., et al. The involvement of nitric oxide in the cutaneous vasoconstrictor response to local cooling in humans. J. Physiol. 2006, 574:849-857.
11. Hodges G.J., et al. The involvement of norepinephrine, neuropeptide Y, and nitric oxide in the cutaneous vasodilator response to local heating in humans. J. Appl. Physiol. 2008, 105:233-240.
12. Hodges G.J., et al. The effect of microdialysis needle trauma on cutaneous vascular responses in humans. J. Appl. Physiol. 2009, 106:1112-1118.
13. Hodges G.J., et al. The involvement of heating rate and vasoconstrictor nerves in the cutaneous vasodilator response to skin warming. Am. J. Physiol. Heart Circ. Physiol. 2009, 296:H51-H56.
14. Hodges G.J., et al. The effect of 48weeks of aerobic exercise training on cutaneous vasodilator function in post-menopausal females. Eur. J. Appl. Physiol. 2010, 108:1259-1267.
15. Holowatz L.A., et al. The human cutaneous circulation as a model of generalized microvascular function. J. Appl. Physiol. 2008, 105:370-372.
16. Houghton B.L., et al. Nitric oxide and noradrenaline contribute to the temperature threshold of the axon reflex response to gradual local heating in human skin. J. Physiol. 2006, 572:811-820.
17. The Cutaneous Circulation 1990, J.M. Johnson (Ed.).
18. Johnson J.M., Proppe D.W. Cardiovascular adjustments to heat stress. Environmental Physiology 1996, vol. I:215-243. Am Physiol Soc, Bethesda, MD.
19. Johnson J.M., et al. Laser-Doppler measurement of skin blood flow: comparison with plethysmography. J. Appl. Physiol. 1984, 56:798-803.
20. Johnson J.M., et al. Regulation of the cutaneous circulation. Fed. Proc. 1986, 45:2841-2850.
21. Kellogg D.L., et al. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J. Appl. Physiol. 1999, 86:1185-1190.
22. Kellogg D.L., et al. Acetylcholine-induced vasodilation is mediated by nitric oxide and prostaglandins in human skin. J. Appl. Physiol. 2005, 98:629-632.
23. Kellogg D.L., et al. Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. Am. J. Physiol. Heart Circ. Physiol. 2008, 295:H123-H129.
24. Kellogg D.L., et al. Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo. J. Physiol. 2008, 586:847-857.
25. Kellogg D.L., et al. Roles of nitric oxide synthase isoforms in cutaneous vasodilation induced by local warming of the skin and whole body heat stress in humans. J. Appl. Physiol. 2009, 107:1438-1444.
26. Minson C.T., et al. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J. Appl. Physiol. 2001, 91:1619-1626.
27. Öberg P.A. Laser-Doppler flowmetry. Crit. Rev. Biomed. Eng. 1990, 18:125-163.
28. Park M.K., Guntheroth W.G. Direct blood pressure measurements in brachial and femoral arteries in children. Circulation 1970, 41:231-237.
29. Pawelczyk J.A., Levine B.D. Heterogeneous responses of human limbs to infused adrenergic agonists: a gravitational effect?. J. Appl. Physiol. 2002, 92(5):2105-2113. (May).
30. Sareen P., et al. Comparison of arm and calf blood pressure. Indian J. Anaesth. 2012, 56:83-85.
31. Stephens D.P., et al. Sympathetic nonnoradrenergic cutaneous vasoconstriction in women is associated with reproductive hormone status. Am. J. Physiol. Heart Circ. Physiol. 2002, 282:H264-H272.
32. Stewart J.M., et al. Local vascular responses affecting blood flow in postural tachycardia syndrome. Am. J. Physiol. Heart Circ. Physiol. 2003, 285:H2749-H2756.
33. Stewart J.M., et al. Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome. Am. J. Physiol. Heart Circ. Physiol. 2007, 293:H2161-H2167.
34. Stewart J.M., et al. Cutaneous constitutive nitric oxide synthase activation in postural tachycardia syndrome with splanchnic hyperemia. Am. J. Physiol. Heart Circ. Physiol. 2011, 301:H704-H711.
35. Taylor W.F., et al. Effect of high local temperature on reflex cutaneous vasodilation. J. Appl. Physiol. 1984, 57:191-196.
36. Tew G.A., et al. Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvasc. Res. 2011, 82(3):326-332.
37. Tew G.A., et al. Reproducibility of cutaneous thermal hyperaemia assessed by laser Doppler flowmetry in young and older adults. Microvasc. Res. 2011, 81:177-182.
38. Tew G.A., et al. Role of sensory nerves in the rapid cutaneous vasodilator response to local heating in young and older endurance-trained and untrained men. Exp. Physiol. 2011, 96:163-170.
39. Tew G.A., et al. Aging and aerobic fitness affect the contribution of noradrenergic sympathetic nerves to the rapid cutaneous vasodilator response to local heating. J. Appl. Physiol. 2011, 110(5):1264-1270.
40. Tew G.A., et al. Endurance exercise training enhances cutaneous microvascular reactivity in post-menopausal women. Microvasc. Res. 2012, 83:223-228.
41. Tew G.A., et al. Exercise training and the control of skin blood flow in older adults. J. Nutr. Health Aging 2012, 16:237-241.
42. Wong B.J. Sensory nerves and nitric oxide contribute to reflex cutaneous vasodilation in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2013, 304:R651-R656.
43. Wong B.J., et al. Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation. J. Appl. Physiol. 2003, 95:504-510.
44. Yamazaki F., Yuge N. Limb-specific differences in the skin vascular responsiveness to adrenergic agonists. J. Appl. Physiol. 2011, 111:170-176.
45. Yamazaki F., et al. Rate dependency and role of nitric oxide in the vascular response to direct cooling in human skin. J. Appl. Physiol. 2006, 100:42-50.