Cutaneous constitutive nitric oxide synthase activation in postural tachycardia syndrome with splanchnic hyperemia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 3, 2011, Pages

  Stewart, Julian M ^a   Nafday, Abhinav ^a   Ocon, Anthony J ^a   Terilli, Courtney ^a   Medow, Marvin S ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Acetylcholine; Cutaneous blood flow; Laser doppler flowmetry; Nitric oxide synthase isoforms

Indexed keywords

ACETYLCHOLINE; AMINOGUANIDINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; RINGER SOLUTION;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONDUCTANCE; CONTROLLED STUDY; DIALYSIS CATHETER; DOSE RESPONSE; FEMALE; HEATING; HUMAN; HYPEREMIA; LASER DOPPLER FLOWMETRY; MALE; MICRODIALYSIS; MICROVASCULARIZATION; NERVE CELL; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; PRIORITY JOURNAL; SKIN BLOOD FLOW; SKIN BLOOD VESSEL; SPLANCHNIC HYPEREMIA; STIMULUS RESPONSE;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; BLOOD FLOW VELOCITY; CASE-CONTROL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUMANS; HYPEREMIA; LASER-DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; MICRODIALYSIS; MICROVESSELS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME; REGIONAL BLOOD FLOW; SKIN; SKIN TEMPERATURE; SPLANCHNIC CIRCULATION; VASODILATION; VASODILATOR AGENTS; YOUNG ADULT;

EID: 80052330344     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00171.2011     Document Type: Article

References (56)

1. Adkisson EJ, Casey DP, Beck DT, Gurovich AN, Martin JS, Braith RW. Central, peripheral and resistance arterial reactivity: fluctuates during the phases of the menstrual cycle. Exp Biol Med (Maywood) 235: 111-118, 2010.
2. Arbeille PP, Besnard SS, Kerbeci PP, Mohty DM. Portal vein crosssectional area and flow and orthostatic tolerance: a 90-day bed rest study. J Appl Physiol 99: 1853-1857, 2005.
3. Baudouin JE, Tachon P. Constitutive nitric oxide synthase is present in normal human keratinocytes. J Invest Dermatol 106: 428-431, 1996.
4. Bonyhay I, Freeman R. Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome. Circulation 110: 3193-3198, 2004.
5. Boutsiouki P, Georgiou S, Clough GF. Recovery of nitric oxide from acetylcholine-mediated vasodilatation in human skin in vivo. Microcirculation 11: 249-259, 2004.
6. Danson EJ, Mankia KS, Golding S, Dawson T, Everatt L, Cai S, Channon KM, Paterson DJ. Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one nNOS allele. J Physiol 558: 963-974, 2004.
7. Dawson D, Lygate CA, Zhang MH, Hulbert K, Neubauer S, Casadei B. nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction. Circulation 112: 3729-3737, 2005.
8. Forstermann U, Boissel JP, Kleinert H. Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J 12: 773-790, 1998.
9. Fu Q, VanGundy TB, Shibata S, Auchus RJ, Williams GH, Levine BD. Menstrual cycle affects renal-adrenal and hemodynamic responses during prolonged standing in the postural orthostatic tachycardia syndrome. Hypertension 56: 82-90, 2010.
10. Garland EM, Winker R, Williams SM, Jiang L, Stanton K, Byrne DW, Biaggioni I, Cascorbi I, Phillips JA 3rd, Harris PA, Rudiger H, Robertson D. Endothelial NO synthase polymorphisms and postural tachycardia syndrome. Hypertension 46: 1103-1110, 2005.
11. Greenberg SS, Cantor E, Diecke FP, Peevy K, Tanaka TP. Cyclic GMP modulates release of norepinephrine from adrenergic nerves innervating canine arteries. Am J Hypertens 4: 173-176, 1991.
12. Greenfield AD, Whitney RJ, Whitney RJ. Methods for the investigation of peripheral blood flow. Br Med Bull 19: 101-109, 1963.
13. Hatanaka Y, Hobara N, Honghua J, Akiyama S, Nawa H, Kobayashi Y, Takayama F, Gomita Y, Kawasaki H. Neuronal nitric-oxide synthase inhibition facilitates adrenergic neurotransmission in rat mesenteric resistance arteries. J Pharmacol Exp Ther 316: 490-497, 2006.
14. Holowatz LA, Thompson-Torgerson CS, Kenney WL. The human cutaneous circulation as a model of generalized microvascular function. J Appl Physiol 105: 370-372, 2008.
15. Huang H, Martasek P, Roman LJ, Silverman RB. Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases. J Med Chem 43: 2938-2945, 2000.
16. Jacob G, Costa F, Shannon JR, Robertson RM, Wathen M, Stein M, Biaggioni I, Ertl A, Black B, Robertson D. The neuropathic postural tachycardia syndrome. N Engl J Med 343: 1008-1014, 2000.
17. Jacob G, Shannon JR, Black B, Biaggioni I, Mosqueda-Garcia R, Robertson RM, Robertson D. Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia. Circulation 96: 575-580, 1997.
18. Jansson L, Carlsson PO, Bodin B, Andersson A, Kallskog O. Neuronal nitric oxide synthase and splanchnic blood flow in anaesthetized rats. Acta Physiol Scand 183: 257-262, 2005.
19. Johnson JM, Taylor WF, Shepherd AP, Park MK. Laser-Doppler measurement of skin blood flow: comparison with plethysmography. J Appl Physiol 56: 798-803, 1984.
20. Kavdia M, Popel AS. Contribution of nNOS-and eNOS-derived NO to microvascular smooth muscle NO exposure. J Appl Physiol 97: 293-301, 2004.
21. Kellogg DL Jr, Liu Y, Kosiba IF, O'Donnell D. Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol 86: 1185-1190, 1999.
22. Kellogg DL Jr, Zhao JL, Wu Y. Roles of nitric oxide synthase isoforms in cutaneous vasodilation induced by local warming of the skin and whole body heat stress in humans. J Appl Physiol 107: 1438-1444, 2009.
23. Kolo LL, Westfall TC, Macarthur H. Nitric oxide decreases the biological activity of norepinephrine resulting in altered vascular tone in the rat mesenteric arterial bed. Am J Physiol Heart Circ Physiol 286: H296-H303, 2004.
24. Lee K, Mack GW. Role of nitric oxide in methacholine-induced sweating and vasodilation in human skin. J Appl Physiol 100: 1355-1360, 2006.
25. Liu JL, Murakami H, Zucker IH. Angiotensin II-nitric oxide interaction on sympathetic outflow in conscious rabbits. Circ Res 82: 496-502, 1998.
26. Lobachik VI, Chupushtanov SA, Pishchulina GI. Mechanisms of the decrease in human postural stability during prolonged head-down tilt. J Gravit Physiol 11: 139-140, 2004.
27. Low PA. Autonomic neuropathies. Curr Opin Neurol 15: 605-609, 2002.
28. Low PA, Opfer-Gehrking TL, Textor SC, Benarroch EE, Shen WK, Schondorf R, Suarez GA, Rummans TA. Postural tachycardia syndrome (POTS). Neurology 45: S19-S25, 1995.
29. Minson CT, Berry LT, Joyner MJ. Nitric oxide and neurally mediated regulation of skin blood flow during local heating. J Appl Physiol 91: 1619-1626, 2001.
30. Mustafa HI, Garland EM, Biaggioni I, Black BK, Dupont WD, Robertson D, Raj SR. Abnormalities of angiotensin regulation in postural tachycardia syndrome. Heart Rhythm 8: 422-428, 2011.
31. Okamura T, Ayajiki K, Uchiyama M, Uehara M, Toda N. Neurogenic vasodilatation of canine isolated small labial arteries. J Pharmacol Exp Ther 288: 1031-1036, 1999.
32. Overton JM, Tipton CM. Effect of hindlimb suspension on cardiovascular responses to sympathomimetics and lower body negative pressure. J Appl Physiol 68: 355-362, 1990.
33. Parsons RL, Locknar SA, Young BA, Hoard JL, Hoover DB. Presence and co-localization of vasoactive intestinal polypeptide with neuronal nitric oxide synthase in cells and nerve fibers within guinea pig intrinsic cardiac ganglia and cardiac tissue. Cell Tissue Res 323: 197-209, 2006.
34. Patel KP, Zhang K, Zucker IH, Krukoff TL. Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brainstem of rats in heart failure. Brain Res 734: 109-115, 1996.
35. Rockey DC, Shah V. Nitric oxide biology and the liver: report of an AASLD research workshop. Hepatology 39: 250-257, 2004.
36. Sandroni P, Opfer-Gehrking TL, McPhee BR, Low PA. Postural tachycardia syndrome: clinical features and follow-up study. Mayo Clin Proc 74: 1106-1110, 1999.
37. Schmidt HH, Lohmann SM, Walter U. The nitric oxide and cGMP signal transduction system: regulation and mechanism of action. Biochim Biophys Acta 1178: 153-175, 1993.
38. Schondorf R, Low PA. Idiopathic postural orthostatic tachycardia syndrome: an attenuated form of acute pandysautonomia? Neurology 43: 132-137, 1993.
39. Seddon M, Melikian N, Dworakowski R, Shabeeh H, Jiang B, Byrne J, Casadei B, Chowienczyk P, Shah AM. Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo. Circulation 119: 2656-2662, 2009.
40. Seddon MD, Chowienczyk PJ, Brett SE, Casadei B, Shah AM. Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo. Circulation 117: 1991-1996, 2008.
41. Shibasaki M, Wilson TE, Cui J, Crandall CG. Acetylcholine released from cholinergic nerves contributes to cutaneous vasodilation during heat stress. J Appl Physiol 93: 1947-1951, 2002.
42. Stewart JM. Pooling in chronic orthostatic intolerance: arterial vasoconstrictive but not venous compliance defects. Circulation 105: 2274-2281, 2002.
43. Stewart JM. Microvascular filtration is increased in postural tachycardia syndrome. Circulation 107: 2816-2822, 2003.
44. Stewart JM, Glover JL, Medow MS. Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume. Clin Sci (Lond) 110: 255-263, 2006.
45. Stewart JM, Medow MS, Glover JL, Montgomery LD. Persistent splanchnic hyperemia during upright tilt in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 290: H665-H673, 2006.
46. Stewart JM, Medow MS, Minson CT, Taneja I. Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 293: H2161-H2167, 2007.
47. Stewart JM, Medow MS, Montgomery LD. Local vascular responses affecting blood flow in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 285: H2749-H2756, 2003.
48. Stewart JM, Montgomery LD. Regional blood volume and peripheral blood flow in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 287: H1319-H1327, 2004.
49. Stewart JM, Ocon AJ, Clarke D, Taneja I, Medow MS. Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome. Hypertension 53: 767-774, 2009.
50. Stewart JM, Taneja I, Glover J, Medow MS. Angiotensin II type 1 receptor blockade corrects cutaneous nitric oxide deficit in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol 294: H466-H473, 2008.
51. Streeten DH. Pathogenesis of hyperadrenergic orthostatic hypotension. Evidence of disordered venous innervation exclusively in the lower limbs. J Clin Invest 86: 1582-1588, 1990.
52. Streeten DH, Anderson GH Jr, Richardson R, Thomas FD. Abnormal orthostatic changes in blood pressure and heart rate in subjects with intact sympathetic nervous function: evidence for excessive venous pooling. J Lab Clin Med 111: 326-335, 1988.
53. Tarasova O, Borovik A, Tsvirkoun D, Lebedev V, Steeves J, Krassioukov A. Orthostatic response in rats after hindlimb unloading: effect of transcranial electrical stimulation. Aviat Space Environ Med 78: 1023-1028, 2007.
54. Toda N, Okamura T. The pharmacology of nitric oxide in the peripheral nervous system of blood vessels. Pharmacol Rev 55: 271-324, 2003.
55. Vaziri ND, Ding Y, Sangha DS, Purdy RE. Upregulation of NOS by simulated microgravity, potential cause of orthostatic intolerance. J Appl Physiol 89: 338-344, 2000.
56. Wolff DJ, Lubeskie A. Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthase. Arch Biochem Biophys 316: 290-301, 1995.