Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn 23 Iowa mutation

Biochemical Journal

Volumn 456, Issue 3, 2013, Pages 347-360

  Fossati, Silvia ^a   Todd, Krysti ^a   Sotolongo, Krystal ^a   Ghiso, Jorge ^a   Rostagno, Agueda ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebral amyloid angiopathy; Familial Alzheimer's disease; Methazolamide; Mitochondrial dysfunction; Post translational modification

Indexed keywords

AMYLOID BETA PROTEIN; CYTOCHROME C; ISOASPARTIC ACID; METHAZOLAMIDE; CARBONATE DEHYDRATASE INHIBITOR;

APOPTOSIS; ARTICLE; BETA SHEET; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DNA FRAGMENTATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; IOWA MUTATION; MICROVASCULAR ENDOTHELIAL CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MUTATION; NERVE CELL; NEUROPROTECTION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; AMINO ACID SUBSTITUTION; ANTAGONISTS AND INHIBITORS; CELL CULTURE; GENETICS; METABOLISM; MISSENSE MUTATION; MITOCHONDRION; PATHOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEINOSIS;

AMINO ACID SUBSTITUTION; AMYLOID BETA-PEPTIDES; APOPTOSIS; CARBONIC ANHYDRASE INHIBITORS; CELLS, CULTURED; CYTOCHROMES C; CYTOPLASM; HUMANS; ISOASPARTIC ACID; METHAZOLAMIDE; MITOCHONDRIA; MUTATION, MISSENSE; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY;

EID: 84888422029     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130652     Document Type: Article

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