ERK5 regulates invasiveness of osteosarcoma by inducing MMP-9

Journal of Orthopaedic Research

Volumn 30, Issue 7, 2012, Pages 1040-1044

  Kim, Sang Min ^a   Lee, Hyewon ^a   Park, Youn Soo ^a   Lee, Youbin ^a   Seo, Sung Wook ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

cellular invasion; ERK5; MMP 9; osteosarcoma

Indexed keywords

MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 7; SMALL INTERFERING RNA;

ARTICLE; CANCER INVASION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REPRESSION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; OSTEOSARCOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ZYMOGRAPHY;

BONE NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE 7; NEOPLASM INVASIVENESS; OSTEOSARCOMA; RNA, SMALL INTERFERING;

EID: 84861095929     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22025     Document Type: Article

References (20)

1. Bacci G, Longhi A, Bertoni F, et al. 2006. Bone metastases in osteosarcoma patients treated with neoadjuvant or adjuvant chemotherapy: The Rizzoli experience in 52 patients. Acta Orthop 77: 938-943.
2. Ferrari S, Palmerini E,. 2007. Adjuvant and neoadjuvant combination chemotherapy for osteogenic sarcoma. Curr Opin Oncol 19: 341-346.
3. Rosen G, Caparros B, Huvos AG, et al. 1982. Preoperative chemotherapy for osteogenic sarcoma: Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 49: 1221-1230.
4. Zhang P, Yang Y, Zweidler-McKay PA, et al. 2008. Critical role of notch signaling in osteosarcoma invasion and metastasis. Clin Cancer Res 14: 2962-2969.
5. English JM, Vanderbilt CA,., Xu S, et al. 1995. Isolation of MEK5 and differential expression of alternatively spliced forms. J Biol Chem 270: 28897-28902.
6. Kato Y, Kravchenko VV, Tapping RI, et al. 1997. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J 16: 7054-7066.
7. McCracken SR, Ramsay A, Heer R, et al. 2008. Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer. Oncogene 27: 2978-2988.
8. Montero JC, Ocana A, Abad M, et al. 2009. Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target. PLoS One 4: e5565.
9. Mehta PB, Jenkins BL, McCarthy L, et al. 2003. MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. Oncogene 22: 1381-1389.
10. Lennartsson J, Burovic F, Witek B, et al. 2010. Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis. Cell Signal 22: 955-960.
11. Sawhney RS, Liu W, Brattain MG,. 2009. A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling. J Cell Physiol 219: 152-161.
12. Ray JM, Stetler-Stevenson WG,. 1994. The role of matrix metalloproteases and their inhibitors in tumour invasion, metastasis and angiogenesis. Eur Respir J 7: 2062-2072.
13. Liotta LA, Steeg PS, Stetler-Stevenson WG,. 1991. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation. Cell 64: 327-336.
14. Tsuchiya Y, Endo Y, Sato H, et al. 1994. Expression of type-IV collagenases in human tumor cell lines that can form liver colonies in chick embryos. Int J Cancer 56: 46-51.
15. Bianco FJ Jr, Gervasi DC, Tiguert R, et al. 1998. Matrix metalloproteinase-9 expression in bladder washes from bladder cancer patients predicts pathological stage and grade. Clin Cancer Res 4: 3011-3016.
16. Davies B, Waxman J, Wasan H, et al. 1993. Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion. Cancer Res 53: 5365-5369.
17. Grignon DJ, Sakr W, Toth M, et al. 1996. High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer. Cancer Res 56: 1654-1659.
18. Hong S, Park KK, Magae J, et al. 2005. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: Inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. J Biol Chem 280: 25202-25209.
19. Sato H, Seiki M,. 1993. Regulatory mechanism of 92kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 8: 395-405.
20. Bjornland K, Flatmark K, Pettersen S, et al. 2005. Matrix metalloproteinases participate in osteosarcoma invasion. J Surg Res 127: 151-156.