Protective role of melatonin and taurine against carbamazepine-induced toxicity in freshly isolated rat hepatocytes;Rol protector de la melatonina y taurina contra la toxicidad inducida por la carbamazepina en hepatocitos de rata recién aislados

International Journal of Morphology

Volumn 31, Issue 3, 2013, Pages 1081-1089

  Eghbal, Mohammad Ali ^a,b   Taziki, Shohreh ^a,b   Sattari, Mohammad Reza ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Carbamazepine; Hepatotoxicity; Melatonin; Oxidative stress; Taurine

Indexed keywords

EID: 84888403892     PISSN: 07179367     EISSN: 07179502     Source Type: Journal    
DOI: 10.4067/S0717-95022013000300049     Document Type: Article

References (32)

1. Ahmed, S. N. & Siddiqi, Z. A. Antiepileptic drugs and liver disease. Seizure, 15(3): 156-64, 2006.
2. Anoush, M.; Eghbal, M. A.; Fathiazad, F.; Hamzeiy, H. & Kouzehkonani, N. S. The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion. Pak. J. Biol. Sci., 12(10): 765-71, 2009.
3. Aycicek, A. & Iscan, A. The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children. Eur. Neurol., 57(2): 65-9, 2007.
4. Bavdekar, S. B.; Muranjan, M. N.; Gogtay, N. J.; Kantharia, V. & Kshirsagar, N. A. Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment. Ann. Pharmacother., 38(10): 1648-50, 2004.
5. Benzie, I. F. Lipid peroxidation: a review of causes, consequences, measurement and dietary influences. Int. J. Food Sci. Nutr., 47(3): 233-61, 1996.
6. Eghbal, M. A.; Pennefather, P. S. & O'Brien, P. J. H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation. Toxicology, 203(1-3): 69-76, 2004.
7. El Idrissi, A.; Messing, J.; Scalia, J. & Trenkner, E. Prevention of epileptic seizures by taurine. Adv. Exp. Med. Biol., 526: 515-25, 2003.
8. Forbes, G. M.; Jeffrey, G. P.; Shilkin, K. B. & Reed, W. D. Carbamazepine hepatotoxicity: another cause of the vanishing bile duct syndrome. Gastroenterology, 102(4 Pt. 1): 1385-8, 1992.
9. Gaull, G. E.; Pasantes-Morales, H. & Wright, C. E. Taurine in human nutrition: overview. Prog. Clin. Biol. Res., 179: 3-21, 1985.
10. Heidari, R.; Babaei, H. & Eghbal, M. A. Ameliorative effects of taurine against methimazole-induced cytotoxicity in isolated rat hepatocytes. Sci. Pharm., 80(4): 987-99, 2012.
11. Hong, R. T.; Xu, J. M. & Mei, Q. Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats. World J. Gastroenterol., 15(12): 1452-8, 2009.
12. Kalapos, M. P. Carbamazepine-provoked hepatotoxicity and possible aetiopathological role of glutathione in the events. Retrospective review of old data and call for new investigation. Adverse Drug React. Toxicol. Rev., 21(3): 123-41, 2002.
13. Kleinman, W. A. & Richie, J. P. Jr. Status of glutathione and other thiols and disulfides in human plasma. Biochem. Pharmacol., 60(1): 19-29, 2000.
14. Lu, S. C. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J., 13(10): 1169-83, 1999.
15. Madan, A.; Graham, R. A.; Carroll, K. M.; Mudra, D. R.; Burton, L. A.; Krueger, L. A.; et al. Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab. Dispos., 31(4): 421-31, 2003.
16. Madden, S.; Maggs, J. L. & Park, B. K. Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s). Drug Metab. Dispos., 24(4): 469-79, 1996.
17. Martín, M.; Macías, M.; León, J.; Escames, G.; Khaldy, H. & Acuña-Castroviejo, D. Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria. Int. J. Biochem. Cell Biol., 34(4): 348-57, 2002.
18. Moldeus, P.; Hogberg, J. & Orrenius, S. Isolation and use of liver cells. Methods Enzymol., 52: 60-71, 1978.
19. Nakashima, T.; Taniko, T. & Kuriyama, K. Therapeutic effect of taurine administration on carbon tetrachloride-induced hepatic injury. Jpn. J. Pharmacol., 32(4): 583-9, 1982.
20. Nandhini, A. T.; Thirunavukkarasu, V.; Ravichandran, M. K. & Anuradha, C. V. Effect of taurine on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats. Singapore Med. J., 46(2): 82-7, 2005.
21. Pan, M.; Song, Y. L.; Xu, J. M. & Gan, H. Z. Melatonin ameliorates nonalcoholic fatty liver induced by high-fat diet in rats. J. Pineal Res., 41(1): 79-84, 2006.
22. Parmar, P.; Limson, J.; Nyokong, T. & Daya, S. Melatonin protects against copper-mediated free radical damage. J. Pineal Res., 32(4): 237-42, 2002.
23. Rahman, I.; Kode, A. & Biswas, S. K. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat. Protoc., 1(6): 3159-65, 2006.
24. Riener, C. K.; Kada, G. & Gruber, H. J. Quick measurement of protein sulfhydryls with Ellman's reagent and with 4, 4'-dithiodipyridine. Anal. Bioanal. Chem., 373(4-5): 266-76, 2002.
25. Santos, N. A.; Medina, W. S.; Martins, N. M.; Rodrigues, M. A.; Curti, C. & Santos, A. C. Involvement of oxidative stress in the hepatotoxicity induced by aromatic antiepileptic drugs. Toxicol. In Vitro, 22(8): 1820-4, 2008a.
26. Santos, N. A.; Medina, W. S.; Martins, N. M.; Mingatto, F. E.; Curti, C. & Santos, A. C. Aromatic antiepileptic drugs and mitochondrial toxicity: effects on mitochondria isolated from rat liver. Toxicol. In Vitro, 22(5): 1143-52, 2008b.
27. Schaffer, S. W.; Azuma, J. & Mozaffari, M. Role of antioxidant activity of taurine in diabetes. Can. J. Physiol. Pharmacol., 87(2): 91-9, 2009.
28. Shear, N. H. & Spielberg, S. P. Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. J. Clin. Invest., 82(6): 1826-32, 1988.
29. Smith, M. T.; Thor, H.; Hartizell, P. & Orrenius, S. The measurement of lipid peroxidation in isolated hepatocytes. Biochem. Pharmacol., 31(1): 19-26, 1982.
30. Trachtman, H.; Del Pizzo, R.; Futterweit, S.; Levine, D.; Rao, P. S.; Valderrama, E.; et al. Taurine attenuates renal disease in chronic puromycin aminonucleoside nephropathy. Am. J. Physiol., 262(1 Pt. 2): F117-23, 1992.
31. van Gelder, N. M. Neuronal discharge hypersynchrony and the intracranial water balance in relation to glutamic acid and taurine redistribution: migraine and epilepsy. Prog. Clin. Biol. Res., 351: 1-20, 1990.
32. Waters, E.; Wang, J. H.; Redmond, H. P.; Wu, Q. D.; Kay, E. & Bouchier-Hayes, D. Role of taurine in preventing acetaminophen-induced hepatic injury in the rat. Am. J. Physiol. Gastrointest. Liver Physiol., 280(6): G1274-9., 2001.