Involvement of oxidative stress in the hepatotoxicity induced by aromatic antiepileptic drugs

Toxicology in Vitro

Volumn 22, Issue 8, 2008, Pages 1820-1824

  Santos, N A G ^a   Medina, W S G ^a   Martins, N M ^a   Rodrigues, M A Carvalho ^a   Curti, C ^a   Santos, A C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Arene oxides; Aromatic antiepileptic drugs; Bioactivation; Carbamazepine; Hepatotoxicity; Mitochondria; Oxidative stress; Phenobarbital; Phenytoin

Indexed keywords

CARBAMAZEPINE; CARDIOLIPIN; DRUG METABOLITE; MALONALDEHYDE; PHENOBARBITAL; PHENYTOIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; LIVER MICROSOME; LIVER TOXICITY; MALE; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; RAT;

ANIMALS; ANTICONVULSANTS; CARBAMAZEPINE; CARDIOLIPINS; LIVER; MALE; MALONDIALDEHYDE; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHENOBARBITAL; PHENYTOIN; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; TOXICITY TESTS;

RATTUS;

EID: 55149122213     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.08.004     Document Type: Article

References (36)

1. Ahmed S.N., and Siddiqi Z.A. Antiepileptic drugs and liver disease. Seizure 15 (2006) 156-164
2. Aycicek A., and Iscan A. The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children. European Neurology 57 (2007) 65-69
3. Bavdekar S.B., Muranjan M.N., Gogtay N.J., Kantharia V., and Kshirsagar N.A. Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment. The Annals of Pharmacotherapy 38 (2004) 1648-1650
4. Boelsterli U.A., and Lim P.L. Mitochondrial abnormalities - a link to idiosyncratic drug hepatotoxicity?. Toxicology and Applied Pharmacology 220 (2007) 92-107
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 (1976) 248-254
6. Buege J.A., and Aust S.D. Microsomal lipid peroxidation. Methods in Enzymology 52 (1978) 302-310
7. Chang T.K.H., and Abbott F.S. Oxidative stress as a mechanism of valproic acid-associated hepatotoxicity. Drug Metabolism Reviews 38 (2006) 627-639
8. Fariss M.W., Chan C.B., Patel M., Van Houten B., and Orrenius S. Role of mitochondria in toxic oxidative stress. Molecular Interventions 5 (2005) 94-111
9. Gallet P.F., Maftah A., Petit J.M., Denis-Gay M., and Julien R. Direct cardiolipin assay in yeast using the red fluorescence emission of 10-N-nonyl acridine orange. European Journal of Biochemistry/FEBS 15 (1995) 113-119
10. George J., and Farrell G.C. Anticonvulsivant hepatotoxicity. In: Farrell G.C. (Ed). Drug-induced Liver Disease (1994), Edinburgh, Churchill Livingstone, London 143-144
11. Grattagliano I., Vendemiale G., Sabbá C., Buonamico P., and Altomare E. Oxidation of circulating proteins in alcoholics: role of acetaldehyde and xantine oxidase. Journal of Hepatology 25 (1996) 28-36
12. Hauff K.D., and Hatch G.M. Cardiolipin metabolism and Barth syndrome. Progress in Lipid Research 45 (2006) 91-101
13. Hussaini S.H., and Farrington E.A. Idiosyncratic drug-induced liver injury: an overview. Expert Opinion on Drug Safety 6 (2007) 673-684
14. Jaeschke H. Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?. Toxicological Sciences 97 (2007) 1-3
15. Jones D.P. Radical-free biology of oxidative stress. American Journal of Physiology. Cell Physiology (2008) 10.1152/ajpcell.00283.2008
16. Kalapos M.P. Carbamazepine-provoked hepatotoxicity and possible aetiopathological role of glutathione in the events. Retrospective review of old data and call for new investigation. Adverse Drug Reactions and Toxicological Reviews 21 (2002) 123-141
17. Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nature Reviews. Drug Discovery 4 (2005) 489-499
18. Kass G.E. Mitochondrial involvement in drug-induced hepatic injury. Chemical Biological Interactions 163 (2006) 145-159
19. Madden S., Maggs J.L., and Park B.K. Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s). Drug Metabolism and Disposition 24 (1996) 469-479
20. Malhi H., Gores G.J., and Lemasters J.J. Apoptosis and necrosis in the liver: a tale of two deaths?. Hepatology 43 (2006) S31-44
21. Martin C.N., and Garner R.C. The identification and assessment of covalent binding in vitro and in vivo. In: Snell K., and Mullock B. (Eds). Biochemical Toxicology: A Practical Approach (1987), IRL Press, Oxford 109-126
22. Nasreddine W., and Beydoun A. Oxcarbazepine in neuropathic pain. Expert Opinion on Investigational Drugs 16 (2007) 1615-1625
23. Neuman M.G., Malkiewicz I.M., and Shear N.H. A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes. Clinical Biochemistry 33 (2000) 517-524
24. Nitti M., Pronzato M.A., Marinari U.M., and Domenicotti C. PKC signaling in oxidative hepatic damage. Molecular Aspects of Medicine 29 (2008) 36-42
25. Park B.K., Kitteringham N.R., Maggs J.L., Pirmohamed M., and Williams D.P. The role of metabolic activation in drug-induced hepatotoxicity. Annual Review of Pharmacology and Toxicology 45 (2005) 177-202
26. Pedersen P.L., Grenawalt J.W., Reynafarje B., Hullihen J., Decker G.L., Soper J.W., and Bustamente E. Preparation and characterization of mitochondria and submitochondrial particles of rat liver-derived tissues. Methods in Cell Biology 20 (1978) 411-481
27. Petit J.M., Maftah A., Ratinaud M.H., and Julien R. 10-N-nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria. European Journal of Biochemistry 209 (1992) 267-273
28. Roberts C., Harvey M.T., May M.E., Valdovinos M.G., Patterson T.G., Couppis M.H., and Kennedy C.H. Varied effects of conventional antiepileptics on responding maintained by negative versus positive reinforcement. Physiology and Behavior 93 (2008) 612-621
29. Roy D., and Snodgrass W.R. Phenytoin metabolic activation: role of cytochrome P-450, glutathione, age, and sex in rats and mice. Research Communications in Chemical Pathology and Pharmacology 59 (1988) 173-190
30. Santos N.A.G., Medina W.S.G., Martins N.M., Mingatto F.E., Curti C., and Santos A.C. Aromatic antiepileptic drugs and mitochondrial toxicity: effects on mitochondria isolated from rat liver. Toxicology in Vitro 22 (2008) 1143-1152
31. Shear N.H., and Spielberg S.P. Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. Journal of Clinical Investigations 82 (1988) 1826-1832
32. Spielberg S.P., Gordon G.B., Blake D.A., Mellits E.D., and Bross D.S. Anticonvulsant toxicity in vitro: possible role of arene oxides. Journal of Pharmacology and Experimental Therapeutics 217 (1981) 386-389
33. Tietze F. Enzimatic method for quantitative determination of nanogram amounts of total and oxidized gluthathione: applications to mammalian blood and others tissues. Analytical Biochemistry 27 (1969) 502-522
34. Walia K.S., Khan E.A., Ko D.H., Raza S.S., and Khan Y.N. Side effects of antiepileptics - a review. Pain practice. The Official Journal of World Institute of Pain 4 (2004) 194-203
35. Zaccara G., Franciotta D., and Perucca E. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia 48 (2007) 1223-1244
36. Zwanzger P., Eser D., and Rupprecht R. Anticonvulsants in the treatment of anxiety - an alternative treatment option?. Der Nervenarzt 78 (2007) 1274-1282