Aromatic antiepileptic drugs and mitochondrial toxicity: Effects on mitochondria isolated from rat liver

Toxicology in Vitro

Volumn 22, Issue 5, 2008, Pages 1143-1152

  Santos, N A G ^a   Medina, W S G ^a   Martins, N M ^a   Mingatto, F E ^b   Curti, C ^a   Santos, A C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Arene oxides; Aromatic antiepileptic drugs; Carbamazepine; Hepatotoxicity; Mitochondria; Phenobarbital; Phenytoin

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTICONVULSIVE AGENT; CALCIUM ION; CARBAMAZEPINE; PHENOBARBITAL; PHENYTOIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL RESPIRATION; CELL SWELLING; CONTROLLED STUDY; CYTOTOXICITY; ENZYME SYNTHESIS; IN VITRO STUDY; LIVER MICROSOME; LIVER TOXICITY; MALE; MEMBRANE POTENTIAL; METABOLITE; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; NONHUMAN; PATHOGENESIS; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTICONVULSANTS; CALCIUM; CALCIUM SIGNALING; CARBAMAZEPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; OXYGEN CONSUMPTION; PHENOBARBITAL; PHENYTOIN; RATS; RATS, WISTAR;

MURINAE; RATTUS;

EID: 44749089877     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.03.004     Document Type: Article

References (33)

1. Ahmed S.N., and Siddiqi Z.A. Antiepileptic drugs and liver disease. Seizure 15 (2006) 156-164
2. Bavdekar S.B., Muranjan M.N., Gogtay N.J., Kantharia V., and Kshirsagar N.A. Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment. The Annals of Pharmacotherapy 38 (2004) 1648-1650
3. Boelsterli U.A., and Lim P.L. Mitochondrial abnormalities - a link to idiosyncratic drug hepatotoxicity?. Toxicology and Applied Pharmacology 220 (2007) 92-107
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 (1976) 248-254
5. Bu H.Z., Kang P., Deese A.J., Zhao P., and Pool W.F. Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine. Drug Metabolism and Disposition 33 (2005) 1920-1924
6. Cain. K., Skilleter, D.N., 1987. Preparation and use of mitochondria in toxicological research. In: Snell, K., Mullock, B. (Eds.), Biochemical Toxicology - A Practical Approach. IRL Press, Oxford, pp. 217-254.
7. Chance B., and Williams G.R. The respiratory chain and oxidative phosphorylation. Advances in Enzymology and Related Subjects of Biochemistry 17 (1956) 65-134
8. Cognato G.D., Bruno A.N., da Silva R.S., Bogo M.R., Sarkis J.J., and Bonan C.D. Antiepileptic Drugs Prevent Changes Induced by Pilocarpine Model of Epilepsy in Brain Ecto-Nucleotidases. Neurochemical Research (2007) 10.1007/s11064-006-9272-y
9. Coon K.D., Valla J., Szelinger S., Schneider L.E., Niedzielko T.L., Brown K.M., Pearson J.V., Halperin R., Dunckley T., Papassotiropoulos A., Caselli R.J., Reiman E.M., and Stephan D.A. Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing. Mitochondrion 6 (2006) 194-210
10. Dwivedi R., Gogtay N., Kharkar V., Amladi S., and Kshirsagar N. In-vitro lymphocyte toxicity to a phenytoin metabolite in phenytoin induced cutaneous adverse drug eruptions. Indian Journal of Dermatology, Venereology and Leprology 70 (2004) 217-220
11. Eisenberg E., River Y., Shifrin A., and Krivoy N. Antiepileptic drugs in the treatment of neuropathic pain. Drugs 67 (2007) 1265-1289
12. Emaus R.K., Grunwald R., and Lemasters J.J. Rhodamine-123 as a probe of transmembrane potential in isolated rat-liver mitochondria - spectral and metabolic properties. Biochimica et Biophysica Acta 850 (1986) 436-448
13. Farrell G.C. Liver disease caused by drugs, anesthetics, and toxins. Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management (2002), Elsevier, Philadelphia 1411-1415
14. George J., and Farrell G.C. Anticonvulsivant hepatotoxicity. Drug-induced Liver Disease (1994), Edinburgh: Churchill Livingstone, London 143-144
15. Kalapos M.P. Carbamazepine-provoked hepatotoxicity and possible aetiopathological role of glutathione in the events. Retrospective review of old data and call for new investigation. Adverse Drug Reactions and Toxicological Reviews 21 (2002) 123-141
16. Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nature Reviews. Drug Discovery. 4 (2005) 489-499
17. Kass G.E. Mitochondrial involvement in drug-induced hepatic injury. Chemical Biological Interactions 163 (2006) 145-159
18. Kaufman K.R. Carbamazepine, hepatotoxicity, organic solvents, and paints. Seizure 8 (1999) 250-252
19. +2 is dependent on mitochondrial-generated reactive oxygen species. FEBS Letters 378 (1996) 150-152
20. Madden S., Maggs J.L., and Park B.K. Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s). Drug Metabolism and Disposition 24 (1996) 469-479
21. Martin C.N., and Garner R.C. The identification and assessment of covalent binding in vitro and in vivo. In: Snell K., and Mullock B. (Eds). Biochemical Toxicology: A Practical Approach (1987), IRL Press, Oxford 109-126
22. Nasreddine W., and Beydoun A. Oxcarbazepine in neuropathic pain. Expert Opinion on Investigational Drugs 16 (2007) 1615-1625
23. Neuman M.G., Malkiewicz I.M., and Shear N.H. A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes. Clinical Biochemistry 33 (2000) 517-524
24. Pedersen P.L., Grenawalt J.W., Reynafarje B., Hullihen J., Decker G.L., Soper J.W., and Bustamente E. Preparation and characterization of mitochondria and submitochondrial particles of rat liver-derived tissues. Methods in Cell Biology 20 (1978) 411-481
25. Pessayre D., Mansouri A., Haouzi D., and Fromenty B. Hepatotoxicity due to mitochondrial dysfunction. Cell Biology and Toxicology. 15 (1999) 367-373
26. Santos A.C., Uyemura S.A., Santos N.A., Mingatto F.E., and Curti C. Hg(II)-induced renal cytotoxicity: in vitro and in vivo implications for the bioenergetic and oxidative status of mitochondria. Molecular and Cellular Biochemistry 177 (1997) 53-59
27. Scarpa A. Measurements of cation transport with metallochromic indicators. Methods Enzymology 56 (1979) 301-338
28. Shear N.H., and Spielberg S.P. Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. The Journal of Clinical Investigation 82 (1988) 1826-1832
29. Sierra N.M., Garcia B., Marco J., Plaza S., Hidalgo F., and Bermejo T. Cross hypersensitivity syndrome between phenytoin and carbamazepine. Pharmacy World & Science 27 (2005) 170-174
30. Spielberg S.P., Gordon G.B., Blake D.A., Mellits E.D., and Bross D.S. Anticonvulsant toxicity in vitro: possible role of arene oxides. The Journal of Pharmacology and Experimental Therapeutics 217 (1981) 386-389
31. Tong V., Teng X.W., Chang T.K., and Abbott F.S. Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes. Toxicological Sciences 86 (2005) 436-443
32. Zaccara G., Franciotta D., and Perucca E. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia. 48 (2007) 1223-1244
33. Zwanzger P., Eser D., and Rupprecht R. Anticonvulsants in the treatment of anxiety - an alternative treatment option?. Nervenarzt 78 (2007) 1274-1282