Ameliorative effects of taurine against methimazole-induced cytotoxicity in isolated rat hepatocytes

Scientia Pharmaceutica

Volumn 80, Issue 4, 2012, Pages 987-999

  Heidari, Reza ^a,b   Babaei, Hossein ^a,b   Eghbal, Mohammad Ali ^a,b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Hepatotoxicity; Methimazole; N methylthiourea; Taurine

Indexed keywords

DRUG METABOLITE; GLUTATHIONE; GLUTATHIONE DISULFIDE; METHYLTHIOUREA; REACTIVE OXYGEN METABOLITE; TAURINE; THIAMAZOLE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; LIPID PEROXIDATION; LIVER CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; RAT;

EID: 84870923627     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.1205-16     Document Type: Article

References (28)

1. Cooper DS. Antithyroid Drugs. N Engl J Med. 2005; 352: 905-917. http://dx.doi.org/10.1056/NEJMra042972
2. Gallelli L, Staltari O, Palleria C, De Sarro G, Ferraro M. Hepatotoxicity Induced by Methimazole in a Previously Health Patient. Curr Drug Safety. 2009; 4: 204-206. http://dx.doi.org/10.2174/157488609789006912
3. Livadas S, Xyrafis X, Economou F, Boutzios G, Christou M, Zerva A, Karachalios A, Palioura H, Palimeri S, Diamanti-Kandarakis E. Liver failure due to antithyroid drugs: report of a case and literature review. Endocrine. 2010; 38: 24-28. http://dx.doi.org/10.1007/s12020-010-9348-y
4. Mizutani T, Yoshida K, Murakami M, Shirai M, Kawazoe S. Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies. Chem Res Toxicol. 2000; 13: 170-176. http://dx.doi.org/10.1021/tx990155o
5. Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992; 72: 101-163. http://www.ncbi.nlm.nih.gov/pubmed/1731369
6. Das J, Ghosh J, Manna P, Sil PC. Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res. 2010; 44: 340-355. http://dx.doi.org/10.3109/10715760903513017
7. Manna P, Sinha M, Sil P. Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction. Amino Acids. 2009; 36: 417-428. http://dx.doi.org/10.1007/s00726-008-0094-x
8. Fang Y-J, Chiu C-H, Chang Y-Y, Chou C-H, Lin H-W, Chen M-F, Chen Y-C. Taurine ameliorates alcoholic steatohepatitis via enhancing self-antioxidant capacity and alcohol metabolism. Food Res Int. 2011; 44: 3105-3110. http://dx.doi.org/10.1016/j.foodres.2011.08.004
9. Kerai MD, Waterfield CJ, Kenyon SH, Asker DS, Timbrell JA. Taurine: protective properties against ethanol-induced hepatic steatosis and lipid peroxidation during chronic ethanol consumption in rats. Amino Acids. 1998; 15: 53-76. http://dx.doi.org/10.1007/BF01345280
10. Sinha M, Manna P, Sil PC. Taurine, a conditionally essential amino acid, ameliorates arsenic-induced cytotoxicity in murine hepatocytes. Toxicol In Vitro. 2007; 21: 1419-1428. http://dx.doi.org/10.1016/j.tiv.2007.05.010
11. Waters E, Wang J H, Redmond HP, Wu QD, Kay E, Bouchier-Hayes D. Role of Taurine in Preventing Acetaminophen-Induced Hepatic Injury in the Rat. Am J Physiol Gastrointest Liver Physiol. 2001; 280: G1274-G1279. http://www.ncbi.nlm.nih.gov/pubmed/11352821
12. Schaffer SW, Azuma J, Mozaffari M. Role of antioxidant activity of taurine in diabetes. Can J Physiol Pharmacol. 2009; 87: 91-99. http://dx.doi.org/10.1139/Y08-110
13. Mas MR, Isik AT, Yamanel L, Inal V, Tasci I, Deveci S, Mas N, Comert B, Akay C. Antioxidant treatment with taurine ameliorates chronic pancreatitis in an experimental rat model. Pancreas. 2006; 33: 77-81. http://dx.doi.org/10.1097/01.mpa.0000222316.74607.07
14. Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biochem J. 1988; 256: 251-255. http://www.ncbi.nlm.nih.gov/pubmed/2851980
15. Wu QD, Wang JH, Fennessy F, Redmond HP, Bouchier-Hayes D. Taurine prevents high-glucose-induced human vascular endothelial cell apoptosis. Am J Physiol. 1999; 277: C1229-C1238. http://www.ncbi.nlm.nih.gov/pubmed/10600775
16. Mizutani T, Yoshida K, Murakami M, Shirai M, Kawazoe S. Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies. Chem Res Toxicol. 2000; 13: 170-176. http://dx.doi.org/10.1021/tx990155o
17. Mansuy D, Dansette PM. Sulfenic acids as reactive intermediates in xenobiotic metabolism. Arch Biochem Biophys. 2011; 507: 174-185. http://dx.doi.org/10.1016/j.abb.2010.09.015
18. Benzie IFF. Lipid peroxidation: a review of causes, consequences, measurement and dietary influences. Int J Foos Sci Nutr. 1996; 47: 233-261. http://dx.doi.org/10.3109/09637489609012586
19. Forman HJ, Zhang H, Rinna A. Glutathione: Overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009; 30: 1-12. http://dx.doi.org/10.1016/j.mam.2008.08.006
20. Kowaltowski AJ, Vercesi AE. Mitochondrial damage induced by conditions of oxidative stress. Free Radic Biol Med. 1999; 26: 463-471. http://dx.doi.org/10.1016/S0891-5849(98)00216-0
21. Eghbal MA, Pennefather PS, O'Brien PJ. H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation. Toxicology. 2004; 203: 69-76. http://dx.doi.org/10.1016/j.tox.2004.05.020
22. Niknahad H, O'Brien PJ. Mechanism of sulfite cytotoxicity in isolated rat hepatocytes. Chem Biol Interact. 2008; 174: 147-154. http://dx.doi.org/10.1016/j.cbi.2008.05.032
23. Juan G, Cavazzoni M, Saez GT, O'Connor JE. A fast kinetic method for assessing mitochondrial membrane potential in isolated hepatocytes with rhodamine 123 and flow cytometry. Cytometry. 1994; 15: 335-342. http://dx.doi.org/10.1002/cyto.990150409
24. Smith MT, Thor H, Hartizell P, Orrenius S. The measurement of lipid peroxidation in isolated hepatocytes. Biochem Pharmacol. 1982; 31: 19-26. http://dx.doi.org/10.1016/0006-2952(82)90230-1
25. Riener CK, Kada G, Gruber HJ. Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridine. Anal Bioanal Chem. 2002; 373: 266-276. http://dx.doi.org/10.1007/s00216-002-1347-2
26. Kleinman WA, Richie JP Jr. Status of glutathione and other thiols and disulfides in human plasma. Biochem Pharmacol. 2000; 60: 19-29. http://dx.doi.org/10.1016/S0006-2952(00)00293-8
27. Rahman I, Kode A, Biswas SK. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc. 2006; 1: 3159-3165. http://dx.doi.org/10.1038/nprot.2006.378
28. LeBel CP, Ischiropoulos H, Bondy SC. Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol. 1992; 5: 227-231. http://dx.doi.org/10.1021/tx00026a012