Screening milk-derived antihypertensive peptides using quantitative structure activity relationship (QSAR) modelling and invitro/invivo studies on their bioactivity

International Dairy Journal

Volumn 35, Issue 1, 2014, Pages 95-101

  Jing, Pu ^a   Qian, Bingjun ^a   He, Yawen ^a   Zhao, Xin ^a   Zhang, Jianhua ^a   Zhao, Daxian ^b   Lv, Yingfang ^a   Deng, Yun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACE ACTIVITIES; ACE-INHIBITORY ACTIVITY; ANGIOTENSIN I-CONVERTING ENZYME; ANTIHYPERTENSIVE PEPTIDES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP MODELING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS; SARCOPLASMIC RETICULUM; SYSTOLIC BLOOD PRESSURE(SBP);

COMPENSATION (PERSONNEL); COMPUTATIONAL CHEMISTRY; PROTEINS;

AMINO ACIDS;

EID: 84888400322     PISSN: 09586946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.idairyj.2013.10.009     Document Type: Article

References (38)

1. Abubakar A., Saito T., Kittazawa H., Kawai Y., Itoh T. Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. Journal of Dairy Science 1998, 81:3131-3138.
2. Asano K., Zisman L.S., Bristow M.R. Angiotensin II receptors in the normal and failing heart. Heart Failure Reviews 1999, 3:199-208.
3. Braga F.C., Serra C.P., Viana N.S.J., Oliveira A.B., Cortes S.F., Lombardi J.A. Angiotensin-converting enzyme inhibition by Brazilian plants. Fitoterapia 2007, 78:353-358.
4. Cheung H.S., Feng L.W., Ondetti M.A., Sabo E.F., Cushman D.W. Binding of peptide substrates and inhibitors of angiotensin-converting-enzyme. Journal of Biological Chemistry 1980, 255:401-407.
5. 2+ -ATPase gene in rat heart. Chinese Journal of Biochemistry and Molecular Biology 1999, 15:284-288.
6. Cushman D.W., Cheung H.S. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochemistry Pharmacology 1971, 20:1637-1648.
7. Fang H., Luo M., Sheng Y., Li Z.X., Wu Y.Q., Liu C. The antihypertensive effect of peptides: a novel alternative to drugs?. Peptides 2008, 29:1062-1071.
8. FitzGerald R.J., Murray B.A., Walsh D.J. Hypotensive peptides from milk proteins. Journal of Nutrition 2004, 134:980S-988S.
9. Fujita H., Yokoyama T., Yoshikawa M. Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. Journal of Food Science 2000, 65:564-569.
10. Gisbert S., Wieland S., Gerd W., Johannes M., Eberhard N., Wolfgang R., et al. Peptide design by artificial neural networks and computer-based evolutionary search. Proceedings of the National Academy Sciences. USA 1998, 95:12179-12184.
11. Hellberg S., Sjostrom M., Skagerberg B., Wold S. Peptide quantitative structure-activity relationships, a multivariate approach. Journal of Medicinal Chemistry 1987, 30:1126-1135.
12. Jarrett R.J., Keen H., McCartney M., Fuller J.H., Hamilton P.J., Reid D.D., et al. Glucose tolerance and blood pressure in two population samples: their relation to diabetes mellitus and hypertension. International Journal of Epidemiology 1978, 7:15-24.
13. Jawaid T., Maddheshiya P., Awasthi A. Hypertension and herbal plants. International Research Journal of Pharmacy 2011, 2:26-30.
14. Kajimoto O., Aihara K., Hirata H., Takahashi R., Nakamura Y. Hypotensive effects of the tablets containing "Lactotripeptides (VPP, IPP)". Journal of Nutritional Food 2001, 4:51-61.
15. Lin Z.H., Long H.X., Bo Z., Wang Y.Q., Wu Y.Z. New descriptors of amino acids and their application to peptide QSAR study. Peptides 2008, 29:1798-1805.
16. Maeno M., Yamamoto N., Takano T. Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. Journal of Dairy Science 1996, 79:1316-1321.
17. Martínez-Maqueda D., Miralles B., Recio I., Hernández-Ledesma B. Antihypertensive peptides from food proteins: a review. Food and Function 2012, 3:350-361.
18. McGrowder D., Ragoobirsingh D., Dasgupta T. The effect of captopril on blood glucose, plasma insulin and blood pressure via a nitric oxide-independent mechanism in an animal model. Diabetologia Croatica 2003, 32:125-131.
19. Meisel H., Walsh D.J., Murray B., FitzGerald R.J. ACE inhibiting peptides. Nutraceutical proteins and peptides in health and disease 2005, 269-315. CRC Press, New York, NY, USA. Y. Mine, F. Shahidi (Eds.).
20. Mizushima S., Ohshige K., Watanabe J., Kimura M., Kadowaki T., Nakamura Y., et al. Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men. American Journal of Hypertension 2004, 17:701-706.
21. Motoi H., Kodama T. Isolation and characterization of angiotensin I-converting enzyme inhibitory peptides from wheat gliadin hydrolysate. Nahrung/Food 2003, 47:354-358.
22. Murakami M., Tonouchi H., Takahashi R., Kitazawa H., Kawai Y., Negishi H., et al. Structural analysis of a new anti-hypertensive peptides (β-lactosin B) isolated from a commercial whey product. Journal of Dairy Science 2004, 87:1967-1974.
23. Murray B.A., Fitzgerald R.J. Angiotensin converting enzyme inhibitory peptides derived from food proteins: biochemistry bioactivity and production. Current Pharmaceutical Design 2007, 13:773-791.
24. Nagai T., Suzuki N., Nagashima T. Antioxidative activities and angiotensin I-converting enzyme inhibitory activities of enzymatic hydrolysates from commercial kamaboko type samples. Food Science and Technology 2006, 12:335-346.
25. Nakamura Y., Yamamoto N., Sakai K., Okubo A., Yamazaki S., Takano T. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. Journal of Dairy Science 1995, 78:777-783.
26. Nakamura Y., Yamamoto N., Sakai K., Takano T. Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme. Journal of Dairy Science 1995, 78:1253-1257.
27. Nakashima Y., Arihara K., Sasaki A., Mio H., Ishikawa S., Itoh M. Antihypertensive activities of peptides derived from porcine skeletal muscle myosin in spontaneously hypertensive rats. Journal of Food Science 2002, 67:434-437.
28. Nurminen M.L., Sipola M., Kaarto H., Pihlanto-Leppälä A., Piilola K., Korpela R., et al. α-Lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Life Sciences 2000, 66:1535-1543.
29. Robert W.P. Overview of the angiotensin-converting-enzyme inhibitors. American Journal of Health-system Pharmacy 2000, 57:S3-S7.
30. Seppo L., Jauhiainen T., Poussa T., Korpela R. Afermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. American Journal of Clinical Nutrition 2003, 77:26-330.
31. Skeggs L.T., Kahn J.E., Shumway N.P. The preparation and function of the angiotensin-converting enzyme. Journal of Experimental Medicine 1956, 103:295-299.
32. Takano T. Milk derived peptides and hypertension reduction. International Dairy Journal 1998, 8:375-381.
33. Tong J.B., Liu S.L., Zhou P., Wu B.L., Liang Z. Anovel descriptor of amino acids and its application in peptide QSAR. Journal of Theoretical Biology 2008, 253:90-97.
34. Tong X.Y., Evangelista A., Cohen R.A. Targeting the redox regulation of SERCA in vascular physiology and disease. Current Opinion in Pharmacology 2010, 10:133-138.
35. World health statistics 2012 2012, World Health Organization, WHO Press, Geneva, Switzerland.
36. Wu J., Ding X. Characterization of inhibition and stability of soy-protein-derived angiotensin I-converting enzyme inhibitory peptides. Food Research International 2002, 35:367-375.
37. Wu J.P., Aluko R.E., Nakai S. Structural requirements of angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides. Journal of Agricultural and Food Chemistry 2006, 54:732-738.
38. Zhang H., Liang W.Q., Yang X.J., Luo X., Jiang N., Ma H., et al. Carbon starved anther encodes a MYB domain protein that regulates sugar partitioning required for rice pollen development. Plant Cell 2010, 22:672-689.