Peptide design by artificial neural networks and computer-based evolutionary search

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 21, 1998, Pages 12179-12184

  Schneider, Gisbert ^a,f   Schrödl, Wieland ^b   Wallukat, Gerd ^c   Müller, Johannes ^d   Nissen, Eberhard ^c,d   Rönspeck, Wolfgang ^e   Wrede, Paul ^a   Kunze, Rudolf ^b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Imtox Inc   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^e Pepscan Immunoanalytik GmbH   (Germany)

^f F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Evolutionary design; Genetic algorithm; Peptide library; Screening; Adrenergic receptor

Indexed keywords

AMINO ACID SEQUENCE; ARTIFICIAL NEURAL NETWORK; COMPUTER ANALYSIS; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; EVOLUTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

EID: 0032514619     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.21.12179     Document Type: Article

References (33)

1. Mewes, H.-W., Doelz, R. & George, D. C. (1994) J. Biotechnol. 35, 239-256.
2. Cortese, R., ed. (1996) Combinatorial Libraries (de Gruyter, Berlin).
3. Katz, B. A. (1997) Annu. Rev. Biophys. Biomol. Struct. 26, 27-45.
4. Schneider, G., Grunert, H.-P., Schuchhardt, J., Wolf, K. U., Müller, G., Habermehl, K.-O., Zeichhardt, H. & Wrede, P. (1995) Min. Invas. Med. 6, 106-115.
5. Schneider, G., Schuchhardt, J. & Wrede, P. (1995) Biol. Cybern. 73, 245-254.
6. Schneider, G. & Wrede, P. (1994) Biophys. J. 66, 335-344.
7. Schneider, G., Schuchhardt, J. & Wrede, P. (1995) Biophys. J. 68, 434-447.
8. Limas, C. J., Goldenberg, I. F. & Limas, C. (1989) Circ. Res. 64, 97-103.
9. Magnusson, Y., Wallukat, G., Waagstein, F., Hjalmarson, Å. & Hoebke, J. (1994) Circulation 89, 2760-2767.
10. Cetta, F. & Michels, V. V. (1995) Ann. Med. 27, 169-173.
11. Wallukat, G. & Wollenberger, A. (1987) Biomed. Biochim. Acta 78, 634-639.
12. Wallukat, G., Wollenberger, A., Morwinski, R. & Pitschner, H.-F. (1995) J. Mol. Cell. Cardiol. 27, 397-406.
13. Gheysen, H. M., Moelen, R. H. & Barteling, S. J. (1984) Proc. Natl. Acad. Sci. USA 81, 3998-4002.
14. Gheysen, H. M., Rodda, S. J., Mason, T. J., Tribbik, G. & Schoofs, P. G. (1987) J. Immunol. Methods 102, 259-274.
15. Schneider, T., Hildebrand, W., Rönspeck, W., Weigelt, W. & Pauli, G. (1990) AIDS Res. Hum. Retroviruses 6, 943-949.
16. Vinga-Martins, C., Schneider, T., Werno, A., Rönspeck, W., Pauli, G. & Müller-Lansch, N. (1992) AIDS Res. Hum. Retroviruses 8, 1301-1309.
17. Merrifield, R. B. (1963) J. Am. Chem. Soc. 8, 2149-2154.
18. Atherton, E. & Sheppard, R. C. (1989) Solid Phase Peptide Synthesis, a Practical Approach (IRL, Oxford).
19. st European Peptide Symposium, eds. Giralt, E. & Andreu, D. (ESCOM, Leiden), pp. 67-68.
20. Wollenberger, A. & Wallukat, G. (1983) Biomed. Biochim. Acta 42, 917-929.
21. Halle, W. & Wollenberger, A. (1970) Am. J. Cardiol. 25, 292-299.
22. Kernighan, B. W. & Ritchie, D. M. (1988) The C Programming Language (Prentice-Hall, Englewood Cliffs, NJ).
23. Engelman, D. A., Steitz, T. A. & Goldman, A. (1986) Annu. Rev. Biophys. Biophys. Chem. 15, 321-353.
24. Harpaz, Y., Gerstein, M. & Chothia, C. (1994) Structure 2, 641-649.
25. Eigen, M., McCaskill, J. S. & Schuster, P. (1988) J. Phys. Chem. 92, 6881-6891.
26. Jollife, I. T. (1986) Principal Component Analysis (Springer, New York).
27. Sammon, J. W., Jr. (1969) IEEE Trans. Comput. C-18, 401-409.
28. Bienfait, B. & Gasteiger, J. (1997) J. Mol. Graph. Model. 15, 203-215.
29. Schneider, G. & Wrede, P. (1998) Prog. Biophys. Mol. Biol. 70, 175-222.
30. Kramer, A., Keitel, T., Winkler, K., Stöcklein, W., Höhne, W. & Schneider-Mergener, J. (1997) Cell 91, 799-809.
31. Devillers, J., ed. (1996) Neural Networks in QSAR and Drug Design (Academic, San Diego).
32. Schneider, G. & Wrede, P. (1993) J. Mol. Evol. 36, 586-595.
33. Gnann, J. W., Jr., McCormick, J. B., Mitchell, S., Nelson, J. A. & Oldstone, M. B. (1987) Science 237, 1346-1349.