A novel descriptor of amino acids and its application in peptide QSAR

Journal of Theoretical Biology

Volumn 253, Issue 1, 2008, Pages 90-97

  Tong, Jianbo ^a   Liu, Shuling ^a   Zhou, Peng ^b   Wu, Bulan ^c   Li, Zhiliang ^d  

^a SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c WEST VIRGINIA UNIVERSITY   (United States)

^d Institute for Molecular Pharmacy   (China)

Author keywords

Partial least square (PLS); Peptide; Principal component analysis (PCA); Quantitative structure activity relationship (QSAR); VSW descriptors

Indexed keywords

ALANYLALANYLSERYLLYSYLALANYLLEUCYLARGINYLTHREONYLALANYLSERYL ARGINYLLEUCYLALANYLARGINYLSERYLLEUCYLLEUCYLTHREONINE; ALANYLLEUCYLLYSYLALANYLALANYLLEUCYLLEUCYLALANYLISOLEUCYLLEUCYLLYSYL ISOLEUCYLVALYLARGINYLVALYLISOLEUCYLLYSYLLYSINE; AMINO ACID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUTAMINYLLYSYLALANYLALANYLSERYLARGINYLLEUCYLLEUCYLARGINYLALANYLL EUCYLSERYLLYSYLLEUCYLLEUCYLGLUTAMYLALANYLPHENYLALANINE; GLUTAMINYLLYSYLALANYLLEUCYLALANYLLYSYLLEUCYLALANYLLYSYLLYSYLALANYLL EUCYLLYSYLALANYLLEUCYLALANYLLYSYLGLUTAMINE; GLUTAMYLLEUCYLALANYLLYSYLLYSYLALANYLLEUCYLARGINYLALANYLLEUCYLLY SYLLYSYLALANYLLEUCYLLYSYLSERYLALANYLLYSYLLYSINE; GLUTAMYLLEUCYLALANYLLYSYLLYSYLALANYLLEUCYLLYSYLALANYLLEUCYLLYSYLLYSYL ALANYLLEUCYLLYSYLSERYLALANYLARGINYLARGININE; GLUTAMYLSERYLLEUCYLLYSYLALANYLARGINYLSERYLLEUCYLLYSYLLYSYLSERYLL EUCYLLYSYLLEUCYLLYSYLLYSYLLEUCYLLEUCINE; GLUTAMYLSERYLLYSYLALANYLALANYLLYSYLALANYLALANYLLYSYLLYSYLALANYL ALANYLLYSYLALANYLLYSYLALANYLSERYLGLUTAMIC ACID; GLUTAMYLTHREONYLGLUTAMYLLEUCYLALANYLLYSYLLYSYLALANYLLEUCYLLYSYL ALANYLLEUCYLLYSYLLEUCYLLYSYLLYSYLLEUCYLALANINE; GLUTAMYLTHREONYLPHENYLALANYLALANYLLYSYLLYSYLALANYLLEUCYLLYSYLALANYLL EUCYLGLUTAMYLLYSYLLEUCYLLEUCYLLYSYLLYSYLGLYCINE; LEUCYLLEUCYLALANYLISOLEUCYLLEUCYLLEUCYLLEUCYLALANYLLEUCYLLEUCYL ALANYLLEUCYLARGINYLLYSYLLYSYLVALYLLEUCYLALANINE; PHENYLALANYLALANYLSERYLLEUCYLLEUCYLGLYCYLLYSYLLEUCYLALANYLLYSYLLYSYLL EUCYLALANYLLYSYLLYSYLALANYLLEUCYLLYSINE; POLYPEPTIDE ANTIBIOTIC AGENT;

AMINO ACID; COMPARATIVE STUDY; ENZYME ACTIVITY; INHIBITOR; PEPTIDE; PRINCIPAL COMPONENT ANALYSIS; STATISTICAL ANALYSIS; THREE-DIMENSIONAL MODELING; TWO-DIMENSIONAL MODELING;

ARTICLE; CORRELATION COEFFICIENT; EXTERNAL VALIDITY; OVULATION PREDICTION; PARTIAL LEAST SQUARES REGRESSION; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL MODEL; VALIDATION PROCESS;

AMINO ACIDS; LEAST-SQUARES ANALYSIS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDE LIBRARY; PEPTIDES; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44749093539     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2008.02.030     Document Type: Article

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