Metabolomics reveals that carnitine palmitoyltransferase-1 is a novel target for oxidative inactivation in human cells

Genes to Cells

Volumn 18, Issue 12, 2013, Pages 1107-1119

  Setoyama, Daiki ^a   Fujimura, Yoshinori ^a   Miura, Daisuke ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; HYDROGEN PEROXIDE; LONG CHAIN FATTY ACID; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL METABOLISM; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; FATTY ACID OXIDATION; HELA CELL; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; SENESCENCE;

CARNITINE O-PALMITOYLTRANSFERASE; CELLS, CULTURED; HUMANS; HYDROGEN PEROXIDE; METABOLOMICS; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84888377791     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/gtc.12098     Document Type: Article

References (49)

1. 2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J. Clin. Invest. 119, 573-581.
2. Bachi, A., Dalle-Donne, I. & Scaloni, A. (2013) Redox proteomics: chemical principles, methodological approaches and biological/biomedical promises. Chem. Rev. 113, 596-698.
3. Balaban, R.S., Nemoto, S. & Finkel, T. (2005) Mitochondria, oxidants, and aging. Cell 120, 483-495.
4. Beckman, K.B. & Ames, B.N. (1998) The free radical theory of aging matures. Physiol. Rev. 78, 547-581.
5. Beinert, H. & Kiley, P.J. (1999) Fe-S proteins in sensing and regulatory functions. Curr. Opin. Chem. Biol. 3, 152-157.
6. Berlett, B.S. & Stadtman, E.R. (1997) Protein oxidation in aging, disease, and oxidative stress. J. Biol. Chem. 272, 20313-20316.
7. Bonnefont, J.-P., Djouadi, F., Prip-Buus, C., Gobin, S., Munnich, A. & Bastin, J. (2004) Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. Mol. Aspects Med. 25, 495-520.
8. Bret, H.G. (2013) Mitochondrial deficiency is associated with insulin resistance. Diabetes 62, 1032-1035.
9. Brodie, A.E. & Reed, D.J. (1987) Reversible oxidation of glyceraldehyde 3-phosphate dehydrogenase thiols in hdman lung carcinoma cells by hydrogen peroxide. Blochem. Biophys. Res. Commun. 148, 120-125.
10. Brown, N.E., Anderson, R.C., Caplann, S.L., Foster, D.W. & Ii, J.D.M. (1994) Catalytically important domains of rat carnitine palmitoyltransferase I1 as determined by site-directed mutagenesis and chemical modification. J. Biol. Chem. 269, 19157-19162.
11. Bylesjö, M., Rantalainen, M., Cloarec, O., Nicholson, J.K., Holmes, E. & Trygg, J. (2007) OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification y. J. Chemometr. 20, 341-351.
12. Cocco, T., Di Paola, M., Papa, S. & Lorusso, M. (1999) Arachidonic acid interaction with the mitochondrial electron transport chain promotes reactive oxygen species generation. Free Radical Biol. Med. 27, 51-59.
13. Constantinides, P.P. & Steim, J.M. (1986) Solubility of palmitoyl-coenzyme A in acyltransferase. Arch. Biochem. Biophys. 250, 267-270.
14. Cotto-Rios, X.M., Békés, M., Chapman, J., Ueberheide, B. & Huang, T.T. (2012) Deubiquitinases as a signaling target of oxidative stress. Cell Rep. 2, 1475-1484.
15. Cumming, R.C., Andon, N.L., Haynes, P.A., Park, M., Fischer, W.H. & Schubert, D. (2004) Protein disulfide bond formation in the cytoplasm during oxidative stress. J. Biol. Chem. 279, 21749-21758.
16. D'Autréaux, B. & Toledano, M.B. (2007) ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat. Rev. Mol. Cell Biol. 8, 813-824.
17. Dettmer, K., Aronov, P.A. & Hammock, B.D. (2007) Mass spectrometry-based metabolomics. Mass Spectrom. Rev. 26, 51-78.
18. Dobbins, R.L., Szczepaniak, L.S., Bentley, B., Esser, V., Myhill, J. & Mcgarry, J.D. (2001) Prolonged inhibition of muscle carnitine lipid accumulation and insulin resistance in rats. Diabetes 50, 123-130.
19. Fiehn, O. (2002) Metabolomics-the link between genotypes and phenotypes. Plant Mol. Biol. 48, 155-171.
20. Finkel, T. (2003) Oxidant signals and oxidative stress. Curr. Opin. Cell Biol. 15, 247-254.
21. Finkel, T. & Holbrook, N.J. (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-247.
22. Franco, R., Schoneveld, O., Georgakilas, A.G. & Panayiotidis, M.I. (2008) Oxidative stress, DNA methylation and carcinogenesis. Cancer Lett. 266, 6-11.
23. Ghezzi, P. & Bonetto, V. (2003) Redox proteomics: identification of oxidatively modified proteins. Proteomics 3, 1145-1153.
24. Giorgio, M., Trinei, M., Migliaccio, E. & Pelicci, P.G. (2007) Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat. Rev. Mol. Cell Biol. 8, 722-728.
25. Gómez, L.A., Heath, S.-H.D. & Hagen, T.M. (2012) Acetyl-l-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the l-carnitine content in the rat heart. Mech. Ageing Dev. 133, 99-106.
26. Goossens, V., Grooten, J., De Vos, K. & Fiers, W. (1995) Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc. Natl Acad. Sci. USA 92, 8115-8119.
27. Hwang, N.R., Yim, S.-H., Kim, Y.M., Jeong, J., Song, E.J., Lee, Y., Lee, J.H., Choi, S. & Lee, K.-J. (2009) Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions. Biochem. J. 423, 253-264.
28. Junker, B.H., Klukas, C. & Schreiber, F. (2006) VANTED: a system for advanced data analysis and visualization in the context of biological networks. BMC Bioinformatics 7, 109.
29. Jurkowska, R.Z., Jurkowski, T.P. & Jeltsch, A. (2011) Structure and function of mammalian DNA methyltransferases. Chembiochem 12, 206-222.
30. Kim, J.Y., Kim, D.H., Choi, J., Park, J.-K., Jeong, K.-S., Leeuwenburgh, C., Yu, B.P. & Chung, H.Y. (2009) Changes in lipid distribution during aging and its modulation by calorie restriction. Age (Dordr) 31, 127-142.
31. Koves, T.R., Ussher, J.R., Noland, R.C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J.R.B., Newgard, C.B., Lopaschuk, G.D. & Muoio, D.M. (2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7, 45-56.
32. Lanza, I.R. & Nair, K.S. (2009) Functional assessment of isolated mitochondria in vitro. Methods Enzymol. 457, 349-372.
33. Lee, H., Choi, C.S., Birkenfeld, A.L. et al. (2010) Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab. 12, 668-674.
34. 2 by metal-catalysed histidine oxidation. Nature 440, 363-367.
35. Madsen, R., Lundstedt, T. & Trygg, J. (2010) Chemometrics in metabolomics-a review in human disease diagnosis. Anal. Chim. Acta 659, 23-33.
36. McGarry, J.D. & Brown, N.F. (1997) The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244, 1-14.
37. Meng, T.-C., Fukada, T. & Tonks, N.K. (2002) Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol. Cell 9, 387-399.
38. Ostman, A., Frijhoff, J., Sandin, A. & Böhmer, F.-D. (2011) Regulation of protein tyrosine phosphatases by reversible oxidation. J. Biochem. 150, 345-356.
39. Patti, G.J. (2011) Separation strategies for untargeted metabolomics. J. Sep. Sci. 34, 3460-3469.
40. Patti, G.J., Yanes, O. & Siuzdak, G. (2012) Innovation: metabolomics: the apogee of the omics trilogy. Nat. Rev. Mol. Cell Biol. 13, 263-269.
41. Purevsuren, J., Kobayashi, H., Hasegawa, Y., Yamada, K., Takahashi, T., Takayanagi, M., Fukao, T., Fukuda, S. & Yamaguchi, S. (2013) Intracellular in vitro probe acylcarnitine assay for identifying deficiencies of carnitine transporter and carnitine palmitoyltransferase-1. Anal. Bioanal. Chem. 405, 1345-1351.
42. Sohal, R.S. & Orr, W.C. (2012) The redox stress hypothesis of aging. Free Radical Biol. Med. 52, 539-555.
43. Tretter, L. & Adam-Vizi, V. (2000) Inhibition of Krebs cycle enzymes by hydrogen peroxide: a key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. J. Neurosci. 20, 8972-8979.
44. Turrens, J.F. & Boveris, A. (1980) Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem. J. 191, 421-427.
45. 2. J. Biol. Chem. 269, 2405-2410.
46. Wiklund, S., Johansson, E., Sjöström, L., Mellerowicz, E.J., Edlund, U., Shockcor, J.P., Gottfries, J., Moritz, T. & Trygg, J. (2008) Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal. Chem. 80, 115-122.
47. Yan, L.J., Levine, R.L. & Sohal, R.S. (1997) Oxidative damage during aging targets mitochondrial aconitase. Proc. Natl Acad. Sci. USA 94, 11168-11172.
48. Ying, W. (2008) NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid. Redox Signal. 10, 179-206.
49. Zawia, N.H., Lahiri, D.K. & Cardozo-pelaez, F. (2009) Epigenetics, oxidative stress, and Alzheimer disease. Free Radical Biol. Med. 46, 1241-1249.