TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 48, 2013, Pages 19531-19536

  Gonçalves, Lígia Antunes ^a   Rodrigues Duarte, Lurdes ^a   Rodo, Joana ^a   De Moraes, Luciana Vieira ^a   Marques, Isabel ^a   Penha Gonçalves, Carlos ^a  

^a INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CD68 ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE RECEPTOR; MESSENGER RNA; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; BACKCROSSING; BELR1 GENE; BRAIN MALARIA; CELL ACTIVATION; CHROMOSOME 17; CHROMOSOME 6; CONTROLLED STUDY; FEMALE; GENE; GENE CLUSTER; GENE EXPRESSION; GENETIC RESISTANCE; GENOTYPE; HEPATITIS; HEREDITY; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; KUPFFER CELL; LIVER CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MALARIA; MALE; MOUSE; NONHUMAN; PARASITE LOAD; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPOROZOITE; UPREGULATION;

ANIMALS; DNA PRIMERS; FLOW CYTOMETRY; GENETIC LOCI; GENOTYPE; IMMUNITY, INNATE; KUPFFER CELLS; LIVER; MALARIA; MEMBRANE GLYCOPROTEINS; MICE; MICROSATELLITE REPEATS; PLASMODIUM BERGHEI; RECEPTORS, IMMUNOLOGIC; STATISTICS, NONPARAMETRIC;

EID: 84888369228     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1306873110     Document Type: Article

References (39)

1. Borrmann S, Matuschewski K (2011) Targeting Plasmodium liver stages: Better late than never. Trends Mol Med 17(9): 527-536.
2. Lindner SE, Miller JL, Kappe SH (2012) Malaria parasite pre-erythrocytic infection: Preparation meets opportunity. Cell Microbiol 14(3): 316-324.
3. Derbyshire ER, Prudêncio M, Mota MM, Clardy J (2012) Liver-stage malaria parasites vulnerable to diverse chemical scaffolds. Proc Natl Acad Sci USA 109(22): 8511-8516.
4. Vaughan AM, Kappe SH (2013) Vaccination using radiation- or genetically attenuated live sporozoites. Methods Mol Biol 923: 549-566.
5. Prudêncio M, Rodriguez A, Mota MM (2006) The silent path to thousands of merozoites: The Plasmodium liver stage. Nat Rev Microbiol 4(11): 849-856.
6. Silvie O, et al. (2003) Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. Nat Med 9(1): 93-96.
7. Rodrigues CD, et al. (2008) Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection. Cell Host Microbe 4(3): 271-282.
8. Yalaoui S, et al. (2008) Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection. Cell Host Microbe 4(3): 283-292.
9. Pradel G, Frevert U (2001) Malaria sporozoites actively enter and pass through rat Kupffer cells prior to hepatocyte invasion. Hepatology 33(5): 1154-1165.
10. Mota MM, et al. (2001) Migration of Plasmodium sporozoites through cells before infection. Science 291(5501): 141-144.
11. Torgler R, et al. (2008) Sporozoite-mediated hepatocyte wounding limits Plasmodium parasite development via MyD88-mediated NF-kappa B activation and inducible NO synthase expression. J Immunol 180(6): 3990-3999.
12. Klotz C, Frevert U (2008) Plasmodium yoelii sporozoites modulate cytokine profile and induce apoptosis in murine Kupffer cells. Int J Parasitol 38(14): 1639-1650.
13. Liehl P, Mota MM (2012) Innate recognition of malarial parasites by mammalian hosts. Int J Parasitol 42(6): 557-566.
14. Epiphanio S, et al. (2008) Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection. Cell Host Microbe 3(5): 331-338.
15. Khan ZM, Ng C, Vanderberg JP (1992) Early hepatic stages of Plasmodium berghei: Release of circumsporozoite protein and host cellular inflammatory response. Infect Immun 60(1): 264-270.
16. van de Sand C, et al. (2005) The liver stage of Plasmodium berghei inhibits host cell apoptosis. Mol Microbiol 58(3): 731-742.
17. Khan ZM, Vanderberg JP (1991) Role of host cellular response in differential susceptibility of nonimmunized BALB/c mice to Plasmodium berghei and Plasmodium yoelii sporozoites. Infect Immun 59(8): 2529-2534.
18. Scheller LF, Wirtz RA, Azad AF (1994) Susceptibility of different strains of mice to hepatic infection with Plasmodium berghei. Infect Immun 62(11): 4844-4847.
19. Gonçalves LA, Almeida P, Mota MM, Penha-Gonçalves C (2008) Malaria liver stage susceptibility locus identified on mouse chromosome 17 by congenic mapping. PLoS ONE 3(3):e1874.
20. Allcock RJ, Barrow AD, Forbes S, Beck S, Trowsdale J (2003) The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol 33(2): 567-577.
21. Ford JW, McVicar DW (2009) TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 21(1): 38-46.
22. Sica A, Mantovani A (2012) Macrophage plasticity and polarization: In vivo veritas. J Clin Invest 122(3): 787-795.
23. Ejigiri I, et al. (2012) Shedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivity. PLoS Pathog 8(7):e1002725.
24. Heussler V, Rennenberg A, Stanway R (2010) Host cell death induced by the egress of intracellular Plasmodium parasites. Apoptosis 15(3): 376-385.
25. Vreden SG (1994) The role of Kupffer cells in the clearance of malaria sporozoites from the circulation. Parasitol Today 10(8): 304-308.
26. Sharif O, Knapp S (2008) From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunobiology 213(9-10): 701-713.
27. Sun M, et al. (2013) TREM-2 promotes host resistance against Pseudomonas aeruginosa infection by suppressing corneal inflammation via a PI3K/Akt signaling pathway. Invest Ophthalmol Vis Sci 54(5): 3451-3462.
28. Chen Q, et al. (2013) Triggering receptor expressed on myeloid cells-2 protects against polymicrobial sepsis by enhancing bacterial clearance. Am J Respir Crit Care Med 188(2): 201-212.
29. Sieber MW, et al. (2013) Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke. PLoS ONE 8(1): e52982.
30. Daws MR, et al. (2003) Pattern recognition by TREM-2: binding of anionic ligands. J Immunol 171(2): 594-599.
31. Correale C, et al. (2013) Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response. Gastroenterology 144(2): 346-356, e3.
32. N'Diaye EN, et al. (2009) TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol 184(2): 215-223.
33. Chimma P, et al. (2009) A distinct peripheral blood monocyte phenotype is associated with parasite inhibitory activity in acute uncomplicated Plasmodium falciparum malaria. PLoS Pathog 5(10):e1000631.
34. Erdman LK, et al. (2011) Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: A retrospective case-control study. PLoS ONE 6(2):e17440.
35. Turnbull IR, et al. (2006) Cutting edge: TREM-2 attenuates macrophage activation. J Immunol 177(6): 3520-3524.
36. Markel P, et al. (1997) Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet 17(3): 280-284.
37. Franke-Fayard B, et al. (2004) A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle. Mol Biochem Parasitol 137(1): 23-33.
38. Gonçalves LA, Vigário AM, Penha-Gonçalves C (2007) Improved isolation of murine hepatocytes for in vitro malaria liver stage studies. Malar J 6:169.
39. Goossens PL, Jouin H, Marchal G, Milon G (1990) Isolation and flow cytometric analysis of the free lymphomyeloid cells present in murine liver. J Immunol Methods 132(1): 137-144.