Ligand- and drug-binding studies of membrane proteins revealed through circular dichroism spectroscopy

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 1 PARTA, 2014, Pages 34-42

  Siligardi, Giuliano ^a,b   Hussain, Rohanah ^a   Patching, Simon G ^c   Phillips Jones, Mary K ^d  

^a DIAMOND LIGHT SOURCE LTD   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

Circular dichroism (CD) spectroscopy; kd determination; Ligand interactions; Membrane proteins; Synchrotron radiation circular dichroism (SRCD); Two component signal transduction

Indexed keywords

AROMATIC AMINO ACID; CARRIER PROTEIN; MEMBRANE PROTEIN; PHOSPHOLIPASE A2; SUGE PROTEIN; UNCLASSIFIED DRUG;

ACCURACY; AMINO ACID SEQUENCE; CIRCULAR DICHROISM; DRUG BINDING; HUMAN; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN LIGAND INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; QUANTITATIVE ANALYSIS; REVIEW; SIGNAL TRANSDUCTION; SYNCHROTRON RADIATION; ULTRAVIOLET RADIATION;

1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE; CD; CIRCULAR DICHROISM; CIRCULAR DICHROISM (CD) SPECTROSCOPY; DDM; DISSOCIATION CONSTANT; DMPC; DPPE; GBAP; GELATINASE BIOSYNTHESIS-ACTIVATING PHEROMONE; K(D); K(D) DETERMINATION; LIGAND INTERACTIONS; MEMBRANE PROTEINS; N-DODECYL-Β-D-MALTOSIDE; SRCD; SYNCHROTRON RADIATION CIRCULAR DICHROISM; SYNCHROTRON RADIATION CIRCULAR DICHROISM (SRCD); TM; TRANSMEMBRANE DOMAIN; TWO-COMPONENT SIGNAL TRANSDUCTION; ULTRAVIOLET; UV;

CIRCULAR DICHROISM; LIGANDS; MEMBRANE PROTEINS; OSMOLAR CONCENTRATION; PHARMACEUTICAL PREPARATIONS;

EID: 84888368393     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.06.019     Document Type: Review

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